Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication. With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the characteristics of producer cells, exosomes can be utilized as cell-free therapeutics. Among exosomes derived from various cellular origins, mesenchymal stem cell-derived exosomes (MSC-exosomes) have gained great attention due to their immunomodulatory and regenerative functions. Indeed, many studies have shown anti-inflammatory, anti-aging and wound healing effects of MSC-exosomes in various in vitro and in vivo models. In addition, recent advances in the field of exosome biology have enabled development of specific guidelines and quality control methods, which will ultimately lead to clinical application of exosomes. This review highlights recent studies that investigate therapeutic potential of MSC-exosomes and relevant mode of actions for skin diseases, as well as quality control measures required for development of exosome-derived therapeutics.

Related collections

Most cited references 225

Record: found
Abstract: found
Article: not found

Inflammation in wound repair: molecular and cellular mechanisms.

Sabine A. Eming, Thomas Krieg, Jeffrey Davidson (2007)

In post-natal life the inflammatory response is an inevitable consequence of tissue injury. Experimental studies established the dogma that inflammation is essential to the establishment of cutaneous homeostasis following injury, and in recent years information about specific subsets of inflammatory cell lineages and the cytokine network orchestrating inflammation associated with tissue repair has increased. Recently, this dogma has been challenged, and reports have raised questions on the validity of the essential prerequisite of inflammation for efficient tissue repair. Indeed, in experimental models of repair, inflammation has been shown to delay healing and to result in increased scarring. Furthermore, chronic inflammation, a hallmark of the non-healing wound, predisposes tissue to cancer development. Thus, a more detailed understanding in mechanisms controlling the inflammatory response during repair and how inflammation directs the outcome of the healing process will serve as a significant milestone in the therapy of pathological tissue repair. In this paper, we review cellular and molecular mechanisms controlling inflammation in cutaneous tissue repair and provide a rationale for targeting the inflammatory phase in order to modulate the outcome of the healing response.

0 comments Cited 576 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair--current views.

Donald G. Phinney, Darwin J. Prockop (2007)

Mesenchymal stem cells or multipotent stromal cells (MSCs) isolated from the bone marrow of adult organisms were initially characterized as plastic adherent, fibroblastoid cells with the capacity to generate heterotopic osseous tissue when transplanted in vivo. In recent years, MSCs or MSC-like cells have been shown to reside within the connective tissue of most organs, and their surface phenotype has been well described. A large number of reports have also indicated that the cells possess the capacity to transdifferentiate into epithelial cells and lineages derived from the neuroectoderm. The broad developmental plasticity of MSCs was originally thought to contribute to their demonstrated efficacy in a wide variety of experimental animal models of disease as well as in human clinical trials. However, new findings suggest that the ability of MSCs to alter the tissue microenvironment via secretion of soluble factors may contribute more significantly than their capacity for transdifferentiation in tissue repair. Herein, we critically evaluate the literature describing the plasticity of MSCs and offer insight into how the molecular and functional heterogeneity of this cell population, which reflects the complexity of marrow stroma as an organ system, may confound interpretation of their transdifferentiation potential. Additionally, we argue that this heterogeneity also provides a basis for the broad therapeutic efficacy of MSCs.

0 comments Cited 479 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: found

Is Open Access

Senescence and aging: Causes, consequences, and therapeutic avenues

Domhnall McHugh, Jesus Gil (2018)

McHugh and Gil review the role of senescence in age-related diseases and how targeting senescence may improve health span and extend life span.

0 comments Cited 414 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Journal ID (nlm-ta): Cells

Journal ID (iso-abbrev): Cells

Journal ID (publisher-id): cells

Title: Cells

Publisher: MDPI

ISSN (Electronic): 2073-4409

Publication date (Electronic): 07 May 2020

Publication date Collection: May 2020

Volume: 9

Issue: 5

Electronic Location Identifier: 1157

Affiliations

[1 ]ExoCoBio Exosome Institute (EEI), ExoCoBio Inc., Seoul 08594, Korea; dh.ha@ 123456exocobio.com (D.H.H.); hyunkeun.kim@ 123456exocobio.com (H.-k.K.); junho.lee@ 123456exocobio.com (J.H.L.); sumi.sung@ 123456exocobio.com (S.S.)

[2 ]School of Chemical and Biological Engineering, Seoul National University, Seoul 08826, Korea; purequill@ 123456naver.com

[3 ]Oaro Dermatology Clinic, Seoul 13620, Korea; banbury@ 123456hanmail.net

[4 ]Department of Dermatology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwasweong-si, Gyeonggi-do 18450, Korea; jin66666@ 123456hanmail.net

[5 ]Guam Dermatology Institute, Tamuning, GU 96913, USA; guamderm@ 123456gmail.com

[6 ]Oaro Dermatology Clinic, Seoul 01695, Korea; jaeyoon007@ 123456hanmail.net

[7 ]Piena Clinic, Seoul 06120, Korea; hosungeee@ 123456naver.com

Author notes

[* ]Correspondence: yongweon.yi@ 123456exocobio.com (Y.W.Y.); ceo@ 123456exocobio.com (B.S.C.); Tel.: +82-2-2038-3915 (B.S.C.)

[†]

These authors contributed equally to this article.

Author information

Hyun-keun Kim https://orcid.org/0000-0002-5801-1920

Yong Weon Yi https://orcid.org/0000-0001-6895-0465

Article

Publisher ID: cells-09-01157

DOI: 10.3390/cells9051157

PMC ID: 7290908

PubMed ID: 32392899

SO-VID: 3b15b853-6357-44f3-aa11-7099a83aaa71

License:

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration

Read this article at

Abstract

Related collections

Universal stem cells

Most cited references 225

Inflammation in wound repair: molecular and cellular mechanisms.

Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair--current views.

Senescence and aging: Causes, consequences, and therapeutic avenues

Author and article information

Journal

Affiliations

Author notes

Author information

Article

History

Categories

Comments

Comment on this article

Similar content 573

Cited by 140

Most referenced authors 5,881