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      Mechanisms of Development of Heart Failure in the Hypertensive Patient

      Cardiology

      S. Karger AG

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          Abstract

          Hypertension is a major risk factor for the development of heart failure. Mechanisms which maintain normal function in the short term in the pressure overloaded heart have longer term deleterious effects. These include left ventricular (LV) hypertrophy and chronic activation of the adrenergic and renin-angiotensin systems. β-Blocking agents are capable of blocking the adrenergic system and, to some extent, the renin-angiotensin system. They are therefore attractive in treating hypertension, both for preventing the development of abnormalities and for reversing established LV dysfunction and hypertrophy. Trials in heart failure have shown that these agents prevent progressive myocardial dysfunction, prevent and reverse remodelling and improve intrinsic systolic function. Non-selective β-blocking agents appear to offer greater anti-adrenergic effects than selective ones. However, more research is needed, including direct comparisons of different agents.

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          Most cited references 2

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          Randomised, placebo-controlled trial of carvedilol in patients with congestive heart failure due to ischaemic heart disease

            (1997)
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            The progression from hypertension to congestive heart failure

             D. Levy (1996)
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              Author and article information

              Journal
              CRD
              Cardiology
              10.1159/issn.0008-6312
              Cardiology
              S. Karger AG
              978-3-8055-7011-4
              978-3-318-00531-8
              0008-6312
              1421-9751
              1999
              November 1999
              10 December 1999
              : 92
              : Suppl 1
              : 3-6
              Affiliations
              Division of Cardiology, University Hospital, University of Colorado Health Sciences Center, Denver, Colo., USA
              Article
              47287 Cardiology 1999;92(suppl 1):3–6
              10.1159/000047287
              10652966
              © 1999 S. Karger AG, Basel

              Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

              Page count
              Figures: 3, Tables: 1, References: 7, Pages: 4
              Categories
              Paper

              General medicine, Neurology, Cardiovascular Medicine, Internal medicine, Nephrology

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