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HBV transmission from an occult carrier with five mutations in the major hydrophilic region of HBsAg to an immunosuppressed plasma recipient.
Nicola Coppola
1 ,
Giovanna Loquercio ,
Gilda Tonziello ,
Rosa Azzaro ,
Mariantonietta Pisaturo ,
Gaetano Di Costanzo ,
Mario Starace ,
Giuseppe Pasquale ,
Carmela Cacciapuoti ,
Arnolfo Petruzziello
Sep 2013
ALT,
HBIG,
HBV,
HBV infection,
HBsAg,
HBsAg mutants,
MHR,
NAT,
OBI,
Occult HBV infection,
PC,
Transfusion,
alanine amino-transferase,
hepatitis B immunoglobulin,
hepatitis B surface antigen,
hepatitis B virus,
major hydrophilic region,
nucleic acid amplification technique,
occult HBV infection,
polymerase chain reaction
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Abstract
We describe the case of transmission of an HBsAg-negative hepatitis B infection to an immunosuppressed patient by plasma donation from an HBsAg-negative subject, but with very low serum HBV DNA (about 50 IU/ml) and five mutations in the major hydrophilic region of HBsAg.
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Author and article information
ALT,HBIG,HBV,HBV infection,HBsAg,HBsAg mutants,MHR,NAT,OBI,Occult HBV infection,PC,Transfusion,alanine amino-transferase,hepatitis B immunoglobulin,hepatitis B surface antigen,hepatitis B virus,major hydrophilic region,nucleic acid amplification technique,occult HBV infection,polymerase chain reaction
ALT, HBIG, HBV, HBV infection, HBsAg, HBsAg mutants, MHR, NAT, OBI, Occult HBV infection, PC, Transfusion, alanine amino-transferase, hepatitis B immunoglobulin, hepatitis B surface antigen, hepatitis B virus, major hydrophilic region, nucleic acid amplification technique, occult HBV infection, polymerase chain reaction