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      Toxoplasmose em primatas neotropicais: estudo retrospectivo de sete casos Translated title: Toxoplasmosis in New World primates: Retrospective study of seven cases

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          Abstract

          A toxoplasmose é considerada uma doença parasitária fatal em primatas neotropicais. O objetivo deste trabalho foi descrever, através de um estudo retrospectivo, os casos de toxoplasmose em primatas neotropicais. No período de 1999-2009 foram realizados 86 exames anatomopatológicos em primatas e a toxoplasmose foi a enfermidade mais comum (7/86), relatando-se um caso em sagui-do-tufo-preto (Callithrix penicillata) e seis em bugio-ruivo (Alouatta guariba). Dois animais foram encontrados mortos e cinco morreram em poucos dias. Os sinais clínicos mais frequentes foram apatia e anorexia (5/7), distensão abdominal (4/7) e febre (3/7). Na necropsia observou-se esplenomegalia (4/7), hemorragia do trato digestório, linfonodos e bexiga (4/7), pulmões avermelhados (3/7) e hepatomegalia (2/7). No exame histopatológico evidenciou-se hepatite (7/7), esplenite (3/7), miocardite (2/7), enterite (2/7), linfadenite (1/7) e sialite (1/7) necróticas e, pneumonia intersticial (4/7). Em fígado, pulmões, baço, coração, linfonodos e glândula salivar havia taquizoítos de Toxoplasma gondii que foram também detectados pelo exame de imuno-histoquímica anti-T. gondii em fígado, baço e pulmões (5/7). A toxoplasmose pode causar alta mortalidade em colônias de primatas neotropicais e representar mais uma ameaça à conversação dessas espécies em cativeiro. Sendo assim, medidas preventivas devem ser tomadas para evitar a contaminação desses animais.

          Translated abstract

          Toxoplasmosis is considered to be a fatal parasitic disease in New World primates. The objective of this report was to describe, through a retrospective study, the toxoplasmosis cases in New World primates. From 1999 to 2009 eighty-six anatomopathological exams was performed in primates and toxoplasmosis was the most common disease (7/86). One case occurred in Black-Tufted-Marmoset (Callithrix penicillata) and six in Brown-Howler monkeys (Alouatta guariba). Two monkeys were found death and five died within few days. The most common clinical signs were apathy and anorexia (5/7), abdominal distension (4/7) and fever (3/7). The main gross lesions were splenomegaly (4/7), hemorrhage in digestory system, lymph nodes and urinary bladder (4/7), reddish lungs (3/7) and hepatomegaly (2/7). Histopathological findings were necrotizing hepatitis (7/7), splenitis (3/7), myocarditis (2/7), enteritis (2/7), lymphadenitis (1/7) and sialitis (1/7), and interstitial pneumonia (4/7). In the liver, lungs, spleen, heart, lymph nodes and salivary gland there were tachyzoites of Toxoplasma gondii that also detected by immunohistochemistry against T. gondii in liver, spleen and lungs (5/7). Toxoplasmosis can cause high mortality in New World primate colonies and can be a threat to preservation of those species in captivity. Therefore, preventive measures should be taken to avoid the contamination of those animals.

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          Most cited references23

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          Toxoplasmosis: comparative species susceptibility and host immune response.

          The protozoan parasite Toxoplasma gondii is capable of infecting all warm blooded animals; however, the consequences of infection are very variable between different species of animal. Marsupials and New World monkeys, which have evolved largely separately from the cat, the definitive host of the parasite, are among the most vulnerable species where infection with T. gondii can prove fatal. In more resistant species such as humans and sheep, infection is generally unapparent, provoking only mild symptoms; thereafter the host remains infected for life. However, when the immune system is compromised, such as in the immunologically immature fetus, infection with the parasite can have very serious consequences. Much of the work examining host immune responses has been done using experimentally infected mice. While there are many advantages in using this experimental model, care should be taken in extrapolating results from mice to other species. Mice are extremely vulnerable to the consequences of infection with T. gondii., and their use to further our understanding of congenital toxoplasmosis may not be ideal, as fetal infection can occur in successive pregnancies. This is not the case in rats or sheep; they are more resistant to the disease and therefore may provide a more relevant model for human congenital toxoplasmosis. Studies of host immune responses have emphasised the importance of the cytokine interferon gamma (IFN gamma) in resistance to T. gondii. The efficiency of induction of this cytokine may be critical for determining the outcome of the host-parasite relationship.
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            Diseases of the Callitrichidae: a review.

            S Potkay (1992)
            The Callitrichidae contains four genera that embrace up to 50 species and subspecies found in neotropical habitats. Certain members have either naturally occurring or induced conditions that serve as important models of human disease. They include viral, bacterial, and parasitic infections, nutritional deficiencies, neoplasia, and various other conditions. The spontaneous diseases of captive callitrichids and those to which these species are experimentally susceptible were reviewed.
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              Toxoplasmosis: a waterborne zoonosis

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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                pvb
                Pesquisa Veterinária Brasileira
                Pesq. Vet. Bras.
                Colégio Brasileiro de Patologia Animal - CBPA (Rio de Janeiro )
                1678-5150
                January 2013
                : 33
                : 1
                : 94-98
                Affiliations
                [1 ] Universidade do Estado de Santa Catarina Brazil
                [2 ] Universidade Federal de Mato Grosso Brazil
                [3 ] Universidade Regional de Blumenau Brazil
                Article
                S0100-736X2013000100017
                10.1590/S0100-736X2013000100017
                39e63ac8-f5bd-47fa-b1d1-003f19537563

                http://creativecommons.org/licenses/by/4.0/

                History
                Product

                SciELO Brazil

                Self URI (journal page): http://www.scielo.br/scielo.php?script=sci_serial&pid=0100-736X&lng=en
                Categories
                VETERINARY SCIENCES

                General veterinary medicine
                Toxoplasma gondii,toxoplasmosis,pathology,Neotropical primates,Santa Catarina,toxoplasmose,patologia,primatas neotropicais

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