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      Immunoglobulin A Nephropathy and Ulcerative Colitis

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          The immune response has largely been implicated in the pathogenesis of inflammatory bowel disease (ulcerative colitis and Crohn’s disease) and immunoglobulin A nephropathy. We present a 26-year-old woman with a long past history of asymptomatic macroscopic hematuria who later developed several episodes of bloody stools and abdominal pain. A colonic biopsy disclosed ulcerative colitis and a renal biopsy was consistent with immunoglobulin A nephropathy. Immunoglobulin A nephropathy is the most common glomerulonephritis, being end-stage renal disease a rare but the most serious complication. It can be primary or secondary, but the association between both entities is unusually observed. We discuss the possible immunologic mechanisms involved and believe the initial immunologic derangement originates in the bone marrow. We suggest both conditions must be considered when either a patient with ulcerative colitis and micro- or macrohematuria or with renal involvement and a past history of diarrhea or abdominal pain presents.

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          Chronic Interstitial Nephritis due to 5-Aminosalicylic Acid

          Nephrotoxicity has recently been reported with the use of 5-aminosalicylic acid (5-ASA) which has structural similarities to phenacetin and aspirin. The present paper describes 2 cases of interstitial nephritis and 1 case of end-stage failure associated with 5-ASA treatment. The first patient presented with severe renal failure which was partially reversed with 5-ASA discontinuation and steroid therapy. The second had severe renal failure (serum creatinine 469 mmol/l) but renal function stabilized with 5-ASA withdrawal. The third patient had end-stage renal failure and underwent hemodialysis and a successful kidney transplant.
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            IgA nephropathy: A stem cell disease?


              Author and article information

              Am J Nephrol
              American Journal of Nephrology
              S. Karger AG
              October 2001
              19 October 2001
              : 21
              : 5
              : 400-405
              aDivision of Nephrology, Department of Medicine; bDepartment of Pathology and cDivision of Gastroenterology, Department of Medicine, Hospital Británico de Buenos Aires, Argentina
              46283 Am J Nephrol 2001;21:400–405
              © 2001 S. Karger AG, Basel

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              Page count
              Figures: 3, References: 61, Pages: 6
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