+1 Recommend
0 collections
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Protective Effect of Bacoside-A against Morphine-Induced Oxidative Stress in Rats


      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          In the present study, we investigated the protective effect of bacoside-A the active principle isolated from the plant Bacopa monniera against oxidative damage induced by morphine in rat brain. Morphine intoxicated rats received 10-160 mg/kg b.w. of morphine hydrochloride intraperitoneally for 21 days. Bacoside-A pretreated rats were administered with bacoside-A (10 mg/kg b.w/day) orally, 2 h before the injection of morphine for 21 days. Pretreatment with bacoside-A has shown to possess a significant protective role against morphine induced brain oxidative damage in the antioxidant status (total reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase and lipid peroxidation) and membrane bound ATP-ases(Na +/K +ATPase. Ca 2+ and Mg 2+ ATPases) activities in rat. The results of the present study indicate that bacoside-A protects the brain from oxidative stress induced by morphine.

          Related collections

          Most cited references54

          • Record: found
          • Abstract: found
          • Article: not found

          Selenium: biochemical role as a component of glutathione peroxidase.

          When hemolyzates from erythrocytes of selenium-deficient rats were incubated in vitro in the presence of ascorbate or H(2)O(2), added glutathione failed to protect the hemoglobin from oxidative damage. This occurred because the erythrocytes were practically devoid of glutathione-peroxidase activity. Extensively purified preparations of glutathione peroxidase contained a large part of the (75)Se of erythrocytes labeled in vivo. Many of the nutritional effects of selenium can be explained by its role in glutathione peroxidase.
            • Record: found
            • Abstract: not found
            • Article: not found

            Determination of carbonyl content in oxidatively modified proteins.

              • Record: found
              • Abstract: found
              • Article: not found

              Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver.

              Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver have been investigated. After perfusing the lung to remove contaminating blood, this organ was found to have an apparent concentration of glutathione (2mM) which is approx. 20% of that found in the liver. Both organs contain very low levels of glutathione disulfide. Neither phenobarbital nor methylcholanthrene had a significant effect on the levels of reduced glutathione in lung and liver. In addition, the activities of some glutathione-metabolizing enzymes--glutathione reductase and glutathione S-transferase activity assayed with four different substrates--were observed to be 5-to 60-fold lower in lung tissue than in the liver.

                Author and article information

                Indian J Pharm Sci
                Indian J Pharm Sci
                Indian Journal of Pharmaceutical Sciences
                Medknow Publications & Media Pvt Ltd (India )
                Jul-Aug 2011
                : 73
                : 4
                : 409-415
                [1]Department of Medical Biochemistry, Dr. A. L. M. Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600 113, India
                Author notes
                [* ] Address for correspondence E-mail: sumsthangarajan@ 123456gmail.com
                Copyright: © Indian Journal of Pharmaceutical Sciences

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                : 19 January 2010
                : 11 July 2011
                : 20 July 2011
                Research Paper

                Pharmacology & Pharmaceutical medicine
                oxidative stress,brain damage,morphine,membrane-bound atpases,bacoside-a


                Comment on this article