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      Autoradiographic Localization of 1,25-Dihydroxyvitamin D 3 in Rat Placenta and Yolk Sac

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          After injection of <sup>3</sup>H-1,25-(OH)-vitamin D<sub>3</sub> into rats on days 18 and 20 of pregnancy, autoradiograms of placenta and fetal membranes show nuclear concentration of radioactivity in certain cells. This nuclear concentration is abolished when unlabeled 1,25-(OH)<sub>2</sub>-vitamin D<sub>3</sub>, but not 25-(OH)-vitamin D<sub>3</sub>, is injected prior to the labeled hormone. Nuclear labeling is observed in epithelial cells of visceral yolk sac and amnion, and in certain trophoblasts in basalis and labyrinth. The results suggest the presence of a specific receptorlike binding for 1,25-(OH)<sub>2</sub>-vitamin D<sub>3</sub> and thus involvement of the target cells in calcium regulatory mechanisms during development.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          26 November 2008
          : 18
          : 4
          : 215-220
          aDepartment of Anatomy, University of North Carolina, Chapel Hill, N.C., USA; bDepartment of Anatomy, University of Ottawa, Ont., Canada; cDepartment of Biochemistry, University of Wisconsin, Madison, Wisc., USA
          179798 Horm Res 1983;18:215–220
          © 1983 S. Karger AG, Basel

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