18
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Human dignity and the creation of human–nonhuman chimeras

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          In this work I present a detailed critique of the dignity-related arguments that have been advanced against the creation of human–nonhuman chimeras that could possess human-like mental capacities. My main claim is that the arguments so far advanced are incapable of grounding a principled objection against the creation of such creatures. I conclude that these arguments have one, or more, of the following problems: (a) they confuse the ethical assessment of the creation of chimeras with the ethical assessment of how such creatures would be treated in specific contexts (e.g. in the laboratory), (b) they misrepresent how a being could be treated solely as means towards others’ ends, (c) they fall short of demonstrating how humanity’s dignity would be violated by the creation of such entities, and (d) they fail to properly characterise the moral responsibilities that moral agents have towards other moral agents and sentient beings.

          Related collections

          Most cited references44

          • Record: found
          • Abstract: found
          • Article: not found

          Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice.

          Human astrocytes are larger and more complex than those of infraprimate mammals, suggesting that their role in neural processing has expanded with evolution. To assess the cell-autonomous and species-selective properties of human glia, we engrafted human glial progenitor cells (GPCs) into neonatal immunodeficient mice. Upon maturation, the recipient brains exhibited large numbers and high proportions of both human glial progenitors and astrocytes. The engrafted human glia were gap-junction-coupled to host astroglia, yet retained the size and pleomorphism of hominid astroglia, and propagated Ca2+ signals 3-fold faster than their hosts. Long-term potentiation (LTP) was sharply enhanced in the human glial chimeric mice, as was their learning, as assessed by Barnes maze navigation, object-location memory, and both contextual and tone fear conditioning. Mice allografted with murine GPCs showed no enhancement of either LTP or learning. These findings indicate that human glia differentially enhance both activity-dependent plasticity and learning in mice. Copyright © 2013 Elsevier Inc. All rights reserved.
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Dignity is a useless concept.

              Bookmark
              • Record: found
              • Abstract: not found
              • Book: not found

              Reasons and Persons

                Bookmark

                Author and article information

                Contributors
                01612753473 , Cesar.palaciosgonzalez@postgrad.manchester.ac.uk
                Journal
                Med Health Care Philos
                Med Health Care Philos
                Medicine, Health Care, and Philosophy
                Springer Netherlands (Dordrecht )
                1386-7423
                1572-8633
                16 May 2015
                16 May 2015
                2015
                : 18
                : 4
                : 487-499
                Affiliations
                Institute for Science Ethics and Innovation, The University of Manchester, Oxford Road, Stopford Building, Room 3.383, Manchester, M13 9PL UK
                Article
                9644
                10.1007/s11019-015-9644-7
                4591198
                25981681
                3aa8ba7b-c537-4a9b-a237-fa531b1b1d5a
                © The Author(s) 2015

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

                History
                Categories
                Scientific Contribution
                Custom metadata
                © Springer Science+Business Media Dordrecht 2015

                Medicine
                chimeras,human–nonhuman chimeras,human dignity,dignity,nonhuman animals,part-human
                Medicine
                chimeras, human–nonhuman chimeras, human dignity, dignity, nonhuman animals, part-human

                Comments

                Comment on this article