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      Mitomycin C Influence on Inhibition of Cellular Proliferation and Subsequent Synthesis of Type I Collagen and Laminin in Primary and Recurrent Pterygia

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          Abstract

          The purpose was to investigate the biological effects of mitomycin C (MMC) on the inhibition of cellular proliferation and the subsequent synthesis of extracellular matrix like type I collagen (PIP) and laminin on primary and recurrent pterygia. The <sup>3</sup>H-thymidine assay for cellular proliferation was consistent with the MMC dose and time response of both pterygia. The cellular inhibitory effect of MMC was greater on recurrent pterygial cells than primary ones. The inhibition of laminin by MMC followed the dose and time-response curves, with a stronger effect found in recurrent pterygial cells, but no significant difference between the two types concerning type I collagen synthesis. The inhibition of fibroblast proliferation and subsequent synthesis of laminin by MMC was more marked in recurrent pterygium than the primary one.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          2001
          June 2001
          04 May 2001
          : 33
          : 3
          : 140-146
          Affiliations
          Department of Ophthalmology, Research Institute of Medical Science, College of Medicine, Pusan National University, Pusan City, Korea
          Article
          55660 Ophthalmic Res 2001;33:140–146
          10.1159/000055660
          11340404
          3a97c917-3652-4bdb-92b8-528a165d5495
          © 2001 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Page count
          Figures: 4, Tables: 3, References: 22, Pages: 7
          Categories
          Original Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Type I collagen (PIP),Mitomycin C,Laminin,Primary and recurrent pterygia

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