This paper was developed after the participation of all authors in a workshop on the
topic, organised by the MRC PROGnosis RESearch Strategy (PROGRESS) Partnership (
www.progress-partnership.org), which is supported by a Medical Research Council Partnership Grant (G0902393) involving
University College London (HH, Aroon Hingorani, KIM), Oxford University (DGA), Birmingham
University (RDR), London School of Hygiene & Tropical Medicine (Ian Roberts, PP),
Keele University (PC, Daniëlle van der Windt), and Queen Mary University London (Adam
D Timmis). DGA is supported by a programme grant from Cancer Research UK (C5529).
HH is supported by grants from the UK National Institute for Health Research (RP-PG-0407-10314;
http://www.nihr.ac.uk/), and the Wellcome Trust (086091/Z/08/Z;
http://www.wellcome.ac.uk/) and by awards establishing the Farr Institute of Health Informatics Research at
UCLP Partners from the MRC, in partnership with Arthritis Research UK, the British
Heart Foundation, Cancer Research UK, the Economic and Social Research Council, the
Engineering and Physical Sciences Research Council, the National Institute of Health
Research, the National Institute for Social Care and Health Research (Welsh Assembly
Government), the Chief Scientist Office (Scottish Government Health Directorates)
and the Wellcome Trust (MR/K006584/1). EWS was partly funded by the NIH (NS-042691).
KGMM is supported by The Netherlands Organization for Scientific Research (ZON-MW
918.10.615 and 91208004). GP, PC, and Danielle van der Windt are supported by the
Arthritis Research UK Centre of Excellence in Primary Care. PC is a UK NIHR Senior
Investigator. The funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.