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Application of a translucent goggle over the chick eye on the first day after hatching
led to the development of myopia. By the 14th day, the mean refractive error was about
-10.0 D. Significant increases in axial and equatorial diameters were observed when
the treated eyes were compared with untreated contralateral eyes. The lens did not
appear to be affected, either optically or biochemically. A temporal study showed
that changes were evident within 2 days of goggle application, and were significantly
established 5 days later. Total soluble protein concentrations of the treated and
untreated eyes were not significantly different, nor were the dry weights of the sclera
and cornea. The enlargement of the eyeball that was observed in the experimental induction
of myopia seems due to an increase in fluid within the eye. The data are consistent
with the view that refractive properties of the chick eye are dependent upon the clarity
of the visual image and modulation of these features occurs after hatching.