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      A case of hemophagocytic syndrome in a patient with fulminant ulcerative colitis superinfected by cytomegalovirus

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          Abstract

          Hemophagocytic syndrome (HPS) is an uncommon hematological disorder that manifests as fever, splenomegaly, and jaundice, with hemophagocytosis in the bone marrow and other tissues pathologically. Secondary HPS is associated with malignancy and infection, especially viral infection. The prevalence of cytomegalovirus (CMV) infection in ulcerative colitis (UC) patients is approximately 16%. Nevertheless, HPS in UC superinfected by CMV is very rare. A 52-year-old female visited the hospital complaining of abdominal pain and hematochezia for 6 days. She was diagnosed with UC 3 years earlier and had been treated with sulfasalazine, but had stopped her medication 4 months earlier. On admission, her spleen was enlarged. The peripheral blood count revealed pancytopenia and bone marrow aspiration smears showed hemophagocytosis. Viral studies revealed CMV infection. She was treated successfully with ganciclovir. We report this case with a review of the related literature.

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          Author and article information

          Journal
          Korean J Intern Med
          Korean J. Intern. Med
          KJIM
          The Korean Journal of Internal Medicine
          The Korean Association of Internal Medicine
          1226-3303
          2005-6648
          May 2013
          01 May 2013
          : 28
          : 3
          : 352-355
          Affiliations
          Department of Gastroenterology, Ajou University School of Medicine, Suwon, Korea.
          Author notes
          Correspondence to Sung Jae Shin, M.D. Department of Gastroenterology, Ajou University Hospital, 164 World cup-ro, Yeongtong-gu, Suwon 443-380, Korea. Tel: +82-31-219-5149, Fax: +82-31-219-5999, shsj9128@ 123456ajou.ac.kr
          Article
          10.3904/kjim.2013.28.3.352
          3654134
          23682230
          3b049307-aaf4-41e0-bbfd-15c04814eb06
          Copyright © 2013 The Korean Association of Internal Medicine

          This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

          History
          : 07 June 2011
          : 18 August 2011
          : 05 December 2011
          Categories
          Case Report

          Internal medicine
          colitis, ulcerative,inflammatory bowel diseases,cytomegalovirus infections,lymphohistiocytosis, hemophagocytic

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