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      Effect of Pre-Enucleation Irradiation on the Survival of Patients with Uveal Melanoma

      ,

      Ophthalmologica

      S. Karger AG

      Enucleation, Irradiation, Pre-enucleation irradiation, Uveal melanoma

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          Abstract

          The effect of pre-enucleation irradiation on the survival of patients with uveal melanoma was investigated in 140 patients. Of the patients, 42 received pre-enucleation cobalt external radiotherapy 2,000 cGy, in five fractions between 1981–1991. The control group consisted of 98 patients with uveal melanoma treated by enucleation alone between 1964 and 1994. The great majority of tumors in each group were confined to the choroid. The mean follow-up period was 58.3 months in the irradiated group and 61.6 months in the enucleation group. A comparison of the Kaplan-Meier survival curves of the patients managed by pre-enucleation irradiation and enucleation indicated no significant difference in survival between the groups. After 5 years of follow-up, the survival rates for the preoperatively irradiated group and the control group were, 86.5 and 86.8%, respectively. In both groups, women had a significantly better survival than men. It is more likely that pre-enucleation irradiation does not appear to improve survival in patients with uveal melanoma. The reason for this may be the micrometastases that occur before treatment.

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          Author and article information

          Journal
          OPH
          Ophthalmologica
          10.1159/issn.0030-3755
          Ophthalmologica
          S. Karger AG
          0030-3755
          1423-0267
          1998
          August 1998
          18 June 1998
          : 212
          : 4
          : 231-235
          Affiliations
          Eye Clinic, Faculty of Medicine, University of Ankara, Turkey
          Article
          27298 Ophthalmologica 1998;212:231–235
          10.1159/000027298
          9672210
          © 1998 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Original Paper · Travail original · Originalarbeit

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