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      Vasodilator Effect of Thrombins Prepared from Normal or Deficient Human or Canine Plasmas

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          Thrombins prepared from plasmas deficient in various clotting factors are capable of inducing vasodilator response to the hindlimb of the dog and this response proved to be similar to that produced by thrombins prepared from normal plasmas. Thus the vascular effect of thrombin is not mediated by any other clotting factor which might be present in small amounts in the thrombin preparations. Thrombin prepared from canine normal plasma exerted a more potent vasodilator response, indicating a species specificity for the vascular response to thrombin. Since the vasodilating effect of thrombin is not mediated by (i) a nervous mechanism, (ii) any known vasodilating substance or (iii) any other clotting factor, it is concluded that the thrombin moiety possesses vasodilating properties.

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          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          18 September 2008
          : 13
          : 3
          : 181-192
          Department of Physiology, Northwest Center for Medical Education, Indiana University School of Medicine, Gary, Ind., University of North Carolina, School of Medicine, Chapel Hill, N.C., and University of Nebraska Medical Center, Omaha, Nebr.
          158088 Blood Vessels 1976;13:181–192
          © 1976 S. Karger AG, Basel

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          Pages: 12
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