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      Cranberry proanthocyanidins improve the gut mucous layer morphology and function in mice receiving elemental enteral nutrition.

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          Abstract

          Lamina propria Th2 cytokines, interleukin (IL)-4 and IL-13, stimulate goblet cell (GC) proliferation and MUC2 production, which protect the intestinal mucosa. Elemental enteral nutrition (EEN) reduces tissue IL-4 and impairs barrier function. Proanthocyanidins (PACs) stimulate oral mucin levels. We hypothesized that adding PAC to EEN would maintain Th2-without stimulating Th1-cytokines and preserve luminal MUC2 vs EEN alone.

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          Author and article information

          Journal
          JPEN J Parenter Enteral Nutr
          JPEN. Journal of parenteral and enteral nutrition
          SAGE Publications
          0148-6071
          0148-6071
          October 16 2012
          : 37
          : 3
          Affiliations
          [1 ] Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
          Article
          0148607112463076 NIHMS717488
          10.1177/0148607112463076
          4564871
          23064255
          3bbe8839-825d-495e-90fb-9d8849c8d3df
          History

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