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      Encefalitis de San Luis, descripción de un caso clínico.: Primera comunicación nacional

      case-report

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Resumen Se presenta un varón de 10 años procedente de una zona pobre de Montevideo, que ingresa a fines del verano por un cuadro de 6 días de evolución caracterizado al inicio por fiebre agregando, posteriormente, cefaleas muy intensas y elementos de irritación meníngea. En la evolución: confuso, fotofobia, incapacidad de responder órdenes simples, no reconoce a los familiares ni al personal. Hipertensión arterial. Luego de 6 días de evolución mejora espontáneamente. En la paraclínica el único elemento positivo en sangre fue IgM positiva para encefalitis de San Luis. Esta enfermedad es transmitida por picadura de mosquitos del género Culex. El virus pertenece a la familia Flaviviridae. No hay descripciones previas de esta enfermedad en el país.

          Translated abstract

          Summary A ten year old child with 6 days of fever who later added severe headache and meningeal irritation signs is presented. He proceeded from a poor area of Montevideo, and was admitted at hospital in late summer. During the evolution he added: mental confusion, photophobia, inability to recognize parents or medical staff, obey simple commands, and arterial hypertension. 6 days after he spontaneously improved. IgM for St. Louis encephalitis in blood test was the only positive discovery. St. Louis encephalitis is transmitted by Culex genus mosquitoes. The virus belongs to the Flaviviridae family. No previous description of this disease was founded in the country

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          Most cited references30

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          Epidemiology of St. Louis encephalitis virus.

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            St. Louis encephalitis vírus: first isolation from a human in São Paulo state, Brasil

            This paper reports the isolation of St. Louis encephalitis virus (SLEV) from a febrile human case suspected to be dengue, in São Pedro, São Paulo State. A MAC-ELISA done on the patient's acute and convalescent sera was inconclusive and hemagglutination inhibition test detected IgG antibody for flaviviruses. An indirect immunofluorescent assay done on the C6/36 cell culture inoculated with the acute serum was positive for flaviviruses but negative when tested with dengue monoclonal antibodies. RNA extracted from the infected cell culture supernatant was amplified by RT-PCR in the presence of NS5 universal flavivirus primers and directly sequenced. Results of BLAST search indicated that this sequence shares 93% nucleotide similarity with the sequence of SLEV (strain-MSI.7), confirmed by RT-PCR performed with SLEV specific primers. Since SLEV was identified as the cause of human disease, it is necessary to improve surveillance in order to achieve early detection of this agent in the state of São Paulo and in Brazil. This finding is also an alert to health professionals about the need for more complete clinical and epidemiological investigations of febrile illnesses as in the reported case. SLEV infections can be unrecognized or confused with other ones caused by an arbovirus, such as dengue.
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              Epidemiology of St: Louis encephalitis virus

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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                adp
                Archivos de Pediatría del Uruguay
                Arch. Pediatr. Urug.
                Sociedad Uruguaya de Pediatría (Montevideo )
                1688-1249
                December 2012
                : 83
                : 3
                : 181-184
                Affiliations
                [1 ] Asociación Española Primera de Socorros Mutuos
                [2 ] Asociación Española Primera de Socorros Mutuos
                Article
                S1688-12492012000300004
                39901b0b-9f52-421b-8d7c-88f4e4f6ef04

                http://creativecommons.org/licenses/by/4.0/

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                Product Information: website
                Self URI (journal page): http://www.scielo.edu.uy/scielo.php?script=sci_serial&pid=1688-1249&lng=en
                Categories
                ANESTHESIOLOGY
                MEDICAL ETHICS
                MEDICINE, GENERAL & INTERNAL
                MEDICINE, LEGAL
                PEDIATRICS
                SURGERY

                Social law,General medicine,Pediatrics,Surgery,Anesthesiology & Pain management,Internal medicine
                INSECT VECTORS,ENCEPHALITIS, ST. LOUIS,ENCEPHALITIS VIRUS, ST. LOUIS,CULEX,ENCEFALITIS DE SAN LUIS,VIRUS DE LA ENCEFALITIS DE SAN LUIS,INSECTOS VECTORES

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