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      MicroRNA-27a functions as an oncogene in gastric adenocarcinoma by targeting prohibitin.

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      Journal: Cancer Letters

      Keywords: Stomach Neoplasms, metabolism, Binding Sites, Cell Line, Tumor, Cell Transformation, Neoplastic, Disease Progression, Gene Expression Regulation, Neoplastic, Green Fluorescent Proteins, Humans, MicroRNAs, genetics, physiology, Oncogenes, Repressor Proteins, chemistry, 3' Untranslated Regions, Adenocarcinoma

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          Abstract

          MicroRNAs (miRNAs) may function as oncogenes or tumor suppressors. Here, we show that miR-27a is up-regulated in human gastric adenocarcinoma. Suppression of miR-27a inhibits gastric cancer cell growth. Subsequently, prohibitin is identified as a potential miR-27a target, combining bioinformatics and microarray analysis. EGFP report experiment also confirms that the 3' untranslated region (3'UTR) of prohibitin carries the directly binding site of miR-27a. After knockdown of miR-27a in gastric cancer cells, mRNA level and protein level of prohibitin are both elevated. Down-regulation of prohibitin by miR-27a may explain why suppression of miR-27a can inhibit gastric cancer cell growth, further supporting that miR-27a functions as an oncogene.

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          DOI:: 10.1016/j.canlet.2008.08.003
          PubMed ID:: 18789835

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          ScienceOpen disciplines: Chemistry

          Keywords: Stomach Neoplasms, metabolism, Binding Sites, Cell Line, Tumor, Cell Transformation, Neoplastic, Disease Progression, Gene Expression Regulation, Neoplastic, Green Fluorescent Proteins, Humans, MicroRNAs, genetics, physiology, Oncogenes, Repressor Proteins, chemistry, 3' Untranslated Regions, Adenocarcinoma

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