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      Δ9-Tetrahydrocannabinol produces naloxone-blockable enhancement of presynaptic basal dopamine efflux in nucleus accumbens of conscious, freely-moving rats as measured by intracerebral microdialysis

      , , , , ,

      Psychopharmacology

      Springer Nature

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          Most cited references 28

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          A psychomotor stimulant theory of addiction.

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            On the role of ascending catecholaminergic systems in intravenous self-administration of cocaine.

            The role of ascending noradrenergic (NA) and dopaminergic (DA) systems in intravenous self-administration of cocaine in rats was investigated by examining the effects of 6-hydroxydopamine-induced lesions of these systems on responding for the drug on a FR-1 schedule of reinforcement. Lesions of the dorsal and ventral NA bundles that reduced hippocampal-cortical NA by 96% and hypothalamic NA by 72% failed to have any effects on responding for cocaine. Lesions of the nucleus accumbens that reduced the DA content of this nucleus by 90% resulted in a significant and long-lasting (15 days) reduction in self-administration of cocaine. Apomorphine self-administration was not affected in the same animals. Identical lesions of the n accumbens had only transient (2-3 days) effects on food-reinforced operant responding, suggesting that the prolonged disruption of cocaine self-administration was not the result of motor deficits. The results are discussed with reference to the possibility that DA terminals in the n accumbens may mediate some of the positive reinforcing properties of cocaine.
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              Neuroleptics and operant behavior: The anhedonia hypothesis

               Roy Wise (1982)
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                Author and article information

                Journal
                Psychopharmacology
                Psychopharmacology
                Springer Nature
                0033-3158
                1432-2072
                October 1990
                October 1990
                : 102
                : 2
                : 156-162
                Article
                10.1007/BF02245916
                © 1990
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