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Genetics of spondyloarthritis.

Best Practice & Research. Clinical Rheumatology

Twin Studies as Topic, pathology, genetics, epidemiology, Spondylitis, Ankylosing, Spondylarthritis, Molecular Epidemiology, Male, Major Histocompatibility Complex, Humans, Genetic Predisposition to Disease, France, Female, Family Health, Disease Models, Animal, Animals

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      Abstract

      This chapter reviews evidence from family and twin studies supporting the strong genetic predisposition of the spondyloarthritides (SpA), which is only partially attributable to the major histocompatibility locus. The current concept of SpA heterogeneity has been challenged by family studies which showed that all articular and extra-articular manifestations were linked together, and most likely to the same genetic factors.

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      Journal
      10.1016/j.berh.2006.03.002
      16777584

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