Autoradiographic Localization of 1,25-Dihydroxyvitamin D 3  in Rat Placenta and Yolk Sac

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Abstract

After injection of 3H-1,25-(OH)-vitamin D3 into rats on days 18 and 20 of pregnancy, autoradiograms of placenta and fetal membranes show nuclear concentration of radioactivity in certain cells. This nuclear concentration is abolished when unlabeled 1,25-(OH)2-vitamin D3, but not 25-(OH)-vitamin D3, is injected prior to the labeled hormone. Nuclear labeling is observed in epithelial cells of visceral yolk sac and amnion, and in certain trophoblasts in basalis and labyrinth. The results suggest the presence of a specific receptorlike binding for 1,25-(OH)2-vitamin D3 and thus involvement of the target cells in calcium regulatory mechanisms during development.

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Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1983

Publication date (Print): 1983

Publication date (Electronic): 26 November 2008

Volume: 18

Issue: 4

Pages: 215-220

Affiliations

^aDepartment of Anatomy, University of North Carolina, Chapel Hill, N.C., USA; ^bDepartment of Anatomy, University of Ottawa, Ont., Canada; ^cDepartment of Biochemistry, University of Wisconsin, Madison, Wisc., USA

Article

Publisher ID: 179798 Other ID: Horm Res 1983;18:215–220

DOI: 10.1159/000179798

PubMed ID: 6688999

SO-VID: 3a277232-d377-4a36-ab94-d4529938d6ec

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 26 July 1982

Date accepted : 28 January 1983

Page count

Pages: 6

Autoradiographic Localization of 1,25-Dihydroxyvitamin D ₃ in Rat Placenta and Yolk Sac

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Karger: Endocrinology

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