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      No Survival Difference with Neoadjuvant Chemoradiotherapy Compared with Chemotherapy in Resectable Esophageal and Gastroesophageal Junction Adenocarcinoma: Results from the National Cancer Data Base.

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          Abstract

          Neoadjuvant treatment improves survival in resectable esophageal adenocarcinoma, but the optimal regimen has not been defined. Neoadjuvant chemoradiation (nCRT) is associated with higher pathologic complete response (pCR) relative to chemotherapy (nCTX), but has not been shown to improve survival; however, previous studies have been underpowered to demonstrate a survival difference. The objective of this study was to determine if nCRT is associated with increased survival relative to nCTX in patients with resectable esophageal adenocarcinoma.

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          Author and article information

          Journal
          J. Am. Coll. Surg.
          Journal of the American College of Surgeons
          Elsevier BV
          1879-1190
          1072-7515
          Dec 2016
          : 223
          : 6
          Affiliations
          [1 ] Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY.
          [2 ] Department of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, NY.
          [3 ] Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY. Electronic address: steven.hochwald@roswellpark.org.
          Article
          S1072-7515(16)31400-4
          10.1016/j.jamcollsurg.2016.09.002
          27641320
          3b733ee5-62e2-4c73-a916-e2d34a9b932d
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