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      Epidemiology of uterine fibroids: a systematic review

      , , ,
      BJOG: An International Journal of Obstetrics & Gynaecology
      Wiley-Blackwell

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          High cumulative incidence of uterine leiomyoma in black and white women: Ultrasound evidence

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            Uterine fibroids.

            E Stewart (2001)
            Uterine leiomyomas (fibroids or myomas), benign tumours of the human uterus, are the single most common indication for hysterectomy. They are clinically apparent in up to 25% of women and cause significant morbidity, including prolonged or heavy menstrual bleeding, pelvic pressure or pain, and, in rare cases, reproductive dysfunction. Thus, both the economic cost and the effect on quality of life are substantial. Surgery has been the mainstay of fibroid treatment, and various minimally invasive procedures have been developed in addition to hysterectomy and abdominal myomectomy. Formation of new leiomyomas after these conservative therapies remains a substantial problem. Although medications that manipulate concentrations of steroid hormones are effective, side-effects limit long-term use. A better approach may be manipulation of the steroid-hormone environment with specific hormone antagonists. There has been little evidence-based evaluation of therapy. New research into the basic biology of these neoplasms may add new treatment options for the future as the role of growth factors and genetic mutations in these tumours are better understood.
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              Uterine leiomyomata: etiology, symptomatology, and management

              Fertility and Sterility, 36(4), 433-445
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                Author and article information

                Journal
                BJOG: An International Journal of Obstetrics & Gynaecology
                BJOG: Int J Obstet Gy
                Wiley-Blackwell
                14700328
                September 2017
                September 13 2017
                : 124
                : 10
                : 1501-1512
                Article
                10.1111/1471-0528.14640
                28296146
                3aac9bec-960d-47d2-ad08-bf7b6b94927e
                © 2017

                http://doi.wiley.com/10.1002/tdm_license_1.1

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