16
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Membrane protein architects: the role of the BAM complex in outer membrane protein assembly.

      Nature reviews. Microbiology
      Bacterial Outer Membrane Proteins, chemistry, metabolism, Escherichia coli Proteins, Gram-Negative Bacteria, Models, Molecular, Molecular Chaperones, Protein Folding, Protein Multimerization, Protein Transport

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The folding of transmembrane proteins into the outer membrane presents formidable challenges to Gram-negative bacteria. These proteins must migrate from the cytoplasm, through the inner membrane and into the periplasm, before being recognized by the beta-barrel assembly machinery, which mediates efficient insertion of folded beta-barrels into the outer membrane. Recent discoveries of component structures and accessory interactions of this complex are yielding insights into how cells fold membrane proteins. Here, we discuss how these structures illuminate the mechanisms responsible for the biogenesis of outer membrane proteins.

          Related collections

          Author and article information

          Comments

          Comment on this article