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      An integrated expression atlas of miRNAs and their promoters in human and mouse

      Author(s): , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , The FANTOM Consortium
      Publication date (Electronic):
      Journal: Nature Biotechnology
      Publisher: Springer Science and Business Media LLC

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          Abstract

          An atlas of microRNA expression patterns and regulators is produced by deep sequencing of short RNAs in human and mouse cells.

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          The operated Markov´s chains in economy (discrete chains of Markov with the income)

          Grigoriy Sokolov (2015)
          Book 0 comments Cited 5168 times – based on 0 reviews
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            The transcriptional landscape of the mammalian genome.

            P Carninci, T Kasukawa, S. Katayama … (2005)
            This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.
            Article 0 comments Cited 1279 times – based on 0 reviews     Review now
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              RNA maps reveal new RNA classes and a possible function for pervasive transcription.

              Philipp Kapranov, Jill Cheng, Sujit Dike … (2007)
              Significant fractions of eukaryotic genomes give rise to RNA, much of which is unannotated and has reduced protein-coding potential. The genomic origins and the associations of human nuclear and cytosolic polyadenylated RNAs longer than 200 nucleotides (nt) and whole-cell RNAs less than 200 nt were investigated in this genome-wide study. Subcellular addresses for nucleotides present in detected RNAs were assigned, and their potential processing into short RNAs was investigated. Taken together, these observations suggest a novel role for some unannotated RNAs as primary transcripts for the production of short RNAs. Three potentially functional classes of RNAs have been identified, two of which are syntenically conserved and correlate with the expression state of protein-coding genes. These data support a highly interleaved organization of the human transcriptome.
              Article 0 comments Cited 989 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Title: Nature Biotechnology
                Abbreviated Title: Nat Biotechnol
                Publisher: Springer Science and Business Media LLC
                ISSN (Print): 1087-0156
                ISSN (Electronic): 1546-1696
                Publication date Created: September 2017
                Publication date (Electronic): August 21 2017
                Publication date (Print): September 2017
                Volume: 35
                Issue: 9
                Pages: 872-878
                Article
                DOI: 10.1038/nbt.3947
                PMC ID: 5767576
                PubMed ID: 28829439
                SO-VID: 3b6f4d23-cded-40b5-b9c9-2c16ca292b86
                Copyright © © 2017
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                http://www.springer.com/tdm

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