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      Primary Glomeruionephritis with Predominant Mesangial Immunoglobulin G Deposits -A Distinct Entity?

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          Six cases of primary glomeruionephritis with predominant IgG deposits in the mesangium are described on the basis of a review of renal-biopsy-proven 1,116 cases with primary glomeruionephritis between 1977 and 1990. All patients were female (6-52 years old). Six patients appeared with microscopic hematuria: 3 with episodes of gross hematuria and 3 with mild proteinuria, but none with the nephrotic syndrome. Renal function was normal except for 1 case (52 years old) complicated with hypertension. Serum levels of immunoglobulins and complements were almost normal. Morphologically minor or focal/segmental glomerular alterations were observed. Immunofluorescence showed that pure mesangial IgG deposition was characterized in all cases, whereas no IgA nor IgM was found in any of them. Mesangial deposition of C3 and C1q was observed in 4 and 3 cases, respectively. Electron microscopy revealed dense deposits within the mesangial area in all cases. The clinical course was benign, and the complication with systemic diseases like a rheumatic disease was not observed. This primary glomeruionephritis is an entity characterized by low incidence in Japan, mild abnormalities in urinalysis, minor glomerular alterations with predominant mesangial IgG deposits and a relative benign course.

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          Author and article information

          S. Karger AG
          12 December 2008
          : 64
          : 1
          : 122-128
          aFourth Department of Medicine, Teikyo University School of Medicine, Kawasaki bDepartment of Medicine, Toshiba Rinkan Hospital, Sagamihara, cDepartment of Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan
          187291 Nephron 1993;64:122–128
          © 1993 S. Karger AG, Basel

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          Pages: 7
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