Blog
About

0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Hypernoradrenergic Innervation: Its Relationship to Functional and Hyperplastic Changes in the Vasculature of the Spontaneously Hypertensive Rat

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          There is now compelling evidence indicating that there is a greater sympathetic innervation of blood vessels in the spontaneously hypertensive rat (SHR) when compared with the innervation of corresponding vessels in the normotensive genetic control rat (WKY). In selected vascular beds in the SHR, increased sympathetic innervation occurs immediately after birth and prior to the expression of hypertension in the animal. In contrast, the available evidence suggests that the sympathetic innervation of cardiac tissue in SHR and WKY are similar in young and adult rats. The functional significance of the enhanced sympathetic innervation of blood vessels in the SHR with regard to the development or maintenance of hypertension relates in two ways to the well-established phenomena of vascular smooth muscle cell hypertrophy and hyperplasia, which are thought to be the pathophysiological basis for the increased peripheral vascular resistance and elevated blood pressure in this animal model of hypertension. First, the enhanced innervation of blood vessels in the SHR leads to an augmented release of the vasoconstrictor transmitter noradrenaline (NA). The predicted consequences of this augmented release of NA upon vascular contraction are modulated by the presence of a larger number of sites for neuronal inactivation (i.e. reuptake sites) of NA by virtue of the presence of the increased innervation. Second, and of more significance, is the inter-relationship between hypernoradrenergic innervation and vascular smooth muscle hyperplasia, as the early appearance of such changes is a powerful indicator for the subsequent expression of hypertension in the SHR. In view of the substantial evidence that implicates vascular smooth muscle cells in regulating the degree of their sympathetic innervation and confirms the influence of sympathetic nerves upon vascular smooth muscle hyperplastic change, attention is drawn to the role of trophic factors in providing the setting for the development of hypertension in the SHR.

          Related collections

          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1989
          1989
          23 September 2008
          : 26
          : 1
          : 1-20
          Affiliations
          CSIRO, Division of Human Nutrition, Hypertension Research Unit, Adelaide, Australia
          Article
          158748 Blood Vessels 1989;26:1–20
          10.1159/000158748
          © 1989 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 20
          Categories
          Review

          Comments

          Comment on this article