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      Call for Papers: Green Renal Replacement Therapy: Caring for the Environment

      Submit here before July 31, 2024

      About Blood Purification: 3.0 Impact Factor I 5.6 CiteScore I 0.83 Scimago Journal & Country Rank (SJR)

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      Extracorporeal CO 2 Removal Integrated within a Continuous Renal Replacement Circuit Offers Multiple Advantages

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          Abstract

          Extracorporeal CO<sub>2</sub> removal within a continuous renal replacement therapy circuit offers multiple advantages for the regulation of the CO<sub>2</sub> extraction. The authors review the impact of the dialysate solution, the buffer, and the anticoagulation on CO<sub>2</sub> removal. They propose a theoretical model of the ideal circuit for the optimization of CO<sub>2</sub> extraction.

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          Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis

          Roger C. Bone, Robert A. Balk, Frank Cerra … (1992)
          Article 0 comments Cited 340 times – based on 0 reviews     Review now
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            Tidal volume lower than 6 ml/kg enhances lung protection: role of extracorporeal carbon dioxide removal.

            Pier Paolo Terragni, Lorenzo Del Sorbo, Luciana Mascia … (2009)
            Tidal hyperinflation may occur in patients with acute respiratory distress syndrome who are ventilated with a tidal volume (VT) of 6 ml/kg of predicted body weight develop a plateau pressure (PPLAT) of 28 < or = PPLAT < or = 30 cm H2O. The authors verified whether VT lower than 6 ml/kg may enhance lung protection and that consequent respiratory acidosis may be managed by extracorporeal carbon dioxide removal. PPLAT, lung morphology computed tomography, and pulmonary inflammatory cytokines (bronchoalveolar lavage) were assessed in 32 patients ventilated with a VT of 6 ml/kg. Data are provided as mean +/- SD or median and interquartile (25th and 75th percentile) range. In patients with 28 < or = PPLAT < or = 30 cm H2O (n = 10), VT was reduced from 6.3 +/- 0.2 to 4.2 +/- 0.3 ml/kg, and PPLAT decreased from 29.1 +/- 1.2 to 25.0 +/- 1.2 cm H2O (P < 0.001); consequent respiratory acidosis (Paco2 from 48.4 +/- 8.7 to 73.6 +/- 11.1 mmHg and pH from 7.36 +/- 0.03 to 7.20 +/- 0.02; P < 0.001) was managed by extracorporeal carbon dioxide removal. Lung function, morphology, and pulmonary inflammatory cytokines were also assessed after 72 h. Extracorporeal assist normalized Paco2 (50.4 +/- 8.2 mmHg) and pH (7.32 +/- 0.03) and allowed use of VT lower than 6 ml/kg for 144 (84-168) h. The improvement of morphological markers of lung protection and the reduction of pulmonary cytokines concentration (P < 0.01) were observed after 72 h of ventilation with VT lower than 6 ml/kg. No patient-related complications were observed. VT lower than 6 ml/Kg enhanced lung protection. Respiratory acidosis consequent to low VT ventilation was safely and efficiently managed by extracorporeal carbon dioxide removal.
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              Feasibility and safety of extracorporeal CO2 removal to enhance protective ventilation in acute respiratory distress syndrome: the SUPERNOVA study

              Alain Combes, Vito Fanelli, Tài Pham … (2019)
              We assessed feasibility and safety of extracorporeal carbon dioxide removal (ECCO2R) to facilitate ultra-protective ventilation (VT 4 mL/kg and PPLAT ≤ 25 cmH2O) in patients with moderate acute respiratory distress syndrome (ARDS).
              Article 0 comments Cited 87 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (publisher-id): BPU
                Journal ID (nlm-ta): Blood Purif
                Journal ID (doi): 10.1159/issn.0253-5068
                Title: Blood Purification
                Publisher: S. Karger AG
                ISSN (Print): 0253-5068
                ISSN (Electronic): 1421-9735
                Publication date Subscription-year: 2021
                Publication date (Print): January 2021
                Publication date (Electronic): 25 June 2020
                Volume: 50
                Issue: 1
                Pages: 9-16
                Affiliations
                ICU Department, Brugmann University Hospital, Brussels, Belgium
                Author notes
                *Sebastien Redant, ICU Department, Brugmann University Hospital, Pl Van Gehuchten 4, BE–1020 Brussels (Belgium), Sebastien.Redant@CHU-Brugmann.be
                Article
                Publisher ID: 507875 Other ID: Blood Purif 2021;50:9–16
                DOI: 10.1159/000507875
                PubMed ID: 32585671
                SO-VID: 3aba51ea-a4d6-48fa-a476-5664393721e9
                Copyright © © 2020 S. Karger AG, Basel
                License:

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                History
                Date received : 11 February 2020
                Date accepted : 13 April 2020
                Page count
                Figures: 7, Tables: 2, Pages: 8
                Categories
                Subject: Review

                ScienceOpen disciplines: Cardiovascular Medicine,Nephrology
                Keywords: CO2 removal,CO2 ,Continuous renal replacement therapy,Modelization,Total,Stewaert
                Data availability:
                ScienceOpen disciplines: Cardiovascular Medicine, Nephrology
                Keywords: CO2 removal, CO2 , Continuous renal replacement therapy, Modelization, Total, Stewaert

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