+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Differences in Norepinephrine Dynamics in Large and Small Pulmonary Arteries of Dog


      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          These studies address the apparent dissociation between the amounts of norepinephrine (NE) released from small and large pulmonary arteries of dogs by a standard electrical stimulus and the contractile tensions that developed in these tissues. Segments of vessels were studied in organ baths or in a superfusion apparatus during electrical stimulation. Endogenous NE was quantitated using liquid chromatography with electrochemical detection. ‘Release’ of NE was studied under conditions in which uptakes of NE from the synaptic cleft were impaired, and overflow of NE was studied when these uptakes were operative. ‘Release’ of NE was predictably greater than overflow in all arteries. In the large pulmonary artery, greater contractile tensions were measured when greater amounts of NE were present in superfusate. In the small pulmonary artery, contractile tensions did not directly correlate with the amounts of NE measured in the superfusate. These studies indicate that NE dynamics are different at neuroeffector junctions in large and small pulmonary arteries. Several explanations to account for these differences are discussed.

          Related collections

          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          23 September 2008
          : 25
          : 6
          : 265-272
          Departments of Anesthesiology, Physiology and Biophysics, Mayo Clinic and Mayo Foundation, Rochester, Minn., USA
          158740 Blood Vessels 1988;25:265–272
          © 1988 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Research Paper


          Comment on this article