Effect of the novel antipsychotic drug perospirone on P-glycoprotein function and expression in Caco-2 cells.

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Abstract

Perospirone (PER) is a novel atypical antipsychotic drug for the treatment of schizophrenia and other psychotic disorders. The multidrug resistance transporter, P-glycoprotein (Pgp), is involved in the efflux transport of several antipsychotics across the blood-brain barrier (BBB). The aim of the present study was to evaluate the modulating effect of PER on both Pgp activity and expression in Caco-2 cell monolayers.

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Journal

Journal ID (iso-abbrev): Eur J Clin Pharmacol

Title: European journal of clinical pharmacology

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1432-1041

ISSN (Print): 0031-6970

Publication date (Electronic): Jul 2008

Volume: 64

Issue: 7

Affiliations

[1 ] The Clinical Pharmacy & Pharmacology Institute, XiangYa Second Hospital, Central South University, Changsha 410011, China.

Article

DOI: 10.1007/s00228-008-0487-5

PubMed ID: 18478216

SO-VID: 39b8c4a5-61cc-4830-8d6f-06706d026fab

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