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      Cellular and molecular pathways linking inflammation and cancer

      , , , , , ,
      Immunobiology
      Elsevier BV

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          Abstract

          Several experimental and epidemiological evidence indicate that, irrespective of the trigger for the development (chronic infection/inflammation or genetic alteration), a "smouldering" inflammation is associated with the most of, if not all, tumours and supports their progression. Several evidence have highlighted that tumours promote a constant influx of myelomonocytic cells that express inflammatory mediators supporting pro-tumoral functions. Myelomonocytic cells are key orchestrators of cancer-related inflammation associated with proliferation and survival of malignant cells, subversion of adaptive immune response, angiogenesis, stroma remodelling and metastasis formation. Although the connection between inflammation and cancer is unequivocal the mechanistic basis of such association are largely unknown. Recent advances in the understanding of the cellular and molecular pathways involved in cancer-related inflammation as well as their potential relevance as diagnostic, prognostic and therapeutic targets are herein discussed.

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          Author and article information

          Journal
          Immunobiology
          Immunobiology
          Elsevier BV
          01712985
          September 2009
          September 2009
          : 214
          : 9-10
          : 761-777
          Article
          10.1016/j.imbio.2009.06.014
          19616341
          3b2fb348-3fb6-440d-80f7-2ef21ffa5724
          © 2009

          https://www.elsevier.com/tdm/userlicense/1.0/

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