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      Activation of Tubuloglomerular Feedback in Rat Nephrons by Sera from Rabbits with Fulminant Hepatic Failure

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          Abstract

          Experiments were designed to determine whether substance(s) other than electrolytes might activate tubuloglomerular feedback in experimental fulminant hepatic failure. Severe hepatic damage and renal dysfunction were induced by intravenous administration of D-galactosamine. Sera from normal or D-galactosamine-treated rabbits were dialyzed against glucose solution to reduce electrolyte concentrations. Tubuloglomerular feedback response was evaluated in rat nephrons by measuring the early proximal flow rate (EPFR) during orthograde perfusion of the loop of Henle. EPFR was reduced by 28 and 48% with Ringer’s solution and sera from D-galactosamine-treated rabbits, respectively, but was not altered by normal sera. Substance(s) other than electrolytes in the sera from D-galactosamine-treated rabbits might activate the tubuloglomerular feedback to reduce glomerular filtration.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1983
          1983
          03 December 2008
          : 35
          : 2
          : 136-139
          Affiliations
          First Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa, Japan
          Article
          183062 Nephron 1983;35:136–139
          10.1159/000183062
          6621757
          © 1983 S. Karger AG, Basel

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          Page count
          Pages: 4
          Categories
          Original Paper

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