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Abstract
Using gas chromatography/mass spectrometry we have developed a method for the simultaneous
determination of six plasma steroids: testosterone, 4-androstenedione, 17 alpha-hydroxyprogesterone,
5 alpha-androstane-3 alpha,17 beta-diol, 5 alpha-dihydrotestosterone, and dehydroepiandrosterone.
For each analyte, a deuterium-labeled internal standard was used for quantification.
Due to the high isotopic purity of our standards, no complex corrections for isotope
contributions were necessary. The procedure provides a sensitive and specific technique
with good accuracy and precision.