Bioanalysis of alectinib and metabolite M4 in human plasma, cross-validation and impact on PK assessment.

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Abstract

Alectinib is a novel anaplastic lymphoma kinase (ALK) inhibitor for treatment of patients with ALK-positive non-small-cell lung cancer who have progressed on or are intolerant to crizotinib. To support clinical development, concentrations of alectinib and metabolite M4 were determined in plasma from patients and healthy subjects.

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Journal

Journal ID (iso-abbrev): Bioanalysis

Title: Bioanalysis

Publisher: Future Science, LTD

ISSN (Electronic): 1757-6199

ISSN (Print): 1757-6180

Publication date (Electronic): Jul 2016

Volume: 8

Issue: 14

Affiliations

[1 ] Roche Pharmaceutical Research & Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland.

[2 ] Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd., 200 Kajiwara Kamakura Kanagawa, 247-8530 Japan.

[3 ] Roche Pharmaceutical Research & Early Development, Roche Innovation Center New York, F. Hoffmann-La Roche Ltd, 430 East 29th Street, New York, NY 10016, USA.

Article

DOI: 10.4155/bio-2016-0068

PubMed ID: 27329641

SO-VID: 3a55411f-323c-49bd-9d5c-8afffde10a86

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Keywords: anaplastic lymphoma kinase,column switching,cross-validation,matrix effect,non-small-cell lung cancer,phospholipids,plasma,Alecensa®,LC–MS/MS,alectinib

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Keywords: anaplastic lymphoma kinase, column switching, cross-validation, matrix effect, non-small-cell lung cancer, phospholipids, plasma, Alecensa®, LC–MS/MS, alectinib

Bioanalysis of alectinib and metabolite M4 in human plasma, cross-validation and impact on PK assessment.

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