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      36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016

      abstract
      1 , 1 , 1 , , 2 , 2 , 2 , 2 , 3 , 4 , 2 , 5 , 6 , 2 , 7 , 8 , 8 , 8 , 8 , 9 , 10 , 11 , 9 , 10 , 10 , 10 , 12 , 10 , 13 , 13 , 14 , 15 , 15 , 15 , 15 , 15 , 15 , 15 , 16 , 15 , 15 , 17 , 18 , 17 , 17 , 17 , 19 , 19 , 19 , 19 , 19 , 19 , 19 , 19 , 20 , 20 , 20 , 20 , 20 , 21 , 22 , 23 , 24 , 25 , 23 , 24 , 26 , 26 , 27 , 27 , 27 , 27 , 28 , 28 , 28 , 28 , 28 , 28 , 28 , 28 , 28 , 28 , 29 , 30 , 30 , 30 , 30 , 30 , 29 , 31 , 31 , 31 , 31 , 31 , 31 , 32 , 32 , 32 , 32 , 32 , 33 , 34 , 35 , 33 , 35 , 33 , 34 , 33 , 36 , 36 , 36 , 36 , 36 , 36 , 36 , 37 , 38 , 39 , 37 , 40 , 41 , 37 , 42 , 43 , 42 , 37 , 44 , 37 , 45 , 45 , 46 , 46 , 47 , 47 , 48 , 48 , 48 , 48 , 48 , 49 , 49 , 49 , 49 , 49 , 49 , 50 , 50 , 51 , 52 , 52 , 52 , 52 , 52 , 52 , 52 , 52 , 53 , 53 , 53 , 53 , 53 , 53 , 53 , 53 , 54 , 54 , 54 , 54 , 55 , 54 , 54 , 56 , 56 , 56 , 56 , 57 , 58 , 56 , 59 , 59 , 59 , 59 , 59 , 60 , 61 , 62 , 61 , 61 , 63 , 63 , 63 , 63 , 63 , 63 , 63 , 64 , 64 , 64 , 64 , 64 , 64 , 64 , 65 , 65 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, 707 , 707 , 708 , 708 , 708 , 709 , 709 , 709 , 710 , 711 , 711 , 712 , 712 , 712 , 712 , 712 , 713 , 714 , 714 , 713 , 713 , 713 , 714 , 715 , 715 , 715 , 715 , 715 , 715 , 715 , 715 , 715 , 715 , 716 , 716 , 716 , 716 , 716 , 716 , 716 , 716 , 716 , 716 , 716 , 716 , 717 , 717 , 717 , 718 , 718 , 718 , 718 , 719 , 719 , 719 , 720 , 721 , 722 , 723 , 724 , 725 , 726 , 726 , 726 , 726 , 727 , 727 , 728 , 729 , 730 , 730 , 730 , 730 , 731 , 731 , 731 , 731 , 732 , 733 , 734 , 735 , 736 , 736 , 737 , 732 , 732 , 732 , 738 , 738 , 739 , 739 , 740 , 739 , 741 , 742 , 742 , 742 , 742 , 742 , 742 , 743 , 743 , 743 , 743 , 743 , 743 , 743 , 744 , 744 , 744 , 745 , 745 , 744 , 744 , 745 , 746 , 746 , 746 , 747 , 747 , 747 , 748 , 748 , 748 , 748 , 748 , 748 , 748 , 748 , 748 , 748 , 749 , 749 , 750 , 750 , 750 , 750 , 750 , 751 , 751 , 752 , 752 , 753 , 753 , 753 , 754 , 753 , 755 , 756 , 757 , 757 , 758 , 759 , 759 , 759 , 759 , 759 , 759 , 760 , , 760 , 760 , 760 , 760 , 760 , 760 , 760 , 760 , 760 , 760 , 760 , 761 , 761 , 761 , 761 , 761 , 761 , 762 , 762 , 762 , 763 , 763 , 763 , 763 , , 763 , 763 , 763 , 763 , 764 , 764 , 764 , 764 , 764 , 764 , 764 , 764 , 765 , 765 , 765 , 765 , 766 , 766 , 766 , 766 , 766 , 766 , 767 , 1 , 768 , 768 , 768 , 768 , 769 , 769 , 770 , 771 , 772 , 771 , 771 , 773 , 773 , 774 , 774 , , 775 , 776 , 776 , 776 , 776 , 776 , 777 , 777 , 777 , 777 , 778 , 779 , 780 , 780 , 781 , 781 , 781 , 782 , 782 , 782 , 782 , 782 , 781 , 781 , 781 , , , 784 , 785 , 783 , , , S South Yorkshire Hospitals Research Collaboration, 786 , 787 , 787 , 788 , 787 , 787 , 787 , 787 , 789 , 790 , 790 , 791 , 792 , 793 , 794 , 794 , 795 , 794 , 796 , 796 , 796 , 797 , 798 , 797 , 799 , 800 , 801 , 802 , 803 , 801 , 804 , 804 , 804 , 804 , 804 , 804 , 805 , 805 , 805 , 806 , 806 , 807 , 807 , 807 , 807 , 808 , , 808 , 809 , 809 , 809 , 809 , 809 , 809 , 810 , 811 , 811 , 811 , 812 , 813 , 814 , 814 , 815 , 815 , 815 , 815 , 816 , 816 , 816 , 816 , 817 , 817 , 817 , 817 , 817 , 817 , 817 , 817 , 817 , 817 , 818 , 819 , 819 , 818 , 820 , 821 , 819 , 822 , 822 , 823 , 823 , 823 , 824 , 824 , 825 , 826 , 824 , 827 , 828 , 827 , 827 , 829 , 829 , 829 , 830 , 831 , 831 , 831 , 831 , 830 , 832 , 832 , 832 , 833 , 832 , 832 , 833 , 834 , 834 , 834 , 834 , 834 , 835 , 836 , 835 , 835
      Critical Care
      BioMed Central
      36th International Symposium on Intensive Care and Emergency Medicine
      15-18 March 2016

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          Table of contents

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          R. M. Bateman, M. D. Sharpe, J. E. Jagger, C. G. Ellis

          P002 - Lower serum immunoglobulin G2 level does not predispose to severe flu.

          J. Solé-Violán, M. López-Rodríguez, E. Herrera-Ramos, J. Ruíz-Hernández, L. Borderías, J. Horcajada, N. González-Quevedo, O. Rajas, M. Briones, F. Rodríguez de Castro, C. Rodríguez Gallego

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          R. Riff, O. Naamani, A. Douvdevani

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          S. Ono, T. Kubo, S. Suda, T. Ueno, T. Ikeda

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          T. Hirose, H. Ogura, H. Takahashi, M. Ojima, J. Kang, Y. Nakamura, T. Kojima, T. Shimazu

          P008 - Comparison of bacteremia and sepsis on sepsis related biomarkers

          T. Ikeda, S. Suda, Y. Izutani, T. Ueno, S. Ono

          P009 - The changes of procalcitonin levels in critical patients with abdominal septic shock during blood purification

          T. Taniguchi, M. O

          P010 - Validation of a new sensitive point of care device for rapid measurement of procalcitonin

          C. Dinter, J. Lotz, B. Eilers, C. Wissmann, R. Lott

          P011 - Infection biomarkers in primary care patients with acute respiratory tract infections – Comparison of procalcitonin and C-reactive protein

          M. M. Meili, P. S. Schuetz

          P012 - Do we need a lower procalcitonin cut off?

          H. Hawa, M. Sharshir, M. Aburageila, N. Salahuddin

          P013 - The predictive role of C-reactive protein and procalcitonin biomarkers in central nervous system infections with extensively drug resistant bacteria

          V. Chantziara, S. Georgiou, A. Tsimogianni, P. Alexandropoulos, A. Vassi, F. Lagiou, M. Valta, G. Micha, E. Chinou, G. Michaloudis

          P014 - Changes in endotoxin activity assay and procalcitonin levels after direct hemoperfusion with polymyxin-b immobilized fiber

          A. Kodaira, T. Ikeda, S. Ono, T. Ueno, S. Suda, Y. Izutani, H. Imaizumi

          P015 - Diagnostic usefullness of combination biomarkers on ICU admission

          M. V. De la Torre-Prados, A. Garcia-De la Torre, A. Enguix-Armada, A. Puerto-Morlan, V. Perez-Valero, A. Garcia-Alcantara

          P016 - Platelet function analysis utilising the PFA-100 does not predict infection, bacteraemia, sepsis or outcome in critically ill patients

          N. Bolton, J. Dudziak, S. Bonney, A. Tridente, P. Nee

          P017 - Extracellular histone H3 levels are inversely correlated with antithrombin levels and platelet counts and are associated with mortality in sepsis patients

          G. Nicolaes, M. Wiewel, M. Schultz, K. Wildhagen, J. Horn, R. Schrijver, T. Van der Poll, C. Reutelingsperger

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          S. Pillai, G. Davies, G. Mills, R. Aubrey, K. Morris, P. Williams, P. Evans

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          E. G. Gayat, J. Struck, A. Cariou, N. Deye, B. Guidet, S. Jabert, J. Launay, M. Legrand, M. Léone, M. Resche-Rigon, E. Vicaut, A. Vieillard-Baron, A. Mebazaa

          P020 - Impact of disease severity assessment on performance of heparin-binding protein for the prediction of septic shock

          R. Arnold, M. Capan, A. Linder, P. Akesson

          P021 - Kinetics and prognostic value of presepsin (sCD14) in septic patients. A pilot study

          M. Popescu, D. Tomescu

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          C. L. Sprung, R. Calderon Morales, G. Munteanu, E. Orenbuch-Harroch, P. Levin, H. Kasdan, A. Reiter, T. Volker, Y. Himmel, Y. Cohen, J. Meissonnier

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          L. Girard, F. Rebeaud

          P024 - How nanotechnology-based approaches could contribute to sepsis prevention, diagnosis and treatment

          I. Herrmann

          P025 - Il7r transcriptional expression analysis during septic shock

          B. Delwarde, E. Peronnet, E. Cerrato, F. Venet, A. Lepape, T. Rimmelé, G. Monneret, J. Textoris

          P026 - Disbalance of microbial metabolites of aromatic acids affects the severity in critically ill patients

          N. Beloborodova, V. Moroz, A. Osipov, A. Bedova, Y. Sarshor, A. Pautova, A. Sergeev, E. Chernevskaya

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          J. Odermatt, R. Bolliger, L. Hersberger, M. Ottiger, M. Christ-Crain, B. Mueller, P. Schuetz

          P028 - Identification of differential proteomic response in septic patients secondary to community and hospital acquired pneumonia

          N. K. Sharma, A. K. Tashima, M. K. Brunialti, F. R. Machado, M. Assuncao, O. Rigato, R. Salomao

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          S. C. Cajander, G. Rasmussen, E. Tina, B. Söderquist, J. Källman, K. Strålin

          P030 - Soluble B- and T-lymphocyte attenuator: A possible prognostic marker in sepsis

          A. L. Lange, J. S. Sundén-Cullberg, A. M. Magnuson, O. H. Hultgren

          P031 - Fractal dimension: A new biomarker for quantifying clot microstructure in patients across the sepsis spectrum

          G. Davies, S. Pillai, G. Mills, R. Aubrey, K. Morris, P. Williams, P. Evans

          P032 - Comparison between the new biomarker for coagulation, clot microstructure (Df) with rotational thromboelastometry (ROTEM) in patients across the sepsis spectrum

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          R. Tincu, C. Cobilinschi, D. Tomescu, Z. Ghiorghiu, R. Macovei

          P040 - Host response and outcome of hypothermic sepsis

          M. A. Wiewel, M. B. Harmon, L. A. Van Vught, B. P. Scicluna, A. J. Hoogendijk, J. Horn, A. H. Zwinderman, O. L. Cremer, M. J. Bonten, M. J. Schultz, T. Van der Poll, N. P. Juffermans, W. J. Wiersinga

          P041 - Septic shock alert over SIRS criteria has an impact on outcome but needs to be revised

          G. Eren, Y Tekdos, M. Dogan, O. Acicbe, E. Kaya, O. Hergunsel

          P042 - Association between previous prescription of βblockers and mortality rate among septic patients: A retrospective observational study

          S. Alsolamy, G. Ghamdi, L. Alswaidan, S. Alharbi, F. Alenezi, Y. Arabi

          P043 - Recognition and treatment of sepsis on labour ward– teaching & information resources can improve knowledge

          J. Heaton, A. Boyce, L. Nolan, J. Johnston, A. Dukoff-Gordon, A. Dean, A. Molokhia

          P044 - Culture negative sepsis in the ICU – what is unique to this patient population?

          T. Mann Ben Yehudah

          P045 - Organ dysfunction in severe sepsis patients identified in administrative data in Germany, 2007-2013

          C. Fleischmann, D. Thomas-Rueddel, C. Haas, U. Dennler, K. Reinhart

          P046 - A comparison of residents’ knowledge regarding; the Surviving Sepsis Campaign 2012 guideline

          O. Suntornlohanakul, B. Khwannimit

          P047 - Effectiveness of a septic shock bundle to improve outcomes in the ICU

          F. Breckenridge, A. Puxty

          P048 - Dose of norepinephrine in the first 24 hours as a parameter evaluating the effectiveness of treatment in patients with severe sepsis and septic shock

          P. Szturz, P. Folwarzcny, J. Svancara, R. Kula, P. Sevcik

          P049 - Norepinephrine or vasopressin + norepinephrine in septic shock. A retrospective series of 39 patients

          L. Caneva, A. Casazza, E. Bellazzi, S. Marra, L. Pagani, M. Vetere, R. Vanzino, D. Ciprandi, R. Preda, R. Boschi, L. Carnevale

          P050 - Methylene blue effectiveness as contributory treatment in patients with septic shock

          V. Lopez, M. Aguilar Arzapalo, L. Barradas, A. Escalante, J. Gongora, M. Cetina

          P051 - Coagulation disorders in patients with severe sepsis and DIC evaluated with thromboelastometry.

          B Adamik, D Jakubczyk, A Kübler

          P052 - Frequency and outcome of early sepsis-associated coagulopathy

          A. Radford, T. Lee, J. Singer, J. Boyd, D. Fineberg, M. Williams, J. Russell

          P053 - Assessment of coagulopathy in cancer patients with severe sepsis or septic shock. A case-control pilot study

          E. Scarlatescu, D. Tomescu, G. Droc, S. Arama

          P054 - Thromboelastometry in critically ill patients with disseminated intravascular coagulation

          M. Müller, M. Straat, S. S. Zeerleder, N. P. Juffermans

          P055 - Cessation of a preexisting chronic antiplatelet therapy is associated with increased mortality rates in severe sepsis and septic shock

          C. F. Fuchs, C. S. Scheer, S. W. Wauschkuhn, M. V. Vollmer, K. M. Meissner, S. K. Kuhn, K. H. Hahnenkamp, S. R. Rehberg, M. G. Gründling

          P056 - Neutrophil Extracellular Traps (NETs) production under hypoxic condition

          N. Yamamoto, M. Ojima, S. Hamaguchi, T. Hirose, Y. Akeda, R. Takegawa, O. Tasaki, T. Shimazu, K. Tomono

          P057 - Impact of ultraviolet air sterilizer in intensive care unit room, and clinical outcomes of patients

          E. Gómez-Sánchez, M. Heredia-Rodríguez, E. Álvarez-Fuente, M. Lorenzo-López, E. Gómez-Pesquera, M. Aragón-Camino, P. Liu-Zhu, A. Sánchez-López, A. Hernández-Lozano, M. T. Peláez-Jareño, E. Tamayo

          P058 - Focus of infection in severe sepsis - comparison of administrative data and prospective cohorts from Germany

          D. O. Thomas-Rüddel, C. Fleischmann, C. Haas, U. Dennler, K. Reinhart

          P059 - “Zero CLABSI” – can we get there? Obstacles on the 4 year journey and our strategies to overcome them – experience from an Indian ICU

          V. Adora, A. Kar, A. Chakraborty, S. Roy, A. Bandyopadhyay, M. Das

          P060 - Novel molecular techniques to identify central venous catheter (CVC) associated blood stream infections (BSIs)

          T. Mann Ben Yehudah, G. Ben Yehudah, M. Salim, N. Kumar, L. Arabi, T. Burger, P. Lephart, E. Toth-martin

          P061 - Zero clabsi” – can we get there? Obstacles on the 4 year journey and our strategies to overcome them – experience from an Indian ICU

          R. Rao, A. Kar, A. Chakraborty

          P062 - Prevention of central line-associated bloodstream infections in intensive care units: An international online survey

          C. Valencia, N. Hammami, S. Blot, J. L. Vincent, M. L. Lambert

          P063 - 30 days antimicrobial efficacy of non-leaching central venous catheters

          J. Brunke, T. Riemann, I. Roschke

          P064 - Efficacy of noble metal alloy-coated catheter in prevention of bacteriuria

          R. Tincu, C. Cobilinschi, D. Tomescu, Z. Ghiorghiu, R. Macovei

          P065 - Predicting bacteremic urinary tract infection in community setting: A prospective observational study

          S. Nimitvilai, K. Jintanapramote, S. Jarupongprapa

          P066 - Eight-year analysis of acinetobacter spp. monobacteremia in surgical and medical intensive care units at university hospital in Lithuania

          D. Adukauskiene, D. Valanciene

          P067 - Group A and group B streptococcal infections in intensive care unit – our experience in a tertiary centre

          G. Bose, V. Lostarakos, B. Carr

          P068 - Improved detection of spontaneous bacterial peritonitis by uritop + tm strip test and inoculation of blood culture bottles with ascitic fluid

          S. Khedher, A. Maaoui, A. Ezzamouri, M. Salem

          P069 - Increased risk of cellulitis in patients with congestive heart failure: a population based cohort study

          J. Chen

          P070 - Outcomes of severe cellulitis and necrotizing fasciitis in the critically ill

          D. R. Cranendonk, L. A. Van Vught, M. A. Wiewel, O. L. Cremer, J. Horn, M. J. Bonten, M. J. Schultz, T. Van der Poll, W. J. Wiersinga

          P071 - Botulism outbreak associated with people who inject drugs (PWIDs) in Scotland.

          M. Day, G. Penrice, K. Roy, P. Robertson, G. Godbole, B. Jones, M. Booth, L. Donaldson

          P072 - Surveillance of ESBL-producing enterobacteriaceae fecal carriers in the ICU

          Y. Kawano, H. Ishikura

          P073 - Prevalence of ESBL and carbapenemase producing uropathogens in a newly opened hospital in south India

          S. Sreevidya, N. Brahmananda Reddy, P. Muraray Govind, R. Pratheema, J. Devachandran

          Apollo Speciality Hospital - OMR, Chennai, India

          P074 - Prevalence, risk factors and outcomes of methicillin-resistant staphylococcus aureus nasal colonization in critically ill patients

          H. Al-Dorzi, M. Almutairi, B. Alhamadi, A. Crizaldo Toledo, R. Khan, B. Al Raiy, Y. Arabi

          P075 - Multidrug-resistant Acinetobacter baumannii infection in intensive care unit patients in a hospital with building construction: Is there an association?

          H. Talaie

          P076 - Multidrug-resistant organisms in a Dutch ICU

          J. A. Van Oers, A. Harts, E. Nieuwkoop, P. Vos

          P077 - Epidemiology and risk factors of ICU acquired infections caused by multidrug-resistant gram negative bacilli

          Y. Boussarsar, F. Boutouta, S. Kamoun, I. Mezghani, S. Koubaji, A. Ben Souissi, A. Riahi, M. S. Mebazaa

          P078 - Improving outcomes of severe infections by multidrug-resistant pathogens with polyclonal IgM-enriched immunoglobulins

          E. Giamarellos-Bourboulis, N. Tziolos, C. Routsi, C. Katsenos, I. Tsangaris, I. Pneumatikos, G. Vlachogiannis, V. Theodorou, A. Prekates, E. Antypa, V. Koulouras, N. Kapravelos, C. Gogos, E. Antoniadou, K. Mandragos, A. Armaganidis

          P079 - Must change the medical practice in ICU?

          A. R. Robles Caballero, B. Civantos, J. C. Figueira, J. López

          P080 - Mediterranean spotted fever in an infectious diseases intensive care unit

          A. Silva-Pinto, F. Ceia, A. Sarmento, L. Santos

          P081 - Clinical features and outcomes of patients with Middle East respiratory syndrome requiring admission to a saudi intensive care unit: A retrospective analysis of 31 cases

          G. Almekhlafi, Y. Sakr

          P082 - The ICU response to a hospital outbreak of Middle East respiratory syndrome coronavirus infection

          H. Al-Dorzi, R. Khan, S. Baharoon, A. Aldawood, A. Matroud, J. Alchin, S. Al Johani, H. Balkhy, Y. Arabi

          P083 - Middle East respiratory syndrome: Surveillance data analysis

          S. Alsolamy, S. Y. Yousif, B. O. Alotabi, A. S. Alsaawi

          P085 - Use of Taqman array card molecular diagnostics in severe pneumonia: A case series

          J. Ang, MD Curran, D. Enoch, V. Navapurkar, A. Conway Morris

          P086 - ‘BUNS’: An investigation protocol improves the ICU management of pneumonia

          R. Sharvill, J. Astin

          P087 - Pneumonia in patients following secondary peritonitis: epidemiological features and impact on mortality

          M. Heredia-Rodríguez, E. Gómez-Sánchez, M. T. Peláez-Jareño, E. Gómez-Pesquera, M. Lorenzo-López, P. Liu-Zhu, M. Aragón-Camino, A. Hernández-Lozano, A. Sánchez-López, E. Álvarez-Fuente, E. Tamayo

          P088 - The use of the “CURB-65 score” by emergency room clinicians in a large teaching hospital

          J. Patel, C. Kruger

          P089 - Incidence of community acquired pneumonia with viral infection in mechanically ventilated patients in the medical intensive care unit

          J. O’Neal, H. Rhodes, J. Jancik

          P090 - The SAATELLITE Study: Prevention of S aureus Nosocomial Pneumonia (NP) with MEDI4893, a Human Monoclonal Antibody (mAb) Against S aureus

          B. François, P. F. Laterre, P. Eggimann, A. Torres, M. Sánchez, P. F. Dequin, G. L. Bassi, J. Chastre, H. S. Jafri

          P091 - Risk factors and microbiological profile for nosocomial infections in trauma patients

          M. Ben Romdhane, Z. Douira, S. Kamoun, M. Bousselmi, A. Ben Souissi, Y. Boussarsar, A. Riahi, M.S. Mebazaa

          P092 - Correlation between percentages of ventilated patients developed vap and use of antimicrobial agents in ICU patients.

          A. Vakalos, V. Avramidis

          P093 - A comparison of two ventilator associated pneumonia surveillance techniques

          T. H. Craven, G. Wojcik, K. Kefala, J. McCoubrey, J. Reilly, R. Paterson, D. Inverarity, I. Laurenson, T. S. Walsh

          P094 - Lung ultrasound before and after fiberbronchoscopy - modifications may improve ventilator-associated pneumonia diagnosis

          S. Mongodi, B. Bouhemad, A. Orlando, A. Stella, G. Via, G. Iotti, A. Braschi, F. Mojoli

          P095 - Comparing the accuracy of predictors of mortality in ventilator-associated pneumonia

          M. Haliloglu, B. Bilgili, U. Kasapoglu, I. Sayan, M. Süzer Aslan, A. Yalcın, I. Cinel

          P096 - Impact of pRBCs transfusion on percentage of ventilated patients developed VAP in ICU patients

          A. Vakalos, V. Avramidis

          P097 - The impact of a series of interventions on the rate of ventilator associated pneumonia in a large teaching hospital

          H. E. Ellis, K. Bauchmuller, D. Miller, A Temple

          P098 - The EVADE study: Prevention of Nosocomial Pneumonia (NP) caused by P aeruginosa with MEDI3902, a Novel Bispecific Monoclonal Antibody, against P aeruginosa virulence factors

          J. Chastre, B. François, A. Torres, C. E. Luyt, M. Sánchez, M. Singer, H. S. Jafri

          P099 - Short-term inhaled colistin adjunctive therapy for ventilator-associated pneumonia

          Y. Nassar, M. S. Ayad

          P100 - Effect of aerosolised colistin on weaning from mechanical ventilation

          A. Trifi, S. Abdellatif, F. Daly, R. Nasri, S. Ben Lakhal

          P101 - Septic shock is an independent risk factor for colistin-induced severe acute kidney injury: a retrospective cohort study

          B. Bilgili, M. Haliloglu, F. Gul, I. Cinel

          P102 - Nosocomial pneumonia - emphasis on inhaled tobramycin

          A. Kuzovlev, A. Shabanov, S. Polovnikov, V. Moroz

          P103 - In vitro evaluation of amikacin inhale and commercial nebulizers in a mechanical ventilator

          N. Kadrichu, T. Dang, K. Corkery, P. Challoner

          P104 - The effects of nebulized amikacin/fosfomycin and systemic meropenem on severe amikacin-resistant meropenem-susceptible P.aeruginosa pneumonia

          G. Li Bassi, E. Aguilera, C. Chiurazzi, C. Travierso, A. Motos, L. Fernandez, R. Amaro, T. Senussi, F. Idone, J. Bobi, M. Rigol, A. Torres

          P105 - Optimization of gentamicin peak concentrations in critically ill patients

          C. J. Hodiamont, N. P. Juffermans, J. M. Janssen, C. S. Bouman, R. A. Mathôt, M. D. De Jong, R. M. Van Hest

          P106 - Systematic review of cefepime induced neurotoxicity

          L. Payne, G. L. Fraser

          P107 - Unasyn® causes QT prolongation during treatment of intensive care patients

          B. Tudor, M. Lahner, G. Roth, C. Krenn

          P108 - Comparative study between teicoplanin and vancomycin in methicillin-resistant staphylococcus aureus (mrsa) infectious of toxicological intensive care unit (ticu) patients – Tehran, Iran

          H. Talaie

          P109 - Phage therapy against antimicrobial resistance, design of the first clinical study phagoburn

          P. Jault, J. Gabard, T. Leclerc, S. Jennes, Y. Que, A. Rousseau, F. Ravat

          P110 - Antibiotic dosing errors in critically ill patients with severe sepsis or septic shock

          H. Al-Dorzi, A. Eissa, S. Al-Harbi, T. Aldabbagh, R. Khan, Y. Arabi

          P111 - Does empiric antifungal therapy improve survival in septic critically ill patients? (immunocompromised excluded)

          A. Trifi, S. Abdellatif, F. Daly, R. Nasri, S. Ben Lakhal

          P112 - Neurocysticercosis-Qatar experience

          F. Paramba, N. Purayil, V. Naushad, O. Mohammad, V. Negi, P. Chandra

          P113 - Early indicators in acute haemorrhagic shock

          A. Kleinsasser

          P114 - Filtering of red blood cells reduces the inflammatory response of pulmonary cells in an in vitro model of mechanical ventilation

          M. R. Witrz, J. F. Buchner-Doeven, A. M. Tuip-de Boer, J. C. Goslings, N. P. Juffermans

          P115 - Microparticles from red blood cell transfusion induce a pro-coagulant and pro-inflammatory endothelial cell response

          M. Van Hezel, M. Straat, A Boing, R Van Bruggen, N Juffermans

          P116 - The contribution of cytokines on thrombosis development during hospitalization in ICU

          D. Markopoulou, K. Venetsanou, V. Kaldis, D. Koutete, D. Chroni, I. Alamanos

          P117 - Prophylactic enoxaparin dosing and adjustment through anti-xa monitoring in an inpatient burn unit

          L. Koch, J. Jancik, H. Rhodes, E. Walter

          P118 - Determination of optimal cut-off values of haemoglobin, platelet count and fibrinogen at 24 hours after injury associated with mortality in trauma patients

          K. Maekawa, M. Hayakawa, S. Kushimoto, A. Shiraishi, H. Kato, J. Sasaki, H. Ogura, T. Matauoka, T. Uejima, N. Morimura, H. Ishikura, A. Hagiwara, M. Takeda

          P119 - Trauma-induced coagulopathy - prothrombin complex concentrate vs fresh frozen plasma

          O. Tarabrin, S. Shcherbakow, D. Gavrychenko, G. Mazurenko, V. Ivanova, O. Chystikov

          P120 - First study to prove the superiority of prothrombin complex concentrates on mortality rate over fresh frozen plasma in patients with acute bleeding

          C. Plourde, J. Lessard, J. Chauny, R. Daoust

          P121 - Prothrombin complex concentrate vs fresh frozen plasma in obstetric massive bleeding

          S. Shcherbakow, O. Tarabrin, D. Gavrychenko, G. Mazurenko, O. Chystikov

          P122 - Impact of FFP transfusion on VAP in ICU patients

          A. Vakalos, V. Avramidis

          P123 - Preoperative platelet function test and the thrombin generation assay are predictive for blood loss after cardiac surgery

          L. Kropman, L. In het Panhuis, J. Konings, D. Huskens, E. Schurgers, M. Roest, B. De Laat, M. Lance

          P124 - Rotational thromboelastometry versus standard coagulation tests before surgical interventions

          M. Durila, P. Lukas, M. Astraverkhava, J. Jonas

          P125 - Correction of impaired clot quality and stability by fibrinogen and activated prothrombin complex concentrate in a model of severe thrombocytopenia

          I. Budnik, B. Shenkman

          P126 - Assessment of point-of-care prothrombin time analyzer as a monitor after cardiopulmonary bypass

          H. Hayami, Y. Koide, T. Goto

          P127 - Disseminated intravascular coagulation (dic) is underdiagnosed in critically ill patients: do we need d-dimer measurements?

          R. Iqbal, Y. Alhamdi, N. Venugopal, S. Abrams, C. Downey, C. H. Toh, I. D. Welters

          P128 - Validity of the age-adjusted d-dimer cutoff in patients with COPD

          B. Bombay, J. M. Chauny, R. D. Daoust, J. L. Lessard, M. M. Marquis, J. P. Paquet

          P129 - A scoping review of strategies for prevention and management of bleeding following paediatric cardiopulmonary bypass surgery

          K. Siemens, D. Sangaran, B. J. Hunt, A. Durward, A. Nyman, I. A. Murdoch, S. M. Tibby

          P130 - Nadir hemoglobulin during cardiopulmonary bypass: impact on postoperative morbidity and mortality

          F. Ampatzidou, D. Moisidou, E. Dalampini, M. Nastou, E. Vasilarou, V. Kalaizi, H. Chatzikostenoglou, G. Drossos

          P131 - Red blood cell transfusion do not influence the prognostic value of RDW in critically ill patients

          S. Spadaro, A. Fogagnolo, T. Fiore, A. Schiavi, V. Fontana, F. Taccone, C. Volta

          P132 - Reasons for admission in the paediatric intensive care unit and the need for blood and blood products transfusions

          E. Chochliourou, E. Volakli, A. Violaki, E. Samkinidou, G. Evlavis, V. Panagiotidou, M. Sdougka

          P133 - The implementation of a massive haemorrhage protocol (mhp) for the management of major trauma: a ten year, single-centre study

          R. Mothukuri, C. Battle, K. Guy, G. Mills, P. Evans

          P134 - An integrated major haemorrhage protocol for pre-hospital and retrieval medical teams

          J. Wijesuriya, S. Keogh

          P135 - The impact of transfusion thresholds on mortality and cardiovascular events in patients with cardiovascular disease (non-cardiac surgery): a systematic review and meta-analysis

          A. Docherty, R. O’Donnell, S. Brunskill, M. Trivella, C. Doree, L. Holst, M. Parker, M. Gregersen, J. Almeida, T. Walsh, S. Stanworth

          P136 - The relationship between poor pre-operative immune status and outcome from cardiac surgery is specific to the peri-operative antigenic threat

          S. Moravcova, J. Mansell, A. Rogers, R. A. Smith, C. Hamilton-Davies

          P137 - Impact of simple clinical practice guidelines for reducing post-operative atrial fibrillation after cardiac surgery.

          A. Omar, M. Allam, O. Bilala, A. Kindawi, H. Ewila

          P138 - Dexamethasone administration during cardiopulmonary bypass has no beneficial effects on elective postoperative cardiac surgery patients

          F. Ampatzidou, D. Moisidou, M. Nastou, E. Dalampini, A. Malamas, E. Vasilarou, G. Drossos

          P139 - Intra-aortic balloon counterpulsation in patients undergoing cardiac surgery (IABCS): preliminary results

          G. Ferreira, J. Caldas, J. Fukushima, E. A. Osawa, E. Arita, L. Camara, S. Zeferino, J. Jardim, F. Gaioto, L. Dallan, F. B. Jatene, R. Kalil Filho, .F Galas, L. A. Hajjar

          P140 - Effects of low-dose atrial natriuretic peptide infusion on cardiac surgery-associated acute kidney injury

          C. Mitaka, T. Ohnuma, T. Murayama, F. Kunimoto, M. Nagashima, T. Takei, M. Tomita

          P141 - Acute kidney injury influence on high sensitive troponin measurements after cardiac surgery

          A. Omar, K. Mahmoud, S. Hanoura, S. Sudarsanan, P. Sivadasan, H. Othamn, Y. Shouman, R. Singh, A. Al Khulaifi

          P142 - Complex evaluation of endothelial dysfunction markers for prognosis of outcomes in patients undergoing cardiac surgery

          I. Mandel, S. Mikheev, I. Suhodolo, V. Kiselev, Y. Svirko, Y. Podoksenov

          P143 - New-onset atrial fibrillation in intensive care: incidence, management and outcome

          S. A. Jenkins, R. Griffin

          P144 - One single spot measurement of the sublingual microcirculation during acute pulmonary hypertension in a pig model of shock

          M. S. Tovar Doncel, A. Lima, C. Aldecoa, C. Ince

          P145 - Assessment of levosimendan as a therapeutic option to recruit the microcirculation in cardiogenic shock – initial experience in cardiac ICU

          A. Taha, A. Shafie, M. Mostafa, N. Syed, H. Hon

          P146 - Terlipressin vs. norepinephrine in the Potential Multiorgan Donor(PMD)

          F. Righetti, E. Colombaroli, G. Castellano

          P147 - Echocardiography in the potential heart donor exposed to substitution hormonotherapy

          F. Righetti, E. Colombaroli

          P148 - Machine learning can reduce rate of monitor alarms

          M. Hravnak, L. C. Chen, A. D. Dubrawski, G. C. Clermont, M. R. Pinsky

          P149 - Peripherally inserted central catheters placed in the ICU

          S. Gonzalez, D. Macias, J. Acosta, P. Jimenez, A. Loza, A. Lesmes, F. Lucena, C. Leon

          P150 - Recordings of abnormal central venous pressure waveform morphology during an episode of pulmonary hypertension in a porcine shock model

          M. S. Tovar Doncel, C. Ince, C. Aldecoa, A. Lima

          P151 - Ultrasound guided central venous access technique among French intensivists

          M. Bastide, J. Richecoeur, E. Frenoy, C. Lemaire, B. Sauneuf, F. Tamion, S. Nseir, D. Du Cheyron, H. Dupont, J. Maizel

          P152 - Predictive ability of the Pv-aCO2 gap in patients with shock

          M. Shaban, R. Kolko, N. Salahuddin, M. Sharshir, M. AbuRageila, A. AlHussain

          P153 - Comparison of echocardiography and pulmonary artery catheter measurements of hemodynamic parameters in critical ill patients

          P. Mercado, J. Maizel, L. Kontar, D. Titeca, F. Brazier, A. Riviere, M. Joris, T. Soupison, B. De Cagny, M. Slama

          P154 - The volume clamp method for noninvasive cardiac output measurement in postoperative cardiothoracic surgery patients: a comparison with intermittent pulmonary artery thermodilution

          J. Wagner, A. Körner, M. Kubik, S. Kluge, D. Reuter, B. Saugel

          P155 - Hemodynamic monitoring in patients with septic shock (SS) – CPCCO (continuous pulse contour cardiac output) vs. TEE (transesophageal echocardiography)

          E. Colombaroli, F. Righetti, G. Castellano

          P156 - Cardiac output measurement with transthoracic echocardiography in critically ill patients: a pragmatic clinical study

          T. Tran, D. De Bels, A. Cudia, M. Strachinaru, P. Ghottignies, J. Devriendt, C. Pierrakos

          P157 - Left ventricular outflow tract velocity time integral correlates with stroke volume index in mechanically ventilated patients

          Ó. Martínez González, R. Blancas, J. Luján, D. Ballesteros, C. Martínez Díaz, A. Núñez, C. Martín Parra, B. López Matamala, M. Alonso Fernández, M. Chana

          P158 - Transpulmonary thermodilution (TPTD) derived from femoral vs. jugular central venous catheter: validation of a previously published correction formula and a proprietary correction formula for global end-diastolic volume index (GEDVI)

          W. Huber, M. Eckmann, F. Elkmann, A. Gruber, I. Klein, R. M. Schmid, T. Lahmer

          P160 - Dynamic arterial elastance calculated with lidcoplus monitor does not predict changes in arterial pressure after a fluid challenge in postsurgical patients

          D. Bastoni, H. Aya, L. Toscani, L. Pigozzi, A. Rhodes, M. Cecconi

          P159 - Venous return driving pressure and resistance in acute blood volume changes

          P. W. Moller, S. Sondergaard, S. M. Jakob, J. Takala, D. Berger

          P160 - Dynamic arterial elastance calculated with lidcoplus monitor does not predict changes in arterial pressure after a fluid challenge in postsurgical patients

          D. Bastoni, H. Aya, L. Toscani, L. Pigozzi, A. Rhodes, M. Cecconi

          P161 - Analysis of duration of post-operative goal-directed therapy protocol

          C. Ostrowska, H. Aya, A. Abbas, J. Mellinghoff, C. Ryan, D. Dawson, A. Rhodes, M. Cecconi

          P162 - Hemodynamic optimization – back to square one?

          M. Cronhjort, O. Wall, E. Nyberg, R. Zeng, C. Svensen, J. Mårtensson, E. Joelsson-Alm

          P163 - Effectiveness of fluid thoracic content measurement by bioimpedance guiding intravascular volume optimization in patients with septic shock

          M. Aguilar Arzapalo, L. Barradas, V. Lopez, M. Cetina

          P164 - A systematic review on the role of internal jugular vein ultrasound measurements in assessment of volume status in critical shock patients

          N. Parenti, C. Palazzi, L. A. Amidei, F. B. Borrelli, S. C. Campanale, F. T. Tagliazucchi, G. S. Sedoni, D. L. Lucchesi, E. C. Carella, A. L Luciani

          P165 - Importance of recognizing dehydration in medical Intensive Care Unit

          M. Mackovic, N. Maric, M. Bakula

          P166 - Effect of volume for a fluid challenge in septic patients

          H. Aya, A. Rhodes, R. M. Grounds, N. Fletcher, M. Cecconi

          P167 - Fluid bolus practices in a large Australian intensive care unit

          B. Avard, P. Zhang

          P168 - Liberal late fluid management is associated with longer ventilation duration and worst outcome in severe trauma patients: a retrospective cohort of 294 patients

          M. Mezidi, J. Charbit, M. Ould-Chikh, P. Deras, C. Maury, O. Martinez, X. Capdevila

          P169 - Association of fluids and outcomes in emergency department patients hospitalized with community-acquired pneumonia

          P. Hou, W. Z. Linde-Zwirble, I. D. Douglas, N. S. Shapiro

          P170 - Association of positive fluid balance with poor outcome in medicosurgical ICU patients

          A. Ben Souissi, I. Mezghani, Y. Ben Aicha, S. Kamoun, B. Laribi, B. Jeribi, A. Riahi, M. S. Mebazaa

          P171 - Impact of fluid balance to organ dysfunction in critically ill patients

          C. Pereira, R. Marinho, R. Antunes, A. Marinho

          P172 - Volume bolus in ICU patients: do we need to balance our crystalloids?

          M. Crivits, M. Raes, J. Decruyenaere, E. Hoste

          P173 - The use of 6 % HES solution do not reduce total fluid requirement in the therapy of patients with burn shock

          V. Bagin, V. Rudnov, A. Savitsky, M. Astafyeva, I. Korobko, V. Vein

          P174 - Electron microscopic assessment of acute kidney injury in septic sheep resuscitated with crystalloids or different colloids

          T. Kampmeier , P. Arnemann, M. Hessler, A. Wald, K. Bockbreder, A. Morelli, H. Van Aken, S. Rehberg, C. Ertmer

          P175 - Alterations of conjunctival microcirculation in a sheep model of haemorrhagic shock and resuscitation with 0.9 % saline or balanced tetrastarch

          P. Arnemann, M. Hessler, T. Kampmeier, S. Rehberg, H. Van Aken, C. Ince, C. Ertmer

          P176 - A single centre nested pilot study investigating the effect of using 0.9 % saline or Plasma-Lyte 148 ® as crystalloid fluid therapy on gastrointestinal feeding intolerance in mechanically ventilated patients receiving nasogastric enteral nutrition

          S. Reddy, M. Bailey, R. Beasley, R. Bellomo, D. Mackle, A. Psirides, P. Young

          P177 - A single centre nested pilot study investigating the effect on post-operative bleeding of using 0.9 % saline or Plasma-Lyte® 148 as crystalloid fluid therapy in adults in ICU after heart surgery

          S. Reddy, M. Bailey, R. Beasley, R. Bellomo, D. Mackle, P. Young

          P178 - Extreme hypernatremia and sepsis in a patient with Huntington’s dementia: a conundrum in fluid management

          H. Venkatesh, S. Ramachandran, A. Basu, H. Nair

          P179 - Diagnosis and management of severe hypernatraemia in the critical care setting

          S. Egan, J. Bates

          P180 - Correlation between arterial blood gas and electrolyte disturbances during hospitalization and outcome in critically ill patients

          S. Oliveira, N. R. Rangel Neto, F. Q. Reis

          P181 - Missing the “I” in MUDPILES – a rare cause of high anion gap metabolic acidosis (HAGMA)

          C. P. Lee, X. L. Lin, C. Choong , K. M. Eu, W. Y. Sim , K. S. Tee, J. Pau , J. Abisheganaden

          P182 - Plasma NGAL and urinary output: potential parameters for early initiation of renal replacement therapy

          K. Maas, H. De Geus

          P183 - Renal replacement therapy for critically ill patients: an intermittent continuity

          E. Lafuente, R. Marinho, J. Moura, R. Antunes, A. Marinho

          P184 - A survey of practices related to renal replacement therapy in critically ill patients in the north of England.

          T. E. Doris, D. Monkhouse, T. Shipley, S. Kardasz, I Gonzalez

          P185 - High initiation creatinine associated with lower 28-day mortality in critically ill patients necessitating continuous renal replacement therapy

          S. Stads, A. J. Groeneveld

          P186 - The impact of Karnofsky performance scale on outcomes in acute kidney injury patients receiving renal replacement therapy on the intensive care unit

          I. Elsayed, N. Ward, A. Tridente, A. Raithatha

          P187 - Severe hypophosphatemia during citrate-anticoagulated CRRT

          A. Steuber, C. Pelletier, S. Schroeder, E. Michael, T. Slowinski, D. Kindgen-Milles

          P188 - Citrate regional anticoagulation for post dilution continuous renal replacement therapy

          S. Ghabina

          P189 - Citrate 18 mmol/l improves anticoagulation during RRT with adsorbing filters

          F. Turani, A. Belli, S. Busatti, G. Barettin, F. Candidi, F. Gargano, R. Barchetta, M. Falco

          P190 - Calcium gluconate instead of calcium chloride in citrate-anticoagulated CVVHD

          O. Demirkiran, M. Kosuk, S. Bozbay

          P191 - Enhanced clearance of interleukin-6 with continuous veno-venous haemodialysis (CVVHD) using Ultraflux EMiC2 vs. Ultraflux AV1000S

          V. Weber, J. Hartmann, S. Harm, I. Linsberger, T. Eichhorn, G. Valicek, G. Miestinger, C. Hoermann

          P192 - Removal of bilirubin with a new adsorbent system: in vitro kinetics

          S. Faenza, D. Ricci, E. Mancini, C. Gemelli, A. Cuoghi, S. Magnani, M. Atti

          P193 - Case series of patients with severe sepsis and septic shock treated with a new extracorporeal sorbent

          T. Laddomada, A. Doronzio, B. Balicco

          P194 - In vitro adsorption of a broad spectrum of inflammatory mediators with CytoSorb® hemoadsorbent polymer beads

          M. C. Gruda, P. O’Sullivan, V. P. Dan, T. Guliashvili, A. Scheirer, T. D. Golobish, V. J. Capponi, P. P. Chan

          P195 - Observations in early vs. late use of cytosorb therapy in critically ill patients

          K. Kogelmann, M. Drüner, D. Jarczak

          P196 - Oxiris membrane decreases endotoxin during rrt in septic patients with basal EAA > 0,6

          F. Turani, A. B. Belli, S. M. Martni, V. C. Cotticelli, F. Mounajergi, R. Barchetta

          P197 - An observational prospective study on the onset of augmented renal clearance: the first report

          S. Morimoto, H. Ishikura

          P198 - An ultrasound- guided algorithm for the management of oliguria in severe sepsis

          I. Hussain, N. Salahuddin, A. Nadeem, K. Ghorab, K. Maghrabi

          P199 - Ultrasound in acute kidney injury (aki). First findings of farius, an education-programme in structural ultrasonography

          S. K. Kloesel, C. Goldfuss, A. Stieglitz, A. S. Stieglitz, L. Krstevska, G. Albuszies

          P200 - Effectiveness of renal angina index score predicting acute kidney injury on critically ill patients

          M. Aguilar Arzapalo, L. Barradas, V. Lopez, A. Escalante, G. Jimmy, M. Cetina

          P201 - Time length below blood pressure thresholds and progression of acute kidney injury in critically ill patients with or without sepsis: a retrospective, exploratory cohort study

          J. Izawa, T. Iwami, S. Uchino, M. Takinami, T. Kitamura, T. Kawamura

          P202 - Anaemia does not affect renal recovery in acute kidney injury

          J. G. Powell-Tuck, S. Crichton, M. Raimundo, L. Camporota, D. Wyncoll, M. Ostermann

          P203 - Estimated glomerular filtration rate based on serum creatinine: actual practice in Dutch ICU’s

          A. Hana, H. R. De Geus

          P204 - Comparison of estimated glomerular filtration rate calculated by mdrd, ckd-epi-serum-creatinine and ckd-epi-cystatin-c in adult critically ill patients

          H. R. De Geus, A. Hana

          P205 - Early diagnosis of septic acute kidney injury in medical critical care patients with a urine cell cycle arrest marker: insulin like growth factor binding protein-7 (IGFBP-7)

          M. Aydogdu, N. Boyaci, S. Yuksel, G. Gursel, A. B. Cayci Sivri

          P206 - Urinary neutrophil gelatinase-associated lipocalin as early biomarker of severe acute kidney injury in intensive care

          J. Meza-Márquez, J. Nava-López, R. Carrillo-Esper

          P207 - Shrunken pore syndrome is associated with a sharp rise in mortality in patients undergoing elective coronary artery bypass grafting

          A. Dardashti, A. Grubb

          P208 - The biomarker nephrocheck™ can discriminate the septic shock patients with an akin 1 or 2 acute renal failure who will not progress toward the akin 3 level

          J. Maizel, M. Wetzstein, D. Titeca, L. Kontar, F. Brazier, B. De Cagny, A. Riviere, T. Soupison, M. Joris, M. Slama

          P209 - A worldwide multicentre evaluation of acute kidney injury in septic and non-septic critically ill patients: the intensive care over nations (icon) audit

          E. Peters, H. Njimi, P. Pickkers, J. L. Vincent

          P210 - Does enhanced recovery after surgery reduce the incidence of acute kidney injury in those undergoing major gynae-oncological surgery?

          M. Waraich , J. Doyle, T. Samuels, L. Forni

          P211 - Identification of risk factors for the development of acute kidney injury after lower limb arthroplasty

          N. Desai, R. Baumber, P. Gunning, A. Sell

          P212 - Incidences and associations of acute kidney injury after major trauma

          S. Lin, H. Torrence, M. O’Dwyer, C. Kirwan, J. Prowle

          P213 - Acute kidney injury of major trauma patients

          T Kim

          P214 - Trajectory of serum creatinine after major surgery and the diagnosis of acute kidney injury

          M. E. O’Connor, R. W. Hewson, C. J. Kirwan, R. M. Pearse, J. Prowle

          P215 - Epidemiology of acute kidney injury after cardiac surgery. A single center retrospective study

          S. Hanoura , A. Omar, H. Othamn, S. Sudarsanan , M. Allam, M. Maksoud, R. Singh, A. Al Khulaifi

          P216 - Post-operative acute kidney injury after major non-cardiac surgery and its association with death in the following year

          M. E. O’Connor, R. W. Hewson, C. J. Kirwan, R. M. Pearse, J. Prowle

          P217 - Factors affecting acute renal failure in intensive care unit and effect of these factors on mortality

          O. Uzundere, D. Memis , M. Ýnal, A. , N. Turan

          P218 - Results of the live kidney transplantations according to national data of turkish organ and tissue information system

          M. A. Aydin, H. Basar, I. Sencan, A. Kapuagasi, M. Ozturk, Z. Uzundurukan, D. Gokmen, A. Ozcan, C. Kaymak

          P219 - Anaesthesia procedure and intensive therapy in patients with neck phlegmon

          V. A. Artemenko, A. Budnyuk

          P220 - Nasal high flow oygen for acute respiratory failure: a systematic review

          R. Pugh , S. Bhandari

          P221 - Setting optimal flow rate during high flow nasal cannula support: preliminary results

          T. Mauri, C. Turrini, T. Langer, P. Taccone, C. A. Volta, C. Marenghi, L. Gattinoni, A. Pesenti

          P222 - Dose to dose consistency across two different gas flow rates using cystic fibrosis and normal adult breathing profiles during nasal high flow oxygen therapy

          L. Sweeney, A . O’ Sullivan, P. Kelly, E. Mukeria, R. MacLoughlin

          P223 - Final results of an evaluation of airway medix closed suction system compared to a standard closed suction system

          M. Pfeffer, J. T. Thomas, G. B. Bregman, G. K. Karp, E. K. Kishinevsky, D. S. Stavi, N. A. Adi

          P224 - Different cuff materials and different leak tests - one size does not fit all

          T. Poropat, R. Knafelj

          P225 - Observational study on the value of the cuff-leak test and the onset of upper airway obstruction after extubation

          E. Llopart, M. Batlle, C. De Haro, J. Mesquida, A. Artigas

          P226 - A device for emergency transtracheal lung ventilation

          D. Pavlovic, L. Lewerentz, A. Spassov, R. Schneider

          P227 - Long-term outcome and health-related quality of life in patients discharged from the intensive care unit with a tracheostomy and with or without prolonged mechanical ventilation

          S. De Smet, S. De Raedt, E. Derom, P Depuydt, S. Oeyen, D. Benoit, J. Decruyenaere

          P228 - Ultrasound-guided percutaneous dilational tracheostomy versus bronchoscopy-guided percutaneous dilational tracheostomy in critically ill patients (trachus): a randomized clinical trial

          A. Gobatto, B. Bese, P. Tierno, L. Melro, P. Mendes, F. Cadamuro, M. Park, L. M. Malbouisson

          P229 - Is it safe to discharge patients with tracheostomy from the ICU to the ward?

          B. C. Civanto, J. L. Lopez, A. Robles, J. Figueira, S. Yus, A. Garcia

          P230 - The application of tracheostomy in children in ICU

          A. Oglinda, G. Ciobanu, C. Oglinda, L. Schirca, T. Sertinean, V. Lupu

          P231 - The impact of passive humidifiers on aerosol drug delivery during mechanical ventilation

          P. Kelly, A. O’Sullivan, L. Sweeney, R. MacLoughlin

          P232 - Evaluation of vibrating mesh and jet nebuliser performance at two different attachment setups in line with a humidifier nebuliser system

          A. O’Sullivan, P. Kelly, L. Sweeney, E. Mukeria, M. Wolny , R. MacLoughlin

          P233 - Psv-niv versus cpap in the treatment of acute cardiogenic pulmonary edema

          A. Pagano, F. Numis, G. Vison, L. Saldamarco, T. Russo, G. Porta, F. Paladino

          P234 - Noninvasive ventilation in patients with haematologic malignancy: a retrospective review

          C. Bell, J. Liu, J. Debacker, C. Lee, E. Tamberg, V. Campbell, S. Mehta

          P235 - Use of non-invasive ventilation in infectious diseases besides classical indications

          A. Silva-Pinto, A. Sarmento, L. Santos

          P236 - The impact of fragility on noninvasive mechanical ventilation application and results in the ICU

          Ý. Kara, F. Yýldýrým, A. Zerman, Z. Güllü, N. Boyacý, B. Basarýk Aydogan, Ü. Gaygýsýz, K. Gönderen, G. Arýk, M. Turkoglu, M. Aydogdu, G. Aygencel, Z. Ülger, G. Gursel

          P237 - Effects of metabolic alkalosis on noninvasive ventilation success and ICU outcome in patients with hypercapnic respiratory failure

          N. Boyacý, Z. Isýkdogan, Ö. Özdedeoglu, Z. Güllü, M. Badoglu, U. Gaygýsýz, M. Aydogdu, G. Gursel

          P238 - Asynchrony index and breathing patterns of acute exacerbation copd patients assisted with noninvasive pressure support ventilation and neurally adjusted ventilatory assist

          N. Kongpolprom, C. Sittipunt

          P239 - High frequency jet ventilation for severe acute hypoxemia

          A. Eden, Y. Kokhanovsky, S. Bursztein – De Myttenaere, R. Pizov

          P240 - HFOV revisited: a 7 year retrospective analysis of patients receiving HFOV who met oscillate trial entry criteria

          L. Neilans, N. MacIntyre

          P241 - Implementation of a goal-directed mechanical ventilation order set driven by respiratory therapists can improve compliance with best practices for mechanical ventilation

          M. Radosevich, B. Wanta, V. Weber, T. Meyer, N. Smischney, D. Brown, D. Diedrich

          P242 - A reduction in tidal volumes for ventilated patients on ICU calculated from IBW. can it minimise mortality in comparison to traditional strategies?

          A . Fuller, P. McLindon, K. Sim

          P243 - Predictive value of lung aeration scoring using lung ultrasound in weaning failure

          M. Shoaeir, K. Noeam, A. Mahrous, R. Matsa, A. Ali

          P244 - Conventional versus automated weaning from mechanical ventilation using SmartCare™

          C. Dridi, S. Koubaji, S. Kamoun, F. Haddad, A. Ben Souissi, B. Laribi, A. Riahi, M. S. Mebazaa

          P245 - Ultrasonographic evaluation protocol for weaning from mechanichal ventilation

          A. Pérez-Calatayud, R. Carrillo-Esper, A. Zepeda-Mendoza, M. Diaz-Carrillo, E. Arch-Tirado

          P246 - Diaphragm ultrasonography: a method for weaning patients from mechanical ventilation

          S. Carbognin, L. Pelacani, F. Zannoni, A. Agnoli, G. Gagliardi

          P247 - Dorsal diaphragmatic excursion tracks transpulmonary pressure in ventilated ARDS patients: a potential non-invasive indicator of lung recruitment?

          R. Cho, A. Adams , S. Lunos, S. Ambur, R. Shapiro, M. Prekker

          P248 - Pulse oximetry in the icu patient: is the perfusion index of any value?

          M. Thijssen, L. Janssen, N. Foudraine

          P249 - Ventilation is a better assessment of respiratory status than EtCO2

          C. J. Voscopoulos, J. Freeman

          P250 - Evaluation of the relationship between non-invasive minute ventilation and end-tidal CO2 in patients undergoing general vs spinal anesthesia

          C. J. Voscopoulos, J. Freeman, E. George

          P251 - Respiratory volume monitoring provides early warning of respiratory depression and can be used to reduce false alarms in non-intubated patients

          C. J. Voscopoulos, D. Eversole, J. Freeman, E. George

          P252 - P/i index: a predictive edi-derived weaning index during nava

          S. Muttini, R. Bigi, G. Villani, N. Patroniti

          P253 - Adequacy of ventilation in patients receiving opioids in the post anesthesia care unit: minute ventilation versus respiratory rate

          G. Williams, C. J. Voscopoulos, J. Freeman, E. George

          P254 - Comparison of regional and global expiratory time constants measured by electrical impedance tomography (EIT)

          A. Waldmann, S. Böhm, W. Windisch, S. Strassmann, C. Karagiannidis

          P255 - Electrical impedance tomography: robustness of a new pixel wise regional expiratory time constant calculation

          A. Waldmann, S. Böhm, W. Windisch, S. Strassmann, C. Karagiannidis

          P256 - Validation of regional and global expiratory time constant measurement by electrical impedance tomography in ards and obstructive pulmonary diseases

          C. K. Karagiannidis, A. W. Waldmann, S. B. Böhm, S. Strassmann, W. W. Windisch

          P257 - Transpulmonary pressure in a model with elastic recoiling lung and expanding chest wall

          P. Persson, S. Lundin, O. Stenqvist

          P258 - Lactate in pleural and abdominal effusion

          G. Porta, F. Numis, C. S. Serra, A. P. Pagano, M. M. Masarone, L. R. Rinaldi, A. A. Amelia, M. F. Fascione, L. A. Adinolfi, E. R. Ruggiero

          P259 - Outcome of patients admitted to the intensive care with pulmonary fibrosis

          F. Asota, K. O’Rourke, S. Ranjan, P. Morgan

          P260 - Sedation and analgesia practice in extra-corporeal membrane oxygenation (ECMO)-treated patients with acute respiratory distress syndrome (ARDS): a retrospective study

          J. W. DeBacker, E. Tamberg, L. O’Neill, L. Munshi, L. Burry, E. Fan, S. Mehta

          P261 - Characteristics and outcomes of patients deemed not eligible when referred for veno-venous extracorporeal membrane oxygenation (vv-ECMO)

          S. Poo, K. Mahendran, J. Fowles, C. Gerrard, A. Vuylsteke

          P262 - The SAVE SMR for veno-arterial ECMO

          R. Loveridge, C. Chaddock, S. Patel, V. Kakar, C. Willars, T. Hurst, C. Park, T. Best, A. Vercueil, G. Auzinger

          P263 - A simplified score to predict early (48 h) mortality in patients being considered for VA-ECMO

          A. Borgman, A. G. Proudfoot, E. Grins, K. E. Emiley, J. Schuitema, S. J. Fitch, G. Marco, J. Sturgill, M. G. Dickinson, M. Strueber, A. Khaghani, P. Wilton, S. M. Jovinge

          P264 - Lung function six months post extra corporeal membrane oxygenation (ECMO) for severe acute respiratory failure in adult survivors

          C. Sampson, S. Harris-Fox

          P265 - Bicarbonate dialysis removes carbon dioxide in hypoventilated rodents.

          M. E. Cove, L. H. Vu, A. Sen, W. J. Federspiel, J. A. Kellum

          P266 - Procalcitonin as predictor of primary graft dysfunction and mortality in post-lung transplantation

          C. Mazo Torre, J. Riera, S. Ramirez, B. Borgatta, L. Lagunes, J. Rello

          P267 - New molecular biomarkers of acute respiratory distress syndrome in abdominal sepsis

          A. K. Kuzovlev, V. Moroz, A. Goloubev, S. Polovnikov, S. Nenchuk

          P268 - Tight junction’s proteins claudin -5 and regulation by tnf in experimental murine lung injury model of ali/ards

          V. Karavana, C. Glynos, A. Asimakos, K. Pappas, C. Vrettou, M. Magkou, E. Ischaki, G. Stathopoulos, S. Zakynthinos

          P269 - Cell counts in endobronchial aspirate to assess airway inflammation in ARDS patients: a pilot study

          S. Spadaro, I. Kozhevnikova, F. Dalla Corte, S. Grasso, P. Casolari, G. Caramori, C. Volta

          P270 - Epidemiological and clinical profile of patients with acute respiratory distress syndrome in the surgical intensive care unit surgical, hospital JRA, Antananarivo

          T. Andrianjafiarinoa, T. Randriamandrato, T. Rajaonera

          P271 - Effect of high PEEP after recruitment maneuver on right ventricular function in ARDS. Is it good for the lung and for the heart?

          S. El-Dash, ELV Costa, MR Tucci, F Leleu, L Kontar, B. De Cagny, F. Brazier, D. Titeca, G. Bacari-Risal, J. Maizel, M. Amato, M. Slama

          P272 - Effect of recruitment maneuver on left ventricular systolic strain

          P. Mercado, J. Maizel, L. Kontar, D. Titeca, F. Brazier, A. Riviere, M. Joris, T. Soupison, B. De Cagny, S. El Dash, M. Slama

          P273 - Inhaled nitric oxide – is switching supplier cost effective?

          Remmington, A. Fischer, S. Squire, M. Boichat

          P274 - Epidemiological study of severe acute pancreatitis in Japan, comparison of the etiology and the patient outcomes on 1159 patients.

          H. Honzawa, H. Yasuda, T. Adati, S. Suzaki, M. Horibe, M. Sasaki, M. Sanui

          P275 - Extracorporeal liver support therapy. Experience in an intensive care unit

          R. Marinho, J. Daniel, H. Miranda, A. Marinho

          P276 - Accuracy of mortality prediction models in acute versus acute-on-chronic liver failure in the intensive care setting

          K. Milinis, M. Cooper, G. R. Williams, E. McCarron, S. Simants, I. Patanwala, I. Welters

          P277 - Risk of coronary artery disease in patients with chronic liver disease: a population based cohort study

          Y. Su

          P278 - 20 years of liver transplantation in Santiago de Compostela (Spain). Experience review

          J. Fernández Villanueva, R. Fernández Garda, A. López Lago, E. Rodríguez Ruíz, R. Hernández Vaquero, S. Tomé Martínez de Rituerto, E. Varo Pérez

          P279 - Diarrhea is a risk factor for liver injury and may lead to intestinal failure associated liver disease in critical illness

          N. Lefel, F. Schaap, D. Bergmans, S. Olde Damink, M. Van de Poll

          P280 - Bowel care on the intensive care unit: constipation guideline compliance and complications

          K. Tizard, C. Lister, L. Poole

          P281 - Malnutrition assessed by phase angle determines outcomes in low risk cardiac surgery patients

          D. Ringaitiene, D. Gineityte, V. Vicka, I. Norkiene, J. Sipylaite

          P282 - Preoperative fasting times in an irish hospital

          A. O’Loughlin, V. Maraj, J. Dowling

          P283 - Costs and final outcome of early x delayed feeding in a private Brazil ICU

          M. B. Velasco, D. M. Dalcomune, E. B. Dias, S. L. Fernandes

          P284 - Can ventilator derived energy expenditure measurements replace indirect calorimetry?

          T. Oshima, S. Graf, C. Heidegger, L. Genton, V. Karsegard, Y. Dupertuis, C. Pichard

          P285 - Revisiting the refeeding syndrome: results of a systematic review

          N. Friedli, Z. Stanga, B. Mueller, P. Schuetz

          P286 - Compliance with the new protocol for parenteral nutrition in our ICU

          L. Vandersteen, B. Stessel, S. Evers, A. Van Assche, L. Jamaer, J. Dubois

          P287 - Nutrition may be another treatment in the intensive care unit where less is more?

          R. Marinho, H. Castro, J. Moura, J. Valente, P. Martins, P. Casteloes, C. Magalhaes, S. Cabral, M. Santos, B. Oliveira, A. Salgueiro, A. Marinho

          P288 - Should we provide more protein to critically ill patients?

          R. Marinho, M. Santos, E. Lafuente, H. Castro, S. Cabral, J. Moura, P. Martins, B. Oliveira, A. Salgueiro, S. Duarte, S. Castro, M. Melo, P. Casteloes, A. Marinho

          P289 Protein provision in an adult intensive care unit

          S. Gray

          P290 - Prevalence and clinical outcomes of vitamin d deficiency in the medical critically ill patients in Songklanagarind hospital

          K. Maipang, R. Bhurayanontachai

          P291 - Vitamin d deficiency strongly predicts adverse medical outcome across different medical inpatient populations: results from a prospective study

          L. G. Grädel, P. Schütz

          P292 - Omega-3 fatty acids in patients undergoing cardiac surgery: a systematic review and meta-analysis

          P. Langlois, W. Manzanares

          P293 - Can 5-hydroxytriptophan prevent post-traumatic stress disorder in critically ill patients?

          R. Tincu, C. Cobilinschi, D. Tomescu, Z. Ghiorghiu, R. Macovei

          P294 - Parenteral selenium in the critically ill: an updated systematic review and meta-analysis

          W. Manzanares, P. Langlois, M. Lemieux, G. Elke, F. Bloos, K. Reinhart, D. Heyland

          P295 - Probiotics in the critically ill: an updated systematic review and meta-analysis

          P. Langlois, M. Lemieux, I. Aramendi, D. Heyland, W. Manzanares

          P296 - Diabetes with hyperglycemic crisis episodes may be associated with higher risk of pancreatic cancer: a population-based cohort study

          Y. Su

          P297 - Incidence of hypoglycemia in an intensive care unit depending on insulin protocol

          R. Marinho, N. Babo, A. Marinho

          P298 - Severity of the diseases is two-dimensionally correlated to blood glucose, including blood glucose variability, especially in moderately to severely ill patients with glucose intolerance.

          M. Hoshino, Y. Haraguchi, S. Kajiwara, T. Mitsuhashi, T. Tsubata, M. Aida

          P299 - A study of glycemic control by subcutaneous glargine injection transition from continuous regular insulin infusion in critically ill patients

          T. Rattanapraphat, R. Bhurayanontachai, C. Kongkamol, B. Khwannimit

          P300 - Glycemic control in Portuguese intensive care unit

          R. Marinho, M. Santos, H. Castro, E. Lafuente, A. Salgueiro, S. Cabral, P. Martins, J. Moura, B. Oliveira, M. Melo, B. Xavier, J. Valente, C. Magalhaes, P. Casteloes, A. Marinho

          P301 - Impact of hyperglycemia duration on the day of operation on short-term outcome of cardiac surgery patients

          D. Moisidou, F. Ampatzidou, C. Koutsogiannidis, M. Moschopoulou, G. Drossos

          P302 - Lactate levels in diabetic ketoacidosis patients at ICU admissions

          G. Taskin, M. Çakir, AK Güler, A. Taskin, N. Öcal, S. Özer, L. Yamanel

          P303 - Intensive care implications of merging heart attack centre units in London

          J. M. Wong, C. Fitton, S. Anwar, S. Stacey

          P304 - Special characteristics of in-hospital cardiac arrests

          M. Aggou, B. Fyntanidou, S. Patsatzakis, E. Oloktsidou, K. Lolakos, E. Papapostolou, V. Grosomanidis

          P305 - Clinical evaluation of ICU-admitted patients who were resuscitated in the general medicine ward

          S. Suda , T. Ikeda, S. Ono, T. Ueno, Y. Izutani

          P306 - Serious game evaluation of a one-hour training basic life support session for secondary school students: new tools for future bystanders

          S. Gaudry, V. Desailly, P. Pasquier, PB Brun, AT Tesnieres, JD Ricard, D. Dreyfuss, A. Mignon

          P307 - Public and clinical staff perceptions and knowledge of CPR compared to local and national data

          J. C White, A. Molokhia, A. Dean, A. Stilwell, G. Friedlaender

          P308 Dispatcher-assisted telephone cardiopulmonary resuscitation using a French-language compression-ventilation pediatric protocol

          M. Peters, S. Stipulante, A. Delfosse, AF Donneau, A. Ghuysen

          P309 Dantrolene versus amiodarone for resuscitation – an experimental study

          C. Feldmann, D. Freitag, W. Dersch, M. Irqsusi, D. Eschbach, T. Steinfeldt, H. Wulf, T. Wiesmann

          P310 Long term survival and functional neurological outcome in comatose survivors undergoing therapeutic hypothermia

          N. Kongpolprom, J. Cholkraisuwat

          P311 Impact of kidney disease on mortality and neurological outcome in out-of-hospital cardiac arrest: a prospective observational study

          S. Beitland , E. Nakstad, H. Stær-Jensen , T. Drægni , G. Andersen , D. Jacobsen , C. Brunborg, B. Waldum-Grevbo , K. Sunde

          P312 ICU dependency of patients admitted after primary percutaneous coronary intervention (PPCI) following out of the hospital cardiac arrest

          K. Hoyland, D. Pandit

          P313 Prognostic indicators and outcome prediction model for patients with return of spontaneous circulation from cardiopulmonary arrest: comprehensive registry of in-hospital intensive care on OHCA survival (critical) study in Osaka, Japan

          K. Hayakawa

          P314 Cerebral oxygen saturation during resuscitation in a porcine model of cardiac arrest

          E. Oloktsidou, K. Kotzampassi, B. Fyntanidou, S. Patsatzakis, L. Loukipoudi, E. Doumaki, V. Grosomanidis

          P315 Presumption of cardiopulmonary resuscitation for sustaining cerebral oxidation using regional cerebral saturation of oxygen: observational cohort study (press study)

          H. Yasuda

          P316 EEG reactivity in patients after cardiac arrest: a close look at stimuli

          MM Admiraal, M. Van Assen, MJ Van Putten, M. Tjepkema-Cloostermans, AF Van Rootselaar, J. Horn

          P317 Prognostic value of neuron-specific enolase after cardiac arrest

          F. Ragusa, A. Marudi , S. Baroni, A. Gaspari, E. Bertellini

          P318 Correlation between electroencephalographic findings and serum neuron specific enolase with outcome of post cardiac arrest patients

          A. Taha, T. Abdullah, S. Abdel Monem

          P319 Introduction of a targeted temperature management strategy following cardiac arrest in a district general hospital intensive care unit.

          S. Alcorn, S. McNeill, S. Russell

          P320 The evolution of cerebral oxygen saturation in post-cardiac arrest patients treated with therapeutic hypothermia

          W. Eertmans, C. Genbrugge, I. Meex, J. Dens, F. Jans, C. De Deyne

          P321 Prognostic factors and neurological outcomes of therapeutic hypothermia in comatose survivors from cardiac arrest: 8-year single center experience

          J. Cholkraisuwat, N. Kongpolprom

          P322 Adherence to targeted temperature management after out of hospital cardiac arrest

          B. Avard, R. Burns

          P323 Implementation of a therapeutic hypothermia protocol for comatose survivors of out-of-hospital cardiac arrest.

          A. Patarchi, T. Spina

          P324 Factors associated with ventilator weaning after targeted temperature management for cardiac arrest patients in japan

          H. Tanaka, N. Otani, S. Ode, S. Ishimatsu

          P325 Differential activation of c-fos in paraventricular nuclei of the hypothalamus and thalamus of the rat following myocardial infarction

          J. Cho, J. B. Moon, C. W. Park, T. G. Ohk, M. C. Shin, M. H. Won

          P326 Monitoring of cTroponin I in patients with acute ischemic stroke - predictor of inhospital mortality

          S. Dakova, Z. Ramsheva, K. Ramshev

          P327 Hyperthermic preconditioning severely accelerates neuronal damage in the gerbil ischemic hippocampal dentate gyrus via decreasing sods expressions

          J. Cho, J. B. Moon, C. W. Park, T. G. Ohk, M. C. Shin

          P328 Failure in neuroprotection of remote limb ischemic post conditioning in the hippocampus of a gerbil model of transient cerebral ischemia

          J. Cho, J. B. Moon, C. W. Park, T. G. Ohk, M. C. Shin

          P329 Brain death and admission diagnosis in neurologic intensive care unit, a correlation?

          A Marudi, S Baroni, A Gaspari, E Bertellini

          P330 Brain magnetic resonance imaging findings in patients with septic shock

          G. Orhun, E. Senturk, P. E. Ozcan, S. Sencer, C. Ulusoy, E. Tuzun, F . Esen

          P331 Benefits of L-carnitine in valproic acid induced encephalopathy

          R. Tincu, C. Cobilinschi, D. Tomescu, Z. Ghiorghiu, R. Macovei

          P332Automatic analysis of EEG reactivity in comatose patients

          M. Van Assen, M. M. Admiraal, M. J. Van Putten, M. Tjepkema-Cloostermans, A. F. Van Rootselaar, J. Horn

          P333 Usefulness of common ICU severity scoring systems in predicting outcome after spontaneous intracerebral hemorrhage

          M. Fallenius, M. B. Skrifvars, M. Reinikainen, S. Bendel, R. Raj

          P334 Evalution of patients with suspected subarachnoid haemorrhage and negative ct imaging

          M. Abu-Habsa, C. Hymers, A. Borowska, H. Sivadhas, S. Sahiba, S. Perkins

          P335 Timing of endovascular and surgical treatment for aneurysmal subarachnoid haemorrhage: early but not so fast.

          J. Rubio, J. A. Rubio, R. Sierra

          P336 Red blood cell transfusion in aneurysmal subarachnoid hemorrhage – the Sahara cohort study

          S. English, M. Chasse, A. Turgeon, F. Lauzier, D. Griesdale, A. Garland, D. Fergusson, R. Zarychanski, A. Tinmouth, C. Van Walraven, K. Montroy, J. Ziegler, R. Dupont Chouinard, R. Carignan, A. Dhaliwal, C. Lum, J. Sinclair, G. Pagliarello, L. McIntyre

          P337 - Aneurysmal subarachnoid hemorrhage and anemia: a canadian multi-centre retrospective cohort study

          S. English, M. Chasse, A. Turgeon, F. Lauzier, D. Griesdale, A. Garland, D. Fergusson, R. Zarychanski, A. Tinmouth, C. Van Walraven, K. Montroy, J. Ziegler, R. Dupont Chouinard, R. Carignan, A. Dhaliwal, C. Lum, J. Sinclair, G. Pagliarello, L. McIntyre

          P338 - Does the neutrophil-to-lymphocyte (NLR) ratio predict symptomatic vasospasm or delayed cerebral ischemia (DCI) after aneurysmal subarachnoid haemorrhage (SAH)?

          T. Groza, N. Moreau, D. Castanares-Zapatero, P. Hantson

          P339 - ICU-acquired infections in aneurysmal subarachnoid hemorrhage patients: impact on ICU and hospital length of stay

          M. Carbonara , F. Ortolano, T. Zoerle, S. Magnoni, S. Pifferi, V. Conte, N. Stocchetti

          P340 - Cerebral metabolic effects of normobaric hyperoxia during the acute phase of aneurysmal subarachnoid hemorrhage

          L. Carteron, T. Suys, C. Patet, H. Quintard, M. Oddo

          P341 - Postoperative care for elective craniotomy: where is best done?

          J. A. Rubio, J. Rubio, R. Sierra

          P342 - 5-year follow-up of patients after transplantation of organs from donors from neurocritical care

          V. Spatenkova, E. Pokorna, P. Suchomel

          P343 - Evaluation of levetiracetam pharmacokinetics after severe traumatic brain injury in neurocritical care patients at a level one trauma center

          N. Ebert, J. Jancik, H. Rhodes

          P344 - Model based time series cluster analysis to determine unique patient states in traumatic brain injury

          T. Bylinski, C. Hawthorne, M. Shaw, I. Piper, J. Kinsella

          P345 - Brain compartment monitoring capabilities from ICP to BI (bioimpedance) during HS (hypertonic saline) administration. State of art simulation outcome depending on brain swelling type

          A. K. Kink , I. R. Rätsep

          P346 - Transfusion of red blood cells in patients with traumatic brain injury admitted to Canadian trauma health centers: a multicenter cohort study

          A. Boutin, L. Moore, M. Chasse, R. Zarychanski, F. Lauzier, S. English, L. McIntyre, J. Lacroix, D. Griesdale, P. Lessard-Bonaventure, A. F. Turgeon

          P347 - Hemoglobin thresholds and red blood cell transfusions in adult patients with moderate or severe traumatic brain injury: a retrospective cohort study

          A. Boutin, L. Moore, R. Green, P. Lessard-Bonaventure, M. Erdogan, M. Butler, F. Lauzier, M. Chasse, S. English, L. McIntyre, R. Zarychanski, J. Lacroix, D. Griesdale, P. Desjardins, D. A. Fergusson, A. F. Turgeon

          P348 - Characteristics of patients with gunshot wounds to the head - an observational Brazilian study

          B. Goncalves, B. Vidal, C. Valdez, A. C. Rodrigues, L. Miguez, G. Moralez

          P349 - Base excess as predictor for ICU admission and the injury severity in blunt trauma patients

          T. Hong

          P350 - Enhancement of usual emergency department care with proadrenomedullin to improve outcome prediction - Results from the multi-national, prospective, observational TRIAGE study

          A. Kutz, P. Hausfater, D. Amin, T. Struja, S. Haubitz, A. Huber, B. Mueller, P. Schuetz

          P351 - Developing an innovative emergency medicine point-of-care simulation programme

          T. Brown, J. Collinson, C. Pritchett, T. Slade

          P352 - The InSim program: an in situ simulation program for junior trainees in intensive care

          M. Le Guen, S. Hellings, R. Ramsaran

          P353 - Impact of excessive and inappropriate troponin testing in the emergency setting how good are we

          A. Alsheikhly

          P354 - The development of time tracking monitor at emergency department

          T. Abe

          P355 - Role of focussed echocardiography in emergency assessment of syncope

          L. Kanapeckaite, M. Abu-Habsa, R. Bahl

          P356 - Insertion of an open-ended 14-gauge catheter through the chest wall causes a significant pneumothorax in a self-ventilating swine model

          M. Q Russell, K. J. Real, M. Abu-Habsa , R. M. Lyon, N. P. Oveland

          P357 - Ez-io® intraosseous access teaching in the workplace using a mobile ‘tea trolley’ training method

          J. Penketh, M. Mcdonald, F. Kelly

          P358 - Black widow envenomation in Saudi Arabia: a prospective observational case series

          M. Alfafi, S. Alsolamy, W. Almutairi, B. Alotaibi

          P359 - Mechanical ventilation in patients with overdose not yet intubated on icu admission

          A. E. Van den Berg, Y. Schriel, L. Dawson, I. A. Meynaar

          P360 - Central nervous system depressants poisoning and ventilator associated pneumonia: an underrated risk factor in toxicological intensive care unit

          H. Talaie

          P361 - Acute barium intoxication treated with hemodiafiltration

          D. Silva, S. Fernandes, J. Gouveia, J. Santos Silva

          P362 - Major trauma presenting to the emergency department. the spectrum of cycling injuries in Ireland

          J. Foley, A. Kaskovagheorgescu, D. Evoy, J. Cronin, J. Ryan

          P363 - Burns from French military operations: a 14-year retrospective observational analysis.

          M. Huck, C. Hoffmann, J. Renner, P. Laitselart, N. Donat, A. Cirodde, J. V. Schaal, Y. Masson, A. Nau, T. Leclerc

          P364 - A comparison of mortality scores in burns patients on the intensive care unit.

          O. Howarth, K. Davenport, P. Jeanrenaud, S. Raftery

          P365 - Clasification of pain and its treatment and an intensive care rehabiliation clinic

          P. MacTavish, H. Devine, J. McPeake, M. Daniel, J. Kinsella, T. Quasim

          P366 - Pain management adequacy in critical care areas ,the process and the barriers perceived by critical care nurses

          S. Alrabiee, A. Alrashid , S. Alsolamy

          P367 - Pain assessment in critically ill adult patients: validation of the Turkish version of the critical-care pain observation tool

          O. Gundogan, C. Bor, E. Akýn Korhan, K. Demirag , M. Uyar

          P368 - An audit of pain and sedation assessments in the intensive care unit: recommendations for clinical practice

          F. Frame, C. Ashton, L. Bergstrom Niska

          P369 - Impact of pharmaceutical care on treatment of pain and agitation in medical intensive care unit

          P. Dilokpattanamongkol, T. Suansanae, C. Suthisisang, S. Morakul, C. Karnjanarachata, V. Tangsujaritvijit

          P370 - Agitation in trauma ICU, prevention and outcome

          S. Mahmood, H. Al Thani, A. Almenyar

          P371 Correlation between percentages of ventilated patients developed vap and use of sedative agents in icu patients.

          A. Vakalos , V. Avramidis

          P372 - Improving recording of sedation events in the Emergency Department: The implementation of the SIVA International Taskforce adverse event reporting tool for procedural sedation

          R. Sharvill, J. Penketh

          P373 - Impact of sedative drug use on the length of mechanical ventilation

          S. E. Morton, Y. S. Chiew, C. Pretty, J. G. Chase, G. M. Shaw

          P374 - Co-administration of nitric oxide and sevoflurane using anaconda

          R. Knafelj, P. Kordis

          P375 - A retrospective study of the use of Dexmedetomidine in an oncological critical care setting

          S. Patel, V. Grover

          P376 - Dexmedetomidine and posttraumatic stress disorder incidence in alcohol withdrawal icu patients

          I. Kuchyn, K. Bielka

          P377 - Hemodynamic effects of dexmedetomidine in a porcine model of septic shock

          Z. Aidoni, V. Grosomanidis, K. Kotzampassi, G. Stavrou, B. Fyntanidou, S. Patsatzakis, C. Skourtis

          P378 - Ketamine for analgosedation in severe hypoxic respiratory failure

          S. D. Lee, K. Williams, I. D. Weltes

          P379 - Madness from the moon? lunar cycle and the incidence of delirium on the intensive care unit

          S. Berhane, C. Arrowsmith, C. Peters, S. Robert

          P380 - Impaired dynamic cerebral autoregulation after coronary artery bypass grafting and association with postoperative delirium

          J. Caldas, R. B. Panerai, T. G. Robinson, L. Camara, G. Ferreira, E. Borg-Seng-Shu, M. De Lima Oliveira, N. C. Mian, L. Santos, R. Nogueira, S. P. Zeferino, M. Jacobsen Teixeira, F. Galas, L. A. Hajjar

          P381 - Risk factors predicting prolonged intensive care unit length of stay after major elective surgery.

          P. Killeen, M. McPhail, W. Bernal, J. Maggs, J. Wendon, T. Hughes

          P382 - Systemic inflammatory response syndrome criteria and hospital mortality prediction in a brazilian cohort of critically ill patients

          L. U. Taniguchi, E. M. Siqueira, J. M. Vieira Jr, L. C. Azevedo

          P383 - Evaluating the efficacy of a risk predictor panel in identifying patients at elevated risk of morbidity following emergency admission

          A. N. Ahmad, M. Abu-Habsa, R. Bahl, E. Helme, S. Hadfield, R. Loveridge

          P384 - A retrospective comparison of outcomes for elective surgical patients admitted post-operatively to the critical care unit or general ward

          J. Shak, C. Senver, R. Howard-Griffin

          P385 - Effect of obesity on mortality in surgical critically ill patients.

          P. Wacharasint, P. Fuengfoo, N. Sukcharoen, R. Rangsin

          P386 - The national early warning score (news) reliably improves adverse clinical outcome prediction in community-acquired pneumonia - results from a 6 year follow-up

          D. Sbiti-Rohr, P. Schuetz

          P387 - Clinical usefulness of the charlson¡¯s weighted index of comorbidities _as prognostic factor in patients with prolonged acute mechanical ventilation

          H. Na, S. Song, S. Lee, E. Jeong, K. Lee

          P388 - Comparison of mortality prediction scoring systems in patients with cirrhosis admitted to general intensive care unit

          M. Cooper, K. Milinis, G. Williams, E. McCarron, S. Simants, I. Patanwala, I. D. Welters

          P389 - Impact of admission source and time of admission on outcome of pediatric intensive care patients: retrospective 15 years study

          E. Zoumpelouli, EA Volakli, V. Chrysohoidou, S. Georgiou, K. Charisopoulou, E. Kotzapanagiotou, V. Panagiotidou, K. Manavidou, Z. Stathi, M. Sdougka

          P390 - Heart rate variability and outcomes prediction in critical illness

          N. Salahuddin, B. AlGhamdi, Q. Marashly, K. Zaza, M. Sharshir, M. Khurshid, Z. Ali, M. Malgapo, M. Jamil, A. Shafquat, M. Shoukri, M. Hijazi

          P391 - The incidence and outcome of hyperlactatemia in the post anaesthesia care unit

          T. Abe, S. Uchino, M. Takinami

          P392 - Correlation between arterial blood gas disturbances and arterial lactate levels during hospitalization and outcome in critically septic patients

          N. R. Rangel Neto, S. Oliveira, F. Q. Reis, F. A. Rocha

          P393 - External validation of saps 3 and mpm iii scores in 48,816 patients from 72 brazilian icus

          G. Moralez, K. Ebecken, L. S. Rabello, M. F. Lima, R. Hatum, F. V. De Marco, A. Alves, J. E. Pinto, M. Godoy, P. E. Brasil, F. A. Bozza, J. I. Salluh, M. Soares

          P394 - The frailty penalty: pre-admission functional status confounds mortality prediction models in critically ill patients

          J. Krinsley, G. Kang

          P395 - ‘sooner rather than later”: how delayed discharge from critical care leads to increased out of hours discharges and subsequent increase in in-hospital mortality.

          J. Perry, H. Hines

          P396 - Identifying poor outcome patient groups in a resource-constrained critical care unit

          K. M. Wilkinson, C. Tordoff, B. Sloan, M. C. Bellamy

          P397 - Effects of icu weekend admission and discharge on mortality.

          E. Moreira, F. Verga, M. Barbato, G. Burghi

          P398 - Organizational factors, outcomes and resource use in 9,946 cancer patients admitted to 70 ICUs

          M Soares, U. V. Silva, L. C. Azevedo, A. P. Torelly, J. M. Kahn, D. C. Angus, M. F. Knibel, P. E. Brasil, F. A. Bozza, J. I. Salluh

          P399 - Evaluation of oncological critically ill patients, severity score and outcome compared to not oncological in a particular hospital cti.

          M. B. Velasco, D. M. Dalcomune

          P400 - Outcomes of patients admitted to a large uk critical care department with palliative oncological diagnoses

          R. Marshall, T. Gilpin, A. Tridente, A. Raithatha

          P401 - Predictors of mortality in febrile neutropenic patients with haematological malignancies admitted to an intensive care unit of a cancer center

          D. Mota, B. Loureiro, J. Dias, O. Afonso, F. Coelho, A. Martins, F. Faria

          P402 - Patients with hematologic malignancies requiring invasive mechanical ventilation: characteristics and predictors of mortality

          H. Al-Dorzi, H. Al Orainni , F. AlEid, H. Tlaygeh, A. Itani, A. Hejazi, Y. Arabi

          P403 - Patient-important outcomes in randomized controlled trials in critically ill patients: a systematic review

          S. Gaudry, J. Messika, J. D. Ricard, S. Guillo, B. Pasquet, E. Dubief, D. Dreyfuss, F. Tubach

          P404 - Alopecia in survivors of critical illness: a qualitative study

          C . Battle, K. James, P. Temblett

          P405 - The impact of mental health on icu admission

          L. Davies, C. Battle, C. Lynch

          P406 - Cognitive impairment 5 years after ICU discharge

          S. Pereira, S. Cavaco, J. Fernandes, I. Moreira, E. Almeida, F. Seabra Pereira, M. Malheiro, F. Cardoso, I. Aragão, T. Cardoso

          P407 - Apache ii versus apache iv for octagenerians in medical icu

          M. Fister, R. Knafelj

          P408 - Outcomes of octagenarians in an indian icu

          P. Muraray Govind, N. Brahmananda Reddy, R. Pratheema, E. D. Arul, J. Devachandran

          P409 - Mortality and outcomes in elderly patients 80 years of age or older admitted to the icu

          M. B. Velasco , D. M. Dalcomune

          P410 - Octagenerians in medical icu - adding days to life or life to days?

          R. Knafelj, M. Fister

          P411 - The very elderly admitted to intensive care unit: outcomes and economic evaluation

          N. Chin-Yee, G. D’Egidio, K. Thavorn, D. Heyland, K. Kyeremanteng

          P412 - The very elderly in intensive care: relationship between acuity of illness and long-term mortality

          A. G. Murchison, K. Swalwell, J. Mandeville, D. Stott

          P413 - Acquired weakness in an oncological intensive care unit

          I. Guerreiro

          P414 - Musculoskeletal problems in intensive care unit (ICU) patients post-discharge

          H. Devine, P. MacTavish, J. McPeake, T. Quasim, J. Kinsella, M. Daniel

          P415 - Premorbid obesity, but not nutrition, prevents critical illness-induced muscle wasting and weakness

          C. Goossens M. B. Marques, S. Derde, S. Vander Perre, T. Dufour, S. E. Thiessen, F. Güiza, T. Janssens, G. Hermans, I. Vanhorebeek, K. De Bock, G. Van den Berghe, L. Langouche

          P416 - Physical outcome measures for critical care patients following intensive care unit (icu) discharge

          H. Devine, P. MacTavish, T. Quasim, J. Kinsella, M. Daniel, J. McPeake

          P417 - Improving active mobilisation in a general intensive care unit

          B. Miles , S. Madden, H. Devine

          P418 - Mobilization in patients on vasoactive drugs use – a pilot study.

          M. Weiler, P. Marques, C. Rodrigues, M. Boeira, K. Brenner, C. Leães, A. Machado, R. Townsend, J. Andrade

          P419 - Pharmacy intervention at an intensive care rehabilitation clinic

          P. MacTavish, J. McPeake, H. Devine, J. Kinsella, M. Daniel, R. Kishore, C. Fenlon, T. Quasim

          P420 - Interactive gaming is feasible and potentially increases icu patients’ motivation to be engaged in rehabilitation programs

          T. Fiks, A. Ruijter, M. Te Raa, P. Spronk

          P421 - Simulation-based design of a robust stopping rule to ensure patient safety

          Y. S. Chiew, P. Docherty, J. Dickson, E. Moltchanova, C. Scarrot, C. Pretty, G. M. Shaw, J. G. Chase

          P422 - Are daily blood tests on the intensive care unit necessary?

          T. Hall, W. C. Ngu, J. M. Jack, P. Morgan

          P423 - Measuring urine output in ward patients: is it helpful?

          B. Avard, A. Pavli, X. Gee

          P424 - The incidence of pressure ulcers in an adult mixed intensive care unit in turkey

          C . Bor, E. Akin Korhan, K. Demirag, M. Uyar

          P425 - Intensivist/patient ratios in closed ICUs in Alexandria, Egypt; an overview

          M. Shirazy, A. Fayed

          P426 - Eicu (electronic intensive care unit): impact on ALOS (average length of stay) in a developing country like India

          S. Gupta, A. Kaushal, S. Dewan, A. Varma

          P427 - Predicting deterioration in general ward using early deterioration indicator

          E. Ghosh, L. Yang, L. Eshelman, B. Lord, E. Carlson

          P428 - High impact enhanced critical care outreach - the imobile service: making a difference

          E. Helme, R. Broderick, S. Hadfield, R. Loveridge

          P429 - Impact of bed availability and cognitive load on intensive care unit (ICU) bed allocation: a vignette-based trial

          J. Ramos, D. Forte

          P430 - Characteristics of critically ill patients admitted through the emergency department

          F. Yang, P. Hou

          P431 - Admission to critical care: the quantification of functional reserve

          J. Dudziak, J. Feeney, K. Wilkinson, K. Bauchmuller, K. Shuker, M. Faulds, A. Raithatha, D. Bryden, L. England, N. Bolton, A. Tridente

          P432 - Admission to critical care: the importance of frailty

          K. Bauchmuller, K Shuker, A Tridente, M Faulds, A Matheson, J. Gaynor, D Bryden, S South Yorkshire Hospitals Research Collaboration

          P433 - Development of an instrument to aid triage decisions for intensive care unit admission

          J. Ramos, B. Peroni, R. Daglius-Dias, L. Miranda, C. Cohen, C. Carvalho, I . Velasco, D. Forte

          P434 - Using selective serotonin re-uptake inhibitors and serotonin-norepinephrine re-uptake inhibitors in critical care: a systematic review of the evidence for benefit or harm

          J. M. Kelly, A. Neill, G. Rubenfeld, N. Masson, A. Min

          P435 - Measuring adaptive coping of hospitalized patients with a severe medical condition:the sickness insight in coping questionnaire (sicq)

          E. Boezeman, J. Hofhuis , A. Hovingh, R. De Vries, P. Spronk

          P436 - Results of a national survey regarding intensive care medicine training

          G. Cabral-Campello, I. Aragão, T. Cardoso

          P437 - Work engagement among healthcare professionals in the intensive care unit

          M. Van Mol, M. Nijkamp, E . Kompanje

          P438 - Empowering the intensive care practitioners. is it a burnout ameliorating intervention?

          P. Ostrowski, A. Omar

          P439 - Icu patients suffer from circadian rhythm desynchronisation

          K. Kiss , B. Köves, V. Csernus, Z. Molnár

          P440 - Noise reduction in the ICU: feasible ?

          Y. Hoydonckx, S. Vanwing, B. Stessel, A. Van Assche, L. Jamaer, J. Dubois

          P441 - Accidental removal of invasive devices in the critical patient into the bed-washing. does the presence of professional nurse modify his incidence?

          V. Medo, R. Galvez, J. P. Miranda

          P442 - Deprivation of liberty safeguards (dols): audit of compliance in a of a 16-bed specialist cancer critical care unit.

          C. Stone, T. Wigmore

          P443 - Use of a modified cristal score to predict futility of critical care in the elderly

          Y. Arunan, A. Wheeler, K. Bauchmuller, D. Bryden

          P444 - Improvement of Referral Rate to Palliative Care for Patients with Poor Prognosis in Neurosurgical Intensive Care Unit

          Y. Wong, C. Poi, C. Gu

          P445 - Factors associated with limitation of life supporting care (lsc) in a medico-surgical intermediate care unit, and outcome of patients with lsc limitation: a monocentric, six-month study.

          P. Molmy, N. Van Grunderbeeck, O. Nigeon, M. Lemyze, D. Thevenin, J. Mallat

          P446 - Palliative care consultation and intensive care unit admission request: a cohort study

          J. Ramos, M. Correa, R. T. Carvalho, D. Forte

          P447 - Nursing and medicine together in postsurgical intensive care unit: situations of prognostic conflict at the end of life. our critical care nurses suffer with our medical activism?

          A. Fernandez, C. McBride

          P448 - End of life who may decide

          E. Koonthalloor, C. Walsh

          P449 - Correctly diagnosing death

          A. Webber, M. Ashe, K. Smith, P. Jeanrenaud

          P450 - Skin procurement performed by intensive care physicians: yes, we can.

          A. Marudi , S. Baroni, F. Ragusa, E. Bertellini

          P451 - Death analysis in pediatric intensive care patients

          E. A. Volakli , E. Chochliourou, M. Dimitriadou, A. Violaki, P. Mantzafleri, E. Samkinidou, O. Vrani, A. Arbouti, T. Varsami, M. Sdougka

          P452 - The potential impact of euthanasia on organ donation: analysis of data from belgium

          J. A. Bollen, T. C. Van Smaalen, W. C. De Jongh, M. M. Ten Hoopen, D. Ysebaert, L. W. Van Heurn, W. N. Van Mook

          P453 - Communication within an intensive care setting

          K. Sim, A. Fuller

          P454 - Development and implementation of a longitudinal communication curriculum for critical care medicine fellows

          A. Roze des Ordons, P. Couillard, C. Doig

          P455 - Staff-family conflict in a multi-ethnic intensive care unit

          R. V. Van Keer, R. D. Deschepper, A. F. Francke, L. H. Huyghens, J. B. Bilsen

          P456 - Does the source of admission to critical care affect family satisfaction?

          B. Nyamaizi, C. Dalrymple, A. Molokhia, A. Dobru

          P457 - A simple alternative to the family satisfaction survey (fs-icu)

          E. Marrinan, A. Ankuli, A. Molokhia

          P458 - A study to explore the experiences of patient and family volunteers in a critical care environment: a phenomenological analysis

          J. McPeake, R. Struthers, R. Crawford , H. Devine , P. Mactavish , T. Quasim

          P459 - Prevalence and risk factors of anxiety and depression in relatives of burn patients.

          P. Morelli, M. Degiovanangelo, F. Lemos, V. MArtinez, F. Verga, J. Cabrera, G. Burghi

          P460 - Guidance of visiting children at an adult intensive care unit (icu)

          A. Rutten , S. Van Ieperen, S. De Geer, M. Van Vugt, E. Der Kinderen

          P461 - Visiting policies in Italian pediatric ICUs: an update

          A. Giannini, G Miccinesi, T Marchesi, E Prandi

          Related collections

          Most cited references2

          • Record: found
          • Abstract: found
          • Article: not found

          Psychosocial outcomes in informal caregivers of the critically ill: a systematic review.

          The objective of the review was to evaluate and synthesize the prevalence, risk factors, and trajectory of psychosocial morbidity in informal caregivers of critical care survivors.
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            • Record: found
            • Abstract: found
            • Article: not found

            Employment, social dependency and return to work after intensive care

            Quality of life is an important measure of outcome in intensive care survivors. As return to employment is a key determinant of quality of life, we performed a prospective observational, cohort study of 75 intensive care unit patients who survived to hospital discharge. Approximately 2 years after intensive care unit discharge, 64% (18/28) of those employed before intensive care unit had returned to work. Of the rest, 10 were not working, two were unemployed, one was temporarily sick and seven were permanently sick. When health utility scores were assessed in the various employment categories, quality of life was particularly poor in the unemployed and permanently sick with median (interquartile range) scores of 0.082(−0.045−0.665) and 0.053(−0.160−0.769) respectively. Of the retired population, 95% returned to their own home with 50% requiring a family member to act as their carer. This study has demonstrated that patients who returned to work after a critical illness had a better quality of life at follow up, compared to the unemployed and permanently sick. In addition, there may be a burden on family members who act as carers for their relatives on discharge from hospital after a critical illness. Further work is required in this important area.
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              Author and article information

              Conference
              Crit Care
              Critical Care
              BioMed Central (London )
              1364-8535
              1466-609X
              20 April 2016
              20 April 2016
              2016
              : 20
              Issue : Suppl 2 Issue sponsor : Publication charges for this supplement were funded by ISICEM.
              : 94
              Affiliations
              [1 ]ISNI 0000 0004 1936 8884, GRID grid.39381.30, , University of Western Ontario, ; London, Canada
              [2 ]Hospital Dr Negrín, Las Palmas de GC, Spain
              [3 ]ISNI 0000 0004 1765 5935, GRID grid.415076.1, , Hospital San Jorge, ; Huesca, Spain
              [4 ]ISNI 0000 0004 1767 8811, GRID grid.411142.3, , Hospital Universitari del Mar, ; Barcelona, Spain
              [5 ]ISNI 0000 0004 1767 647X, GRID grid.411251.2, , Hospital Universitario de la Princesa, ; Madrid, Spain
              [6 ]GRID grid.411308.f, , Hospital Clínico y Universitario de Valencia, ; Valencia, Spain
              [7 ]ISNI 0000 0004 1796 5984, GRID grid.411164.7, , Hospital Universitari Son Espases, ; Palma de Mallorca, Spain
              [8 ]ISNI 0000 0001 2166 6619, GRID grid.9601.e, Medical Faculty of Istanbul, , Istanbul University, Anesthesiology and Intensive Care, ; Istanbul, Turkey
              [9 ]ISNI 0000 0001 2166 6619, GRID grid.9601.e, Medical Faculty of Istanbul, Physiology, , Istanbul University, ; Istanbul, Turkey
              [10 ]ISNI 0000 0001 2166 6619, GRID grid.9601.e, Institute of Experimental Medicine, , Istanbul University, Neuroscience, ; Istanbul, Turkey
              [11 ]ISNI 0000 0001 2166 6619, GRID grid.9601.e, Medical Faculty of Istanbul, Forensic Medicine, , Istanbul University, ; Istanbul, Turkey
              [12 ]ISNI 0000 0001 2166 6619, GRID grid.9601.e, Institute of Experimental Medicine, Immunology, , Istanbul University, ; Istanbul, Turkey
              [13 ]ISNI 0000 0004 1937 0511, GRID grid.7489.2, , Ben-Gurion University of the Negev, ; Beer-Sheva, Israel
              [14 ]ISNI 0000 0004 0470 8989, GRID grid.412686.f, , Soroka Medical Center, ; Beer-Sheva, Israel
              [15 ]ISNI 0000 0004 0373 3971, GRID grid.136593.b, , Osaka University Graduate School of Medicine, ; Suita, Japan
              [16 ]ISNI 0000 0000 8902 2273, GRID grid.174567.6, , Nagasaki University Graduate School of Biomedical Sciences, ; Nagasaki, Japan
              [17 ]GRID grid.411909.4, , Tokyo Medical University Hachioji Medical Center, ; Hachioji, Tokyo Japan
              [18 ]ISNI 0000 0004 0374 0880, GRID grid.416614.0, , National Defense Medical College, ; Tokorozawa, Saitama Japan
              [19 ]ISNI 0000 0004 0373 3971, GRID grid.136593.b, , Osaka University Graduate School of Medicine, ; Suita, Japan
              [20 ]ISNI 0000 0001 0663 3325, GRID grid.410793.8, Hachiouji medical center, , Tokyo medical university, ; Tokyo, Japan
              [21 ]ISNI 0000 0001 2308 3329, GRID grid.9707.9, , Kanazawa University, ; Kanazawa, Japan
              [22 ]ISNI 0000 0004 0615 9100, GRID grid.412002.5, , Kanazawa University Hospital, ; Kanazawa, Japan
              [23 ]ThermoFisher, Hennigsdorf, Germany
              [24 ]Institut für Klinische Chemie und Laboratoriumsmedizin, Mainz, Germany
              [25 ]MVZ Labor Limbach Gruppe, Berlin, Germany
              [26 ]ISNI 0000 0000 8704 3732, GRID grid.413357.7, , Kantonsspital Aarau, ; Aarau, Switzerland
              [27 ]ISNI 0000 0001 2191 4301, GRID grid.415310.2, , King Faisal Specialist Hospital & Research Center, ; Riyadh, Saudi Arabia
              [28 ]GRID grid.416564.4, , Saint Savvas Hospital, ; Athens, Greece
              [29 ]ISNI 0000 0001 0663 3325, GRID grid.410793.8, , Tokyo Medical University, ; Tokyo, Japan
              [30 ]GRID grid.411909.4, Tokyo Medical University, , Hachioji Medical Center, ; Tokyo, Japan
              [31 ]ISNI 0000 0000 9788 2492, GRID grid.411062.0, , Hospital Virgen de la Victoria, ; Málaga, Spain
              [32 ]St Helens and Knowsley NHS Trust, Merseyside, UK
              [33 ]ISNI 0000 0001 0481 6099, GRID grid.5012.6, , Maastricht University, ; Maastricht, Netherlands
              [34 ]Center for Experimental and Molecular medicine, Amsterdam, Netherlands
              [35 ]ISNI 0000000404654431, GRID grid.5650.6, , Academic Medical Center, ; Amsterdam, Netherlands
              [36 ]NISCHR Haemostasis Biomarker Research Unit, Swansea, UK
              [37 ]ISNI 0000 0000 9725 279X, GRID grid.411296.9, , Hôpital Lariboisière, ; Paris, France
              [38 ]Sphingotec, Berlin, Germany
              [39 ]ISNI 0000 0001 0274 3893, GRID grid.411784.f, , Hôpital Cochin, ; Paris, France
              [40 ]ISNI 0000 0004 1937 1100, GRID grid.412370.3, , Hôpital Saint-Antoine, ; Paris, France
              [41 ]ISNI 0000 0000 9961 060X, GRID grid.157868.5, , CHRU de Montpellier, ; Montpellier, France
              [42 ]ISNI 0000 0001 2300 6614, GRID grid.413328.f, , Hôpital Saint-Louis, ; Paris, France
              [43 ]ISNI 0000 0001 0407 1584, GRID grid.414336.7, , AP-HM, ; Marseille, France
              [44 ]ISNI 0000 0000 9982 5352, GRID grid.413756.2, , Hôpital Ambroise Paré, ; Paris, France
              [45 ]ISNI 0000 0004 0444 1241, GRID grid.414316.5, , Christiana Care Health System, ; Newark, USA
              [46 ]ISNI 0000 0001 0930 2361, GRID grid.4514.4, Skane University Hospital, , Lund University, ; Lund, Sweden
              [47 ]ISNI 0000 0000 9828 7548, GRID grid.8194.4, , Carol Davila University of Medicine and Pharmacy, ; Bucharest, Romania
              [48 ]ISNI 0000 0001 2221 2926, GRID grid.17788.31, , Hadassah-Hebrew University Medical Center, ; Jerusalem, Israel
              [49 ]LeukoDx, Jerusalem, Israel
              [50 ]Abionic SA, Lausanne, Switzerland
              [51 ]Swiss Federal Laboratories (Empa), St. Gallen, Switzerland
              [52 ]Pathophysiology of injury induced immunosuppression (PI3) Lab, Lyon 1 University / Hospices Civils de Lyon / bioMérieux, Lyon, France
              [53 ]Negovsky V.A. Research Institute of General Reanimatology, Moscow, Russia
              [54 ]ISNI 0000 0000 8704 3732, GRID grid.413357.7, , Kantonsspital Aarau, ; Aarau, Switzerland
              [55 ]GRID grid.410567.1, , University Hospital Basel, ; Basel, Switzerland
              [56 ]ISNI 0000 0001 0514 7202, GRID grid.411249.b, , UNIFESP, ; Sao Paulo, Brazil
              [57 ]ISNI 0000 0001 0385 1941, GRID grid.413562.7, , Albert Einstein Hospital, ; Sao Paulo, Brazil
              [58 ]Sírio Libanês Hospital, Sao Paulo, Brazil
              [59 ]ISNI 0000 0001 0738 8966, GRID grid.15895.30, , Faculty of Medicine and Health Örebro University, ; Örebro, Sweden
              [60 ]ISNI 0000 0000 9241 5705, GRID grid.24381.3c, Department of Infectious Diseases, , Karolinska University Hospital, ; Stockholm, Sweden
              [61 ]Faculty of Medicine and Health, Örebro, Sweden
              [62 ]ISNI 0000 0000 9241 5705, GRID grid.24381.3c, Center for Infectious Medicine, Karolinska Institutet, , Karolinska University Hospital, ; Stockholm, Sweden
              [63 ]NISCHR Haemostasis Biomarker Research Unit, Swansea, UK
              [64 ]NISCHR Haemostasis Biomarker Research Unit, Swansea, UK
              [65 ]NISCHR Haemostasis Biomarker Research Unit, Swansea, UK
              [66 ]ISNI 000000040459992X, GRID grid.5645.2, , Erasmus Medical Center, ; Rotterdam, Netherlands
              [67 ]ISNI 0000 0000 9024 6397, GRID grid.412581.b, , University Witten/Herdecke, ; Witten, Germany
              [68 ]ISNI 0000 0004 0460 0556, GRID grid.416213.3, , Maasstad Ziekenhuis, ; Rotterdam, Netherlands
              [69 ]ISNI 0000 0004 0460 774X, GRID grid.420884.2, , Intermountain Healthcare, ; Salt Lake City, USA
              [70 ]Immunexpress, Seattle, USA
              [71 ]GRID grid.429537.e, , Lewisham and Greenwich NHS Trust, ; London, UK
              [72 ]Wirral trust, Merseyside, UK
              [73 ]RLBUHT, Liverpool, UK
              [74 ]ISNI 0000 0004 0512 5013, GRID grid.7143.1, Department of Emergency Medicine, , Odense University Hospital, ; Odense C, Denmark
              [75 ]ISNI 0000 0004 0512 5013, GRID grid.7143.1, Department of Respiratory Medicine, , Odense University Hospital, ; Odense C, Denmark
              [76 ]ISNI 0000 0004 0512 5013, GRID grid.7143.1, Department of Anaesthesiology and Intensive Care Medicine, , Odense University Hospital, ; Odense C, Denmark
              [77 ]Bucharest Clinical Emergency Hospital, Bucharest, Romania
              [78 ]ISNI 0000 0004 0540 9980, GRID grid.415180.9, , Fundeni Clinical Institute, ; Bucharest, Romania
              [79 ]ISNI 0000000404654431, GRID grid.5650.6, , Amsterdam Medical Center, ; Amsterdam, Netherlands
              [80 ]ISNI 0000000090126352, GRID grid.7692.a, , University Medical Center Utrecht, ; Utrecht, Netherlands
              [81 ]ISNI 0000 0004 0419 1043, GRID grid.414177.0, , Bakirkoy Dr.Sadi Konuk Training and Research Hospital, ; Istanbul, Turkey
              [82 ]ISNI 0000 0004 0608 0662, GRID grid.412149.b, , King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, ; Riyadh, Saudi Arabia
              [83 ]GRID grid.429537.e, , Lewisham and Greenwich NHS Trust, ; London, UK
              [84 ]Assaf Harofeh MC, Beer Yaakov, Israel
              [85 ]ISNI 0000 0001 1939 2794, GRID grid.9613.d, , Jena University Hopital, ; Jena, Germany
              [86 ]ISNI 0000 0004 0470 1162, GRID grid.7130.5, , Prince of Songkla University, ; Hat Yai, Thailand
              [87 ]Division of Critical Care Medicine, Hat Yai, Thailand
              [88 ]ISNI 0000 0000 9825 7840, GRID grid.411714.6, , Glasgow Royal Infirmary, ; Glasgow, UK
              [89 ]ISNI 0000 0004 0609 0692, GRID grid.412727.5, , University Hospital and Faculty of Medicine Ostrava University, ; Ostrava, Czech Republic
              [90 ]ISNI 0000 0001 2194 0956, GRID grid.10267.32, Institute of Biostatistics and analyses, , Masaryk University, ; Brno, Czech Republic
              [91 ]ISNI 0000 0004 1762 5736, GRID grid.8982.b, , Università degli studi di Pavia, scuola di specialità: Anestesia e Rianimazione, ; Pavia, Italy
              [92 ]UOC Anestesia e Rianimazione Ospedale Civile di Vigevano, AO Pavia, Vigevano, Italy
              [93 ]ISNI 0000 0004 1762 5736, GRID grid.8982.b, , Università degli studi di Pavia, ; Pavia, Italy
              [94 ]Hospital O’horan, Mérida, Mexico
              [95 ]ISNI 0000 0001 1090 049X, GRID grid.4495.c, Department of Anaesthesiology and Intensive Therapy, , Medical University, ; Wroclaw, Poland
              [96 ]AKPA, Waltham, USA
              [97 ]ISNI 0000 0000 8589 2327, GRID grid.416553.0, , St. Paul’s Hospital, ; Vancouver, Canada
              [98 ]ISNI 0000 0004 0540 9980, GRID grid.415180.9, , Fundeni Clinical Institute, ; Bucharest, Romania
              [99 ]ISNI 0000 0000 9828 7548, GRID grid.8194.4, , University of Medicine and Pharmacy “Carol Davila”, ; Bucharest, Romania
              [100 ]Acedemisch Medisch Centrum, Amsterdam, Netherlands
              [101 ]ISNI 0000 0000 9116 8976, GRID grid.412469.c, , University Hospital of Greifswald, ; Greifswald, Germany
              [102 ]ISNI 0000 0004 0373 3971, GRID grid.136593.b, Division of Infection Control and Prevention, , Osaka University Graduate School of Medicine, ; Suita, Japan
              [103 ]ISNI 0000 0004 0373 3971, GRID grid.136593.b, Department of Traumatology and Acute Critical Medicine, , Osaka University Graduate School of Medicine, ; Suita, Japan
              [104 ]ISNI 0000 0000 8902 2273, GRID grid.174567.6, Department of Emergency Medicine, , Nagasaki University Graduate School of Biomedical Sciences, ; Nagasaki, Japan
              [105 ]ISNI 0000 0000 9274 367X, GRID grid.411057.6, , Hospital Clínico Universitario de Valladolid, ; Valladolid, Spain
              [106 ]ISNI 0000 0000 8517 6224, GRID grid.275559.9, , Jena University Hospital, ; Jena, Germany
              [107 ]Medica Superspecialty Hospital, Kolkata, West Bengal India
              [108 ]Assaf Harofeh MC, Beer Yaakov, Israel
              [109 ]ISNI 0000 0001 0088 6903, GRID grid.413184.b, , DMC, ; Detroit, USA
              [110 ]ISNI 0000 0001 1456 7807, GRID grid.254444.7, , Wayne State University, ; Detroit, USA
              [112 ]ISNI 0000 0004 0635 3376, GRID grid.418170.b, , Scientific Institute of Public Health (WIV-ISP), ; Brussels, Belgium
              [113 ]ISNI 0000 0001 2069 7798, GRID grid.5342.0, , Ghent University, ; Ghent, Belgium
              [114 ]Erasme University, Brussels, Belgium
              [115 ]QualityLabs Bt GmbH, Nuremberg, Germany
              [116 ]ISNI 0000 0001 0699 8877, GRID grid.462046.2, , B.Braun Melsungen AG, ; Melsungen, Germany
              [117 ]Dr. Roschke medical marketing GmbH, Cologne, Germany
              [118 ]Bucharest Clinical Emergency Hospital, Bucharest, Romania
              [119 ]ISNI 0000 0004 0540 9980, GRID grid.415180.9, , Fundeni Clinical Institute, ; Bucharest, Romania
              [120 ]Nakhonpathom hospital, Nakhonpathom, Thailand
              [121 ]ISNI 0000 0004 0432 6841, GRID grid.45083.3a, , Lithuanian University of Health Sciences, ; Kaunas,, Lithuania
              [122 ]University Hospital North Midlands, Stoke-on-Trent, UK
              [123 ]EPS Charles-Nicolle, Bab Saadoun, Tunisia
              [124 ]Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi County, Taiwan
              [125 ]ISNI 0000000084992262, GRID grid.7177.6, Academic Medical Center, , University of Amsterdam, ; Amsterdam, Netherlands
              [126 ]Academic Medical Center, University of Amsterdam, Center for Experimental and Molecular Medicine, Amsterdam, Netherlands
              [127 ]ISNI 0000000090126352, GRID grid.7692.a, Department of Intensive Care Medicine, , University Medical Center Utrecht, ; Utrecht, Netherlands
              [128 ]ISNI 0000000404654431, GRID grid.5650.6, Department of Intensive Care Medicine, , Academic Medical Center, University of Amsterdam, ; Amsterdam, Netherlands
              [129 ]ISNI 0000000090126352, GRID grid.7692.a, Department of Medical Microbiology, , University Medical Center Utrecht, ; Utrecht, Netherlands
              [130 ]ISNI 0000 0000 9825 7840, GRID grid.411714.6, , Glasgow Royal Infirmary, ; Glasgow, UK
              [131 ]ISNI 0000 0001 0523 9342, GRID grid.413301.4, , NHS Greater Glasgow and Clyde, ; Glasgow, UK
              [132 ]ISNI 0000 0001 2232 4338, GRID grid.413893.4, , Health Protection Scotland, ; Glasgow, UK
              [133 ]ISNI 0000 0001 2196 8713, GRID grid.9004.d, , Public Health England, ; London, UK
              [134 ]ISNI 0000 0004 0594 9821, GRID grid.411556.2, , Fukuoka University Hospital, ; Fukuoka, Japan
              [135 ]ISNI 0000 0004 0608 0662, GRID grid.412149.b, , King Saud bin Abdulaziz University for Health Sciences, ; Riyadh, Saudi Arabia
              [136 ]GRID grid.411600.2, Toxicological Research Center, Department of Clinical Toxicology, Loghman-Hakim Hospital, , Shahid Beheshti University of Medical Sciences, ; Tehran, Iran
              [137 ]GRID grid.416373.4, , St. Elisabeth Hospital, ; Tilburg, Netherlands
              [138 ]Mongi Slim University Hospital, La Marsa, Tunisia
              [139 ]ISNI 0000 0001 2155 0800, GRID grid.5216.0, University of Athens, , Medical School, ; Athens, Greece
              [140 ]Korgialeneion Benakeion Hospital, Athens, Greece
              [141 ]ISNI 0000 0001 2170 8022, GRID grid.12284.3d, , University of Thrace, ; Alexandroupolis, Greece
              [142 ]Aghios Dimitrios Hospital, Thessaloniki, Greece
              [143 ]Tzaneion Hospital, Piraeus, Greece
              [144 ]GRID grid.414012.2, , G.Gennimatas General Hospital, ; Thessaloniki, Greece
              [145 ]ISNI 0000 0001 2108 7481, GRID grid.9594.1, , University of Ioannina, ; Ioannina, Greece
              [146 ]ISNI 0000 0004 0576 574X, GRID grid.415248.e, , G.Papanikolaou General Hospital, ; Thessaloniki, Greece
              [147 ]ISNI 0000 0004 0576 5395, GRID grid.11047.33, , University of Patras, ; Patras, Greece
              [148 ]ISNI 0000 0000 8970 9163, GRID grid.81821.32, , Hospital Universitario La Paz, ; Madrid, Spain
              [149 ]ISNI 0000 0000 9375 4688, GRID grid.414556.7, , Centro Hospitalar São João, ; Porto, Portugal
              [150 ]PSMMC, Riyadh, Saudi Arabia
              [151 ]UNIKLINIKUM JENA, JENA, Germany
              [152 ]ISNI 0000 0004 0608 0662, GRID grid.412149.b, , King Saud bin Abdulaziz University for Health Sciences, ; Riyadh, Saudi Arabia
              [153 ]ISNI 0000 0004 0608 0662, GRID grid.412149.b, , King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, ; Riyadh, Saudi Arabia
              [154 ]ISNI 0000 0004 0593 1832, GRID grid.415277.2, , King Fahad Medical City, ; Riyadh, Saudi Arabia
              [155 ]ISNI 0000 0004 0622 5016, GRID grid.120073.7, , Addenbrooke’s Hospital, ; Cambridge, UK
              [156 ]ISNI 0000000121885934, GRID grid.5335.0, , University of Cambridge, ; Cambridge, UK
              [157 ]ISNI 0000 0004 0417 0728, GRID grid.416091.b, , Royal United Hospital, ; Bath, UK
              [158 ]ISNI 0000 0000 9274 367X, GRID grid.411057.6, , Hospital Clínico Universitario de Valladolid, ; Valladolid, Spain
              [159 ]ISNI 0000 0000 8535 2371, GRID grid.415721.4, , Salford Royal Hospital, ; London, UK
              [160 ]ISNI 0000 0000 9206 4546, GRID grid.414021.2, , Hennepin County Medical Center, ; Minneapolis, USA
              [161 ]ISNI 0000 0001 1481 5225, GRID grid.412212.6, , CHU Dupuytren, ; Limoges, France
              [162 ]ISNI 0000 0004 0461 6320, GRID grid.48769.34, , St Luc University Hospital, ; Brussels, Belgium
              [163 ]ISNI 0000 0001 0423 4662, GRID grid.8515.9, , CHUV, ; Lausanne, Switzerland
              [164 ]ISNI 0000 0000 9635 9413, GRID grid.410458.c, , Hospital Clinic of Barcelona, ; Barcelona, Spain
              [165 ]ISNI 0000 0001 0671 5785, GRID grid.411068.a, , Hospital Clínico San Carlos, ; Madrid, Spain
              [166 ]ISNI 0000 0001 2182 6141, GRID grid.12366.30, , Université François Rabelais and CHU Bretonneau, ; Tours, France
              [167 ]ISNI 0000 0001 2150 9058, GRID grid.411439.a, , Groupe Hospitalier Pitié-Salpêtrière, ; Paris, France
              [168 ]GRID grid.418152.b, , MedImmune, ; Gaithersburg, USA
              [169 ]Mongi Slim University Hospital, La Marsa, Tunisia
              [170 ]Xanthi General Hospital, Xanthi, Greece
              [171 ]ISNI 0000 0001 0709 1919, GRID grid.418716.d, , Royal Infirmary of Edinburgh, ; Edinburgh, UK
              [172 ]ISNI 0000 0001 2232 4338, GRID grid.413893.4, , Health Protection Scotland, ; Glasgow, UK
              [173 ]ISNI 0000 0004 0624 9907, GRID grid.417068.c, , Western General Hospital, ; Edinburgh, UK
              [174 ]ISNI 0000 0004 1762 5736, GRID grid.8982.b, Fondazione IRCCS Policlinico S. Matteo, , University of Pavia, ; Pavia, Italy
              [175 ]GRID grid.31151.37, , Centre Hospitalier Universitaire Dijon, ; Dijon, France
              [176 ]ISNI 0000 0001 0668 8422, GRID grid.16477.33, , Marmara University Pendik Teaching and Research Hospital, ; Istanbul, Turkey
              [177 ]Xanthi General Hospital, Xanthi, Greece
              [178 ]GRID grid.419135.b, , Sheffield Teaching Hospital NHS Foundation Trust, ; Sheffield, UK
              [179 ]ISNI 0000 0001 2150 9058, GRID grid.411439.a, , Groupe Hospitalier Pitié-Salpêtrière, ; Paris, France
              [180 ]ISNI 0000 0001 1481 5225, GRID grid.412212.6, , CHU Dupuytren, ; Limoges, France
              [181 ]ISNI 0000 0000 9635 9413, GRID grid.410458.c, , Hospital Clinic of Barcelona, ; Barcelona, Spain
              [182 ]ISNI 0000 0001 0671 5785, GRID grid.411068.a, , Hospital Clínico San Carlos, ; Madrid, Spain
              [183 ]University College, London, UK
              [184 ]GRID grid.418152.b, , MedImmune, ; Gaithersburg, USA
              [185 ]ISNI 0000 0004 0639 9286, GRID grid.7776.1, , Cairo University, ; Giza, Egypt
              [186 ]University hospital Center of La Rabta, Tunis, Tunisia
              [187 ]ISNI 0000 0001 0668 8422, GRID grid.16477.33, , Marmara University Pendik Teaching and Research Hospital, ; Istanbul, Turkey
              [188 ]V.A. Negovsky Research Institute of General Reanimatology, Moscow, Russia
              [189 ]N.V. Sklifosofsky Institute of Emergency Medicine, Moscow, Russia
              [190 ]NN Burdenko Main Military Hospital, Moscow, Russia
              [191 ]ISNI 0000 0004 0439 2056, GRID grid.418424.f, , Novartis Pharmaceuticals, ; San Carlos, USA
              [192 ]ISNI 0000 0004 0410 3955, GRID grid.476522.0, , Nektar Therapeutics, ; San Francisco, CA USA
              [193 ]ISNI 0000 0000 9635 9413, GRID grid.410458.c, , Hospital Clinic, ; Barcelona, Spain
              [194 ]ISNI 0000000404654431, GRID grid.5650.6, , Academic Medical Center, ; Amsterdam, Netherlands
              [195 ]GRID grid.240160.1, , Maine Medical Center, ; Portland, USA
              [196 ]ISNI 0000 0000 9259 8492, GRID grid.22937.3d, , Medical University of Vienna, ; Vienna, Austria
              [197 ]GRID grid.411600.2, Toxicological Research Center, Department of Clinical Toxicology, Loghman-Hakim Hospital, , Shahid Beheshti University of Medical Sciences, ; Tehran, Iran
              [198 ]ISNI 0000 0004 1795 3756, GRID grid.414028.b, , HIA Percy, ; Clamart, France
              [199 ]Pherecydes Pharma, Romainville, France
              [200 ]Hôpital Reine Astrid, Brussels, Belgium
              [201 ]ISNI 0000 0001 0423 4662, GRID grid.8515.9, , CHUV, ; Lausanne, Switzerland
              [202 ]ISNI 0000 0000 8607 6858, GRID grid.411374.4, , CHU Liege, ; Liege, Belgium
              [203 ]CH Saint Jospeh Saint Luc, Lyon, France
              [204 ]ISNI 0000 0004 0608 0662, GRID grid.412149.b, , King Saud bin Abdulaziz University for Health Sciences, ; Riyadh, Saudi Arabia
              [205 ]University hospital center of La Rabta, Tunis, Tunisia
              [206 ]ISNI 0000 0004 0571 546X, GRID grid.413548.f, , Hamad Medical Corporation, ; Doha, Qatar
              [207 ]ISNI 0000 0000 8853 2677, GRID grid.5361.1, , MUI, ; Innsbruck, Austria
              [208 ]ISNI 0000000404654431, GRID grid.5650.6, , Academic Medical Centre, ; Amsterdam, Netherlands
              [209 ]ISNI 0000000404654431, GRID grid.5650.6, , Academic Medical Center Amsterdam, ; Amsterdam, Netherlands
              [210 ]ISNI 0000 0001 2234 6887, GRID grid.417732.4, , Sanquin, ; Amsterdam, Netherlands
              [211 ]ISNI 0000 0004 0622 8129, GRID grid.415070.7, , KAT Hospital Athens, ; Kifisia, Greece
              [212 ]ICU-B, KAT Hospital Kifisia, Athens, Greece
              [213 ]ISNI 0000 0000 9206 4546, GRID grid.414021.2, , Hennepin County Medical Center, ; Minneapolis, USA
              [214 ]ISNI 0000 0004 0378 6088, GRID grid.412167.7, , Hokkaido University Hospital, ; Sapporo, Japan
              [215 ]ISNI 0000 0001 2248 6943, GRID grid.69566.3a, , Tohoku University Graduate School of Medicine, ; Sendai, Japan
              [216 ]GRID grid.474906.8, , Tokyo Medical and Dental University Hospital of Medicine, ; Tokyo, Japan
              [217 ]ISNI 0000 0004 0569 9594, GRID grid.416797.a, , National Hospital Organization Disaster Medical Center, ; Tokyo, Japan
              [218 ]ISNI 0000 0004 1936 9959, GRID grid.26091.3c, , Keio University School of Medicine, ; Tokyo, Japan
              [219 ]ISNI 0000 0004 0373 3971, GRID grid.136593.b, , Osaka University Graduate School of Medicine, ; Osaka, Japan
              [220 ]Rinku General Medical Center, Osaka, Japan
              [221 ]ISNI 0000 0004 1936 9967, GRID grid.258622.9, , Kinki University Faculty of Medicine, ; Osaka, Japan
              [222 ]ISNI 0000 0001 1033 6139, GRID grid.268441.d, , Yokohama City University Graduate School of Medicine, ; Yokohama, Japan
              [223 ]ISNI 0000 0001 0672 2176, GRID grid.411497.e, Faculty of Medicine, , Fukuoka University, ; Fukuoka, Japan
              [224 ]ISNI 0000 0004 0489 0290, GRID grid.45203.30, , National Center For Global Health and Medicine, ; Tokyo, Japan
              [225 ]ISNI 0000 0001 0720 6587, GRID grid.410818.4, , Tokyo Women’s Medical University, ; Tokyo, Japan
              [226 ]GRID grid.445907.b, , Odessa National Medical University, ; Odessa, Ukraine
              [227 ]ISNI 0000 0001 2160 7387, GRID grid.414056.2, , Hopital Sacré-Coeur de Montréal, ; Montreal, Canada
              [228 ]GRID grid.445907.b, , Odessa National Medical University, ; Odessa, Ukraine
              [229 ]GRID grid.414012.2, , Xanthi General Hospital, ; Xanth, Greece
              [230 ]GRID grid.412966.e, , Maastricht UMC, ; Maastricht, Netherlands
              [231 ]ISNI 0000 0004 0611 0905, GRID grid.412826.b, Second Faculty of Medicine, , Charles University and University Hospital Motol, ; Prague, Czech Republic
              [232 ]Sechenov First Moscow Stat Medical University, Moscow, Russia
              [233 ]ISNI 0000 0001 2107 2845, GRID grid.413795.d, , Sheba Medical Center, ; Tel-Hashomer, Israel
              [234 ]ISNI 0000 0004 0377 5418, GRID grid.417366.1, , Yokohama Municipal Citizen’s Hospital, ; Yokohama, Japan
              [235 ]Hayama Heart Center, Hayama, Japan
              [236 ]ISNI 0000 0004 1767 0473, GRID grid.470126.6, , Yokohama City University Hospital, ; Yokohama, Japan
              [237 ]Institute of Ageing and Chronic Disease, Liverpool, UK
              [238 ]Institute of Infection and Global Health, Liverpool, UK
              [239 ]ISNI 0000 0004 0417 2395, GRID grid.415970.e, Department of Haematology, , Royal Liverpool University Hospital (RLUH), ; Liverpool, UK
              [240 ]ISNI 0000 0001 2160 7387, GRID grid.414056.2, , Hôpital du Sacré-Coeur de Montréal, ; Montreal, Canada
              [241 ]Evelina London Children’s Hospital, London, UK
              [242 ]GRID grid.425213.3, , St Thomas Hospital, ; London, UK
              [243 ]ISNI 0000 0004 0576 574X, GRID grid.415248.e, , G.Papanikolaou General Hospital, ; Thessaloniki, Greece
              [244 ]ISNI 0000 0004 1757 2064, GRID grid.8484.0, Intensive Care Unit, , University of Ferrara, Italy, ; Ferrara, Italy
              [245 ]Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, Bruxelles, Belgium
              [246 ]ISNI 0000 0004 0621 2899, GRID grid.414122.0, , Hippokration General Hospital Thessaloniki, ; Thessaloniki, Greece
              [247 ]ISNI 0000 0004 0649 0266, GRID grid.416122.2, , Morriston Hospital, ; Swansea, UK
              [248 ]Central London School of Anaesthesia and Intensive Care Medicine, London, UK
              [249 ]ISNI 0000 0001 1555 3415, GRID grid.1034.6, , University of the Sunshine Coast, ; Maroochydore, Australia
              [250 ]ISNI 0000 0004 1936 7988, GRID grid.4305.2, , University of Edinburgh, ; Edinburgh, UK
              [251 ]ISNI 0000 0001 2306 7492, GRID grid.8348.7, , John Radcliffe Hospital, ; Oxford, UK
              [252 ]ISNI 0000 0004 0646 7373, GRID grid.4973.9, , Copenhagen University Hospital, ; Copenhagen, Denmark
              [253 ]Peterborough NHS Trust, Peterborough, UK
              [254 ]ISNI 0000 0001 1956 2722, GRID grid.7048.b, , Aarhus University, ; Aarhus, Denmark
              [255 ]GRID grid.413463.7, , Hospital de Sao Paulo, ; Sao Paulo, Brazil
              [256 ]ISNI 0000 0004 0581 2008, GRID grid.451052.7, , Royal Brompton & Harefield NHS Trust, ; London, UK
              [257 ]Barts Heart Centre, London, UK
              [258 ]ISNI 0000 0004 0571 546X, GRID grid.413548.f, , Hamad medical corporation, ; Doha, Qatar
              [259 ]ISNI 0000 0004 0576 574X, GRID grid.415248.e, , G.Papanikolaou General Hospital, ; Thessaloniki, Greece
              [260 ]ISNI 0000 0004 1937 0722, GRID grid.11899.38, , University of Sao Paulo, Brazi, ; Sao Paulo, Brazil
              [261 ]GRID grid.411966.d, , Juntendo University Hospital, ; Tokyo, Japan
              [262 ]ISNI 0000000123090000, GRID grid.410804.9, Saitama Medical Center, , Jichi Medical University, ; Saitama, Japan
              [263 ]ISNI 0000 0004 0595 7039, GRID grid.411887.3, , Gunma University Hospital, ; Maebashi, Japan
              [264 ]Yokohama City Minato Red Cross Hospital, Yokohama, Japan
              [265 ]GRID grid.474906.8, , Tokyo Medical and Dental University Hospital of Medicine, ; Tokyo, Japan
              [266 ]ISNI 0000 0004 0571 546X, GRID grid.413548.f, , Hamad medical corporation, ; Doha, Qatar
              [267 ]Research Institution for Cardiology, Tomsk, Russia
              [268 ]ISNI 0000 0001 0027 1685, GRID grid.412593.8, , Siberian State Medical University, ; Tomsk, Russia
              [269 ]ISNI 0000 0004 0476 7073, GRID grid.440199.1, , The Hillingdon Hospitals NHS Foundation Trust, ; Middlesex, UK
              [270 ]ISNI 0000 0001 1842 3755, GRID grid.411280.e, , University Hospital Rio Hortega, ; Valladolid, Spain
              [271 ]ISNI 000000040459992X, GRID grid.5645.2, , Erasmus MC, ; Rotterdam, Netherlands
              [272 ]ISNI 0000 0004 1773 3278, GRID grid.415670.1, , Sheikh Khalifa Medical City, ; Abu Dhabi, United Arab Emirates
              [273 ]Intensive Care Unit, St. Boniface Hospital, Verona, Italy
              [274 ]Intensive Care Unit, St. Boniface Hospital, Verona, Italy
              [275 ]ISNI 0000 0004 1936 9000, GRID grid.21925.3d, , University of Pittsburgh, ; Pittsburgh, USA
              [276 ]ISNI 0000 0001 2097 0344, GRID grid.147455.6, , Carnegie Mellon University, ; Pittsburgh, USA
              [277 ]ISNI 0000 0004 1768 1690, GRID grid.412800.f, , Valme University Hospital, ; Seville, Spain
              [278 ]ISNI 0000 0001 1842 3755, GRID grid.411280.e, , University Hospital Rio Hortega, ; Valladolid, Spain
              [279 ]ISNI 000000040459992X, GRID grid.5645.2, , Erasmus MC, ; Rotterdam, Netherlands
              [280 ]ISNI 0000 0004 0593 702X, GRID grid.134996.0, , CHU Amiens, ; Amiens, France
              [281 ]CH Beauvais, Beauvais, France
              [282 ]Réanimation polyvalente, Le Havre, France
              [283 ]ISNI 0000 0004 0608 7784, GRID grid.477297.8, , CH Roubaix, ; Roubaix, France
              [284 ]CH Cotentin, Cherbourg, France
              [285 ]GRID grid.41724.34, , CHU Rouen, ; Rouen, France
              [286 ]ISNI 0000 0004 0471 8845, GRID grid.410463.4, , CHU Lille, ; Lille, France
              [287 ]ISNI 0000 0004 0472 0160, GRID grid.411149.8, , CHU Caen, ; Caen, France
              [288 ]ISNI 0000 0001 2191 4301, GRID grid.415310.2, , King Faisal Specialist Hospital & Research Center, ; Riyadh, Saudi Arabia
              [289 ]ISNI 0000 0004 0593 702X, GRID grid.134996.0, , CHU Amiens, ; Amiens, France
              [290 ]ISNI 0000 0001 2180 3484, GRID grid.13648.38, , University Medical Center Hamburg-Eppendorf, ; Hamburg, Germany
              [291 ]Intensive Care Unit, St. Boniface Hospital, Verona, Italy
              [292 ]ISNI 0000 0004 0469 8354, GRID grid.411371.1, , Brugmann Hospital, ; Brussels, Belgium
              [293 ]Hospital Universitario del Tajo, Aranjuez, Spain
              [294 ]ISNI 0000 0004 1765 5855, GRID grid.411338.c, , Hospital Universitario Príncipe de Asturias, ; Alcalá de Henares, Spain
              [295 ]ISNI 0000 0001 0671 5785, GRID grid.411068.a, , Hospital Universitario de San Carlos, ; Madrid, Spain
              [296 ]ISNI 0000000123222966, GRID grid.6936.a, Klinikum rechts der Isar, , Technical University of Munich, ; Munich, Germany
              [297 ]ISNI 0000 0004 0479 0855, GRID grid.411656.1, Department of Intensive Care Medicine, , University Hospital Bern, ; Bern, Switzerland
              [298 ]Institute of Clinical Sciences at the Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden
              [299 ]GRID grid.451349.e, , St George’s Healthcare NHS Trust, ; London, UK
              [300 ]GRID grid.451349.e, , St George’s Healthcare NHS Trust, ; London, UK
              [301 ]ISNI 0000 0004 1937 0626, GRID grid.4714.6, , Karolinska Institutet, ; Stockholm, Sweden
              [302 ]ISNI 0000 0004 1937 0626, GRID grid.4714.6, , Karolinska Institutet, ; Stockholm, Sweden
              [303 ]ISNI 0000 0001 0348 3990, GRID grid.268099.c, , Wenzhou Medical University, ; Wenzhou, Zheijang China
              [304 ]ISNI 0000 0001 0162 7225, GRID grid.414094.c, Department of Intensive Care, , Austin Hospital, ; Melbourne, VIC Australia
              [305 ]Hospital O’horan, Mérida, Mexico
              [306 ]ISNI 0000 0004 1769 5275, GRID grid.413363.0, , Policlinico Modena, ; Bologna, Italy
              [307 ]Clinical Hospital Sveti Duh, Zagreb, Croatia
              [308 ]GRID grid.451349.e, , St George’s Healthcare NHS Trust, ; London, UK
              [309 ]ISNI 0000 0000 9984 5644, GRID grid.413314.0, , The Canberra Hospital, ; Hughes, ACT Australia
              [310 ]ISNI 0000 0001 2180 7477, GRID grid.1001.0, , Australian National University Medical School, ; Canberra, Australia
              [311 ]ISNI 0000 0004 0638 8990, GRID grid.411572.4, , Lapeyronie University Hospital, ; Montpellier, France
              [312 ]ISNI 0000 0004 0378 8294, GRID grid.62560.37, , Brigham and Women’s Hospital, ; Boston, USA
              [313 ]Trexin Medical, Chicago, USA
              [314 ]ISNI 0000000107903411, GRID grid.241116.1, , University of Colorado and Denver Health, ; Denver, USA
              [315 ]Beth Isreal Deaconess, Boston, USA
              [316 ]Mongi Slim University Hospital, La Marsa, Tunisia
              [317 ]ISNI 0000 0004 0392 7039, GRID grid.418340.a, , Centro Hospitalar do Porto, ; Porto, Portugal
              [318 ]ISNI 0000 0004 0626 3303, GRID grid.410566.0, , University Hospital, ; Ghent, Belgium
              [319 ]City Clinical Hospital 40, Yekaterinburg, Russia
              [320 ]ISNI 0000 0004 0551 4246, GRID grid.16149.3b, , University Hospital Muenster, ; Muenster, Germany
              [321 ]Marienhospital Osnabrück, Osnabrück, Germany
              [322 ]Charité, University of Berlin, Berlin, Germany
              [323 ]GRID grid.7841.a, , Sapienza University of Rome, ; Rome, Italy
              [324 ]ISNI 0000 0000 9116 8976, GRID grid.412469.c, , University Hospital of Greifswald, ; Greifswald, Germany
              [325 ]ISNI 0000 0004 0551 4246, GRID grid.16149.3b, , University Hospital of Muenster, ; Muenster, Germany
              [326 ]ISNI 0000 0000 9116 8976, GRID grid.412469.c, , University Hospital of Greifswald, ; Greifswald, Germany
              [327 ]ISNI 000000040459992X, GRID grid.5645.2, , Erasmus MC University Hospital Rotterdam, ; Rotterdam, Netherlands
              [328 ]ISNI 0000 0004 0445 6830, GRID grid.415117.7, , Medical Research Institute of New Zealand, ; Wellington, New Zealand
              [329 ]ISNI 0000 0004 1936 7857, GRID grid.1002.3, , Monash University, ; Melbourne, Australia
              [330 ]ISNI 0000 0001 0162 7225, GRID grid.414094.c, , Austin Hospital, ; Melbourne, Australia
              [331 ]ISNI 0000 0000 8862 6892, GRID grid.416979.4, , Wellington Regional Hospital, ; Wellington, New Zealand
              [332 ]ISNI 0000 0004 0445 6830, GRID grid.415117.7, , Medical Research Institute of New Zealand, ; Wellington, New Zealand
              [333 ]Australian and New Zealand Intensive Care Research Centre, Melbourne, Australia
              [334 ]ISNI 0000 0001 0162 7225, GRID grid.414094.c, , Austin Hospital, ; Melbourne, Australia
              [335 ]ISNI 0000 0004 0648 9337, GRID grid.415249.f, , Princess of Wales Hospital, ; Bridgend, UK
              [336 ]ISNI 0000 0001 2113 8111, GRID grid.7445.2, , Imperial College London, ; London, UK
              [337 ]ISNI 0000 0000 9831 5916, GRID grid.415564.7, , Glan Clwyd Hospital, ; Bodelwyddan, UK
              [338 ]ISNI 0000 0004 0617 9371, GRID grid.412440.7, , University Hospital Galway, ; Galway, Ireland
              [339 ]Albert Schweitzer State Hospital, Rio de Janeiro, Brazil
              [340 ]GRID grid.240988.f, , Tan Tock Seng Hospital, ; Singapore, Singapore
              [341 ]ISNI 0000 0004 0636 696X, GRID grid.276809.2, , National Neuroscience Institute, ; Singapore, Singapore
              [342 ]ISNI 000000040459992X, GRID grid.5645.2, , Erasmus Medical Centre, ; Rotterdam, Netherlands
              [343 ]GRID grid.466592.a, , Centro Hospitalar Tamega e Sousa, ; Penafiel, Portugal
              [344 ]ISNI 0000 0004 0392 7039, GRID grid.418340.a, , Centro Hospitalar do Porto, ; Porto, Portugal
              [345 ]Unidade Local de Saude do Alto Minho, Viana do Castelo, Portugal
              [346 ]South Tees NHS Trust, Middlesbrough, UK
              [347 ]ISNI 0000 0004 0568 7120, GRID grid.414565.7, , Ikazia Hospital, ; Rotterdam, Netherlands
              [348 ]ISNI 000000040459992X, GRID grid.5645.2, , Erasmus MC, ; Rotterdam, Netherlands
              [349 ]Sheffiled Teaching Hospitals, Sheffield, UK
              [350 ]ISNI 0000 0004 0417 1894, GRID grid.417083.9, , Whiston Hospital, ; St Helens & Knowsley, UK
              [351 ]ISNI 0000 0000 8922 7789, GRID grid.14778.3d, , University Hospital Duesseldorf, ; Düsseldorf, Germany
              [352 ]ISNI 0000 0001 2218 4662, GRID grid.6363.0, , Charite University Hospital, ; Berlin, Germany
              [353 ]ISNI 0000 0001 0738 5466, GRID grid.416041.6, , Royal London Hospital, ; London, UK
              [354 ]GRID grid.414645.6, , Aurelia and European Hospital, ; Rome, Italy
              [355 ]ISNI 0000 0001 2166 6619, GRID grid.9601.e, , Istanbul University Cerrahpasa Medical School, ; Istanbul, Turkey
              [356 ]ISNI 0000 0001 2108 5830, GRID grid.15462.34, , Danube University Krems, ; Krems, Austria
              [357 ]University Hospital St. Poelten, St. Poelten, Austria
              [358 ]GRID grid.412311.4, , Teaching Hospital Policlinico S.Orsola-Malpighi, ; Bologna, Italy
              [359 ]Department of Nephrology, Dialysis, Hypertension, Bologna, Italy
              [360 ]Science and Technology Park for Medicine, Mirandola, Italy
              [361 ]Aferetica, Bologna, Italy
              [362 ]San Marco Hospital, Zingonia, Italy
              [363 ]GRID grid.428484.6, , CytoSorbents, ; Monmouth Junction, USA
              [364 ]Klinikum Emden, Emden, Germany
              [365 ]ISNI 0000 0001 2180 3484, GRID grid.13648.38, , University Hospital Eppendorf, ; Hamburg, Germany
              [366 ]GRID grid.414077.1, , Aurelia Hospital /European Hospital, ; Rome, Italy
              [367 ]ISNI 0000 0004 0594 9821, GRID grid.411556.2, , Fukuoka University hospital, ; Fukuoka, Japan
              [368 ]ISNI 0000 0001 2191 4301, GRID grid.415310.2, , King Faisal Specialist Hospital and Research Center, ; Riyadh, Saudi Arabia
              [369 ]GPR Klinikum Ruesselsheim, Ruesselsheim, Hessen Germany
              [370 ]Hospital O’horan, Mérida, Mexico
              [371 ]ISNI 0000 0001 0661 2073, GRID grid.411898.d, , Jikei University School of Medicine, ; Tokyo, Japan
              [372 ]ISNI 0000 0004 0372 2033, GRID grid.258799.8, , Kyoto University, ; Kyoto, Japan
              [373 ]ISNI 0000 0004 0373 3971, GRID grid.136593.b, , Osaka University, ; Osaka, Japan
              [374 ]GRID grid.420545.2, , Guy’s & St Thomas’ NHS Foundation Trust, ; London, UK
              [375 ]ISNI 0000 0001 2322 6764, GRID grid.13097.3c, , King’s College, ; London, UK
              [376 ]ISNI 0000 0001 2295 9747, GRID grid.411265.5, , Hospital de Santa Maria, ; Lisbon, Portugal
              [377 ]ISNI 000000040459992X, GRID grid.5645.2, , ErasmusMC, ; Rotterdam, Netherlands
              [378 ]ISNI 000000040459992X, GRID grid.5645.2, , ErasmusMC, ; Rotterdam, Netherlands
              [379 ]ISNI 0000 0001 2169 7132, GRID grid.25769.3f, , Gazi University Medical Faculty, ; Ankara, Turkey
              [380 ]Gazi University School of Medicine, Critical Care Fellowship Programme, Ankara, Turkey
              [381 ]ISNI 0000 0001 2169 7132, GRID grid.25769.3f, , Gazi University School of Medicine Biochemistry Department, ; Ankara, Turkey
              [382 ]Fundación Clínica Medica Sur, Mexico City, Mexico
              [383 ]GRID grid.411843.b, , Lund University and Skane University Hospital, ; Lund, Sweden
              [384 ]ISNI 0000 0004 0593 702X, GRID grid.134996.0, , CHU Amiens, ; Amiens, France
              [385 ]ISNI 0000 0004 0444 9382, GRID grid.10417.33, , Radboudumc, ; Nijmegen, Netherlands
              [386 ]ISNI 0000 0001 2348 0746, GRID grid.4989.c, Erasme Hospital, , Université Libre de Bruxelles, ; Brussels, Belgium
              [387 ]ISNI 0000 0004 0417 0648, GRID grid.416224.7, , The Royal Surrey County Hospital, ; Guildford, UK
              [388 ]ISNI 0000 0004 0417 7890, GRID grid.416177.2, , Royal National Orthopaedic Hospital, ; Middlesex, UK
              [389 ]ISNI 0000 0001 0372 5777, GRID grid.139534.9, , Barts Health NHS Trust, ; London, UK
              [390 ]ISNI 0000 0001 2171 1133, GRID grid.4868.2, , Queen Mary University of London, ; London, UK
              [391 ]ISNI 0000 0001 0842 2126, GRID grid.413967.e, , Asan medical center, ; Seoul, South Korea
              [392 ]ISNI 0000 0001 0372 5777, GRID grid.139534.9, , Barts Health NHS Trust, ; London, UK
              [393 ]ISNI 0000 0001 2171 1133, GRID grid.4868.2, , Queen Mary University of London, ; London, UK
              [394 ]ISNI 0000 0004 0571 546X, GRID grid.413548.f, , Hamad medical corporation, ; Doha, Qatar
              [395 ]ISNI 0000 0001 0372 5777, GRID grid.139534.9, , Barts Health NHS Trust, ; London, UK
              [396 ]ISNI 0000 0001 2171 1133, GRID grid.4868.2, , Queen Mary University of London, ; London, UK
              [397 ]ISNI 0000 0001 2342 6459, GRID grid.411693.8, , Trakya Univ, ; Edirne, Turkey
              [398 ]GRID grid.415700.7, General Directorate of Health Services, , Ministry of Health, ; Ankara, Turkey
              [399 ]AnkaraNKARA Research and Training Hospital, Ankara, Turkey
              [400 ]ISNI 0000000109409118, GRID grid.7256.6, Department of Biostatistics, Faculty of Medicine, , Ankara University, ; Ankara, Turkey
              [401 ]ISNI 0000 0004 0642 6432, GRID grid.413783.a, , Ankara Research and Training Hospital, ; Ankara, Turkey
              [402 ]MC Into-Sana, Odessa, Ukraine
              [403 ]ISNI 0000 0000 9831 5916, GRID grid.415564.7, , Glan Clwyd Hospital, ; Rhyl, UK
              [404 ]Fondazione IRCCS Ca’ Granda, Maggiore Policlinico Hospital, Milan, Italy
              [405 ]University of Ferrara, Sant’Anna Hospital, Ferrara, Italy
              [406 ]Aerogen, Galway, Ireland
              [407 ]Kaplan Medical Centre, Rehovot, Israel
              [408 ]ISNI 0000 0001 2156 6140, GRID grid.268154.c, , West Virginia University, ; Morgantown, West Virginia USA
              [409 ]Rihard Knafelj, Ljubljana, Slovenia
              [410 ]GRID grid.7080.f, , Corporació Sanitària i Universitària Parc Taulí, Universitat Autònoma de Barcelona, CIBER Enfermedades Respiratorias, ; Sabadell, Barcelona, Spain
              [411 ]ISNI 0000 0004 1936 8200, GRID grid.55602.34, , Dalhousie University, ; Halifax, Canada
              [412 ]GRID grid.5603.0, , Ernst-Moritz-Arndt-Universität, ; Greifswald, Germany
              [413 ]ISNI 0000 0004 0626 3303, GRID grid.410566.0, , Ghent University Hospital, ; Gent, Belgium
              [414 ]ISNI 0000 0004 1937 0722, GRID grid.11899.38, , Universidade de São Paulo, ; São Paulo, Brazil
              [415 ]ISNI 0000 0000 8970 9163, GRID grid.81821.32, , Hospital La Paz, ; Madrid, Spain
              [416 ]Institute of Mother and Child, Chisinau mun., Moldova
              [417 ]Institute of Emergency Medicine, Chisinau mun., Moldova
              [418 ]State University of Medicine and Pharmacy, Chisinau mun., Moldova
              [419 ]Aerogen, Galway, Ireland
              [420 ]Aerogen, Galway, Ireland
              [421 ]GRID grid.413172.2, , Cardarelli Hospital, ; Naples, Italy
              [422 ]San Paolo Hospital, Naples, Italy
              [423 ]GRID grid.413172.2, , Cardarelli Hospital, ; Naples, Italy
              [424 ]ISNI 0000 0004 0488 0789, GRID grid.6142.1, , National University of Ireland, Galway, ; Galway City, Ireland
              [425 ]ISNI 0000 0004 0473 9881, GRID grid.416166.2, , Mount Sinai Hospital, ; Toronto, Canada
              [426 ]ISNI 0000 0000 9375 4688, GRID grid.414556.7, , Centro Hospitalar São João, ; Porto, Portugal
              [427 ]ISNI 0000 0001 2169 7132, GRID grid.25769.3f, , Gazi University School of Medicine Respiratory Medicine and Critical Care Department, ; Ankara, Turkey
              [428 ]Gazi University School of Medicine, Internal Medicine Critical Care Department, Ankara, Turkey
              [429 ]Gazi University School of Medicine, Geriatrics Department, Ankara, Turkey
              [430 ]ISNI 0000 0001 2169 7132, GRID grid.25769.3f, , Gazi University School of Medicine Respiratory Medicine and Critical Care Department, ; Ankara, Turkey
              [431 ]ISNI 0000 0001 0244 7875, GRID grid.7922.e, , Chulalongkorn University, ; Bangkok, Thailand
              [432 ]GRID grid.471000.2, , Carmel, Lady Davis Medical Center, ; Haifa, Israel
              [433 ]ISNI 0000 0004 1936 7961, GRID grid.26009.3d, , Duke University, ; Durham, USA
              [434 ]ISNI 0000 0004 0459 167X, GRID grid.66875.3a, , Mayo Clinic, ; Rochester, USA
              [435 ]St Helens and Knoowsley, Prescot, UK
              [436 ]ISNI 0000 0001 0709 1919, GRID grid.418716.d, , Royal Infirmary, ; Edinburgh, UK
              [437 ]ISNI 0000 0001 2260 6941, GRID grid.7155.6, , Alexandria Universitry General Hospital, ; Alexandria, Egypt
              [438 ]ISNI 0000 0004 0641 4263, GRID grid.415598.4, , University Hospital North Middlands, ; Stoke On Trent, UK
              [439 ]Mongi Slim University Hospital, La Marsa, Tunisia
              [440 ]GRID grid.414741.3, , Medica Sur, ; Mexico City, Mexico
              [441 ]ISNI 0000 0004 0633 2911, GRID grid.419223.f, , Instituto Nacional de Rehabilitacion, ; Mexico City, Mexico
              [442 ]ISNI 0000 0004 1757 3470, GRID grid.5608.b, , University of Padua, ; Padua, Italy
              [443 ]Sant Antony hospital, Padua, Italy
              [444 ]ISNI 0000 0000 9206 4546, GRID grid.414021.2, , HCMC, ; Minneapolis, USA
              [445 ]ISNI 0000000419368657, GRID grid.17635.36, , University of Minnesota, ; Minneapolis, USA
              [446 ]ISNI 0000 0004 0477 5022, GRID grid.416856.8, , Viecuri Medical Center, ; Venlo, Netherlands
              [447 ]ISNI 0000 0001 2188 0957, GRID grid.410445.0, University of Hawaii, , John A. Burns School of Medicine, ; Honolulu, USA
              [448 ]Respiratory Motion Inc., Waltham, USA
              [449 ]ISNI 0000 0001 2188 0957, GRID grid.410445.0, University of Hawaii, , John A. Burns School of Medicine, ; Honolulu, USA
              [450 ]Respiratory Motion Inc., Waltham, USA
              [451 ]ISNI 0000 0004 0386 9924, GRID grid.32224.35, , Massachusetts General Hospital, ; Boston, USA
              [452 ]ISNI 0000 0001 2188 0957, GRID grid.410445.0, University of Hawaii, , John A. Burns School of Medicine, ; Honolulu, USA
              [453 ]Respiratory Motion Inc., Waltham, USA
              [454 ]ISNI 0000 0004 0386 9924, GRID grid.32224.35, , Massachusetts General Hospital, ; Boston, USA
              [455 ]AO Desio e Vimercate, Vimercate, Italy
              [456 ]AO Crema, Crema, Italy
              [457 ]ISNI 0000 0001 2174 1754, GRID grid.7563.7, , University of Milan-Bicocca, ; Monza, Italy
              [458 ]ISNI 0000 0000 9206 2401, GRID grid.267308.8, , UT Health Science Center at Houston, ; Houston, TX USA
              [459 ]ISNI 0000 0001 2188 0957, GRID grid.410445.0, University of Hawaii, , John A. Burns School of Medicine, ; Honolulu, HI USA
              [460 ]Respiratory Motion Inc., Waltham, MA USA
              [461 ]ISNI 0000 0004 0386 9924, GRID grid.32224.35, , Massachusetts General Hospital, ; Boston, MA USA
              [462 ]Swisstom AG, Landquart, Switzerland
              [463 ]ISNI 0000 0000 9024 6397, GRID grid.412581.b, Kliniken der Stadt Köln, Pneumology and Critical Care Medicine, , Witten / Herdecke University, ; Ostmerheimer Str. 200, 51109 Cologne, Germany
              [464 ]Swisstom AG, Landquart, Switzerland
              [465 ]ISNI 0000 0000 9024 6397, GRID grid.412581.b, Kliniken der Stadt Köln, Pneumology and Critical Care Medicine, , Witten/ Herdecke University, ; Ostmerheimer Str. 200, 51109 Cologne, Germany
              [466 ]ARDS and ECMO Center Köln-Merheim, Cologne, Germany
              [467 ]Swisstom, Chur, Switzerland
              [468 ]ISNI 000000009445082X, GRID grid.1649.a, , Sahlgrenska Univ Hospital, ; Göteborg, Sweden
              [469 ]ISNI 0000 0001 2200 8888, GRID grid.9841.4, , Second University of Naples, ; Naples, Italy
              [470 ]San Paolo Hospital, Naples, Italy
              [471 ]ISNI 0000 0001 2097 9138, GRID grid.11450.31, , University of Sassari, ; Sassari, Italy
              [472 ]GRID grid.413172.2, , Cardarelli Hospital, ; Naples, Italy
              [473 ]University of Saerno, Salerno, Italy
              [474 ]East Surrey Hospital, Surrey and Sussex NHS Trust, Surrey, UK
              [475 ]ISNI 0000 0004 0473 9881, GRID grid.416166.2, , Mount Sinai Hospital and University of Toronto, ; Toronto, Canada
              [476 ]ISNI 0000 0001 0661 1177, GRID grid.417184.f, , University Health Network-Toronto General Hospital and Univeristy of Toronto, ; Toronto, Canada
              [477 ]ISNI 0000000121885934, GRID grid.5335.0, , University of Cambridge, ; Cambridge, UK
              [478 ]ISNI 0000 0004 0399 2308, GRID grid.417155.3, , Papworth Hospital, ; Cambridge, UK
              [479 ]ISNI 0000 0004 0489 4320, GRID grid.429705.d, , King’s College Hospital NHS Foundation Trust, ; London, UK
              [480 ]Meijer Heart & Vascular Institute, Grand Rapids, USA
              [481 ]ISNI 0000 0004 0648 9396, GRID grid.416025.4, Glenfield Hospital, , UHL, ; Leicester, UK
              [482 ]ISNI 0000 0004 0621 9599, GRID grid.412106.0, , National University Hospital, ; Singapore, Singapore
              [483 ]ISNI 0000 0001 2180 6431, GRID grid.4280.e, , National University Singapore, ; Singapore, Singapore
              [484 ]ISNI 0000 0000 8875 6339, GRID grid.417468.8, , Mayo Clinic, ; Phoenix, AZ USA
              [485 ]ISNI 0000 0004 1936 9000, GRID grid.21925.3d, , University of Pittsburgh, ; Pittsburgh, PA USA
              [486 ]ISNI 0000 0001 0675 8654, GRID grid.411083.f, , Vall D’Hebron University Hospital, ; Barcelona, Spain
              [487 ]GRID grid.7080.f, , Universitat Autonoma de Barcelona, ; Barcelona, Spain
              [488 ]V.A. Negovsky Research Institute of General Reanimatology, Moscow, Russia
              [489 ]NN Burdenko Main Military Hospital, Moscow, Russia
              [490 ]George P. Livanos and Marianthi Simou Laboratories, Athens, Greece
              [491 ]ISNI 0000 0004 0576 5395, GRID grid.11047.33, , University of Patras, ; Rio, Achaia Greece
              [492 ]ISNI 0000 0004 1757 2064, GRID grid.8484.0, , University of Ferrara, ; Ferrara, Italy
              [493 ]ISNI 0000 0001 0120 3326, GRID grid.7644.1, , University of Bari, ; Bari, Italy
              [494 ]CHU HJRA, Antananarivo, Madagascar
              [495 ]ISNI 0000 0004 0593 702X, GRID grid.134996.0, Réanimation médicale, , Centre Hospitalier Universitaire, ; Amiens, France
              [496 ]ISNI 0000 0004 1937 0722, GRID grid.11899.38, Cardio-Pulmonary Department, Pulmonary Division, , Heart Institute (Incor), University of São Paulo, ; São Paulo, Brazil
              [497 ]ISNI 0000 0004 0593 702X, GRID grid.134996.0, , CHU Amiens, ; Amiens, France
              [498 ]GRID grid.439338.6, , Royal Brompton Hospital, ; London, UK
              [499 ]ISNI 0000 0000 9887 307X, GRID grid.416332.1, , Musashino Red Cross Hospital, ; Tokyo, Japan
              [500 ]JSEPTIC Clinical Trial Group, Tokyo, Japan
              [501 ]ISNI 0000 0004 0392 7039, GRID grid.418340.a, , Centro Hospitalar do Porto, ; Porto, Portugal
              [502 ]ISNI 0000 0004 1936 8470, GRID grid.10025.36, , University of Liverpool, ; Liverpool, UK
              [503 ]ISNI 0000 0004 0417 2395, GRID grid.415970.e, , Royal Liverpool University Hospital, ; Liverpool, UK
              [504 ]Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi County, Taiwan
              [505 ]ISNI 0000 0000 8816 6945, GRID grid.411048.8, , Hospital Clínico Universitario de Santiago de Compostela, ; Santiago de Compostela, Spain
              [506 ]GRID grid.412966.e, , MUMC, ; Maastricht, Netherlands
              [507 ]ISNI 0000 0004 0417 2395, GRID grid.415970.e, , Royal Liverpool University Hospital, ; Liverpool, UK
              [508 ]ISNI 0000 0004 0567 3159, GRID grid.426597.b, , Vilnius University Hospital Santariskiu Clinics, ; Vilnius, Lithuania
              [509 ]Vilnius University, Faculty of Medicine, Vilnius, Lithuania
              [510 ]ISNI 0000 0004 0575 9497, GRID grid.411785.e, , Mercy University Hospital, ; Cork, Ireland
              [511 ]Hospital Meridional S.A., Cariacica, Brazil
              [512 ]ISNI 0000 0001 0721 9812, GRID grid.150338.c, , Geneva Universtiy Hospital, ; Geneva, Switzerland
              [513 ]ISNI 0000 0000 8704 3732, GRID grid.413357.7, Medical University Department, , Kantonsspital Aarau, ; Aarau, Switzerland
              [514 ]ISNI 0000 0004 0479 0855, GRID grid.411656.1, Department of Endocrinology, Diabetes and Clinical Nutrition, , University Hospital Bern, ; Bern, Switzerland
              [515 ]ISNI 0000 0004 0578 1096, GRID grid.414977.8, , Jessa Ziekenhuis, ; Hasselt, Belgium
              [516 ]ISNI 0000 0004 0392 7039, GRID grid.418340.a, , Centro Hospitalar do Porto, ; Porto, Portugal
              [517 ]Unidade Local de Saude do Alto Minho, Viana do Castelo, Portugal
              [518 ]Unidade de Saude Local de Castelo Branco, Castelo Branco, Portugal
              [519 ]ISNI 0000000106861985, GRID grid.28911.33, , Centro Hospitalar e Universitario de Coimbra, ; Coimbra, Portugal
              [520 ]ISNI 0000 0000 8902 4519, GRID grid.418336.b, , Centro Hospitalar de Vila Nova de Gaia, ; Vila Nova de Gaia, Portugal
              [521 ]Centro Hospitalar do Algarve, Faro, Portugal
              [522 ]GRID grid.435544.7, , Instituto Portugues de Oncologia do Porto, ; Porto, Portugal
              [523 ]ISNI 0000 0001 1503 7226, GRID grid.5808.5, , Faculdade de Ciencias da Nutricao e Alimentacao da Universidade do Porto, ; Porto, Portugal
              [524 ]ISNI 0000 0004 0392 7039, GRID grid.418340.a, , Centro Hospitalar do Porto, ; Porto, Portugal
              [525 ]ISNI 0000 0001 1503 7226, GRID grid.5808.5, , Faculdade de Ciencias da Nutrição e Alimentação da Universidade do Porto, ; Porto, Portugal
              [526 ]GRID grid.466592.a, , Centro Hospitalar Tamega e Sousa, ; Penafiel, Portugal
              [527 ]ISNI 0000 0004 0631 0608, GRID grid.418711.a, , Instituto Português de Oncologia do Porto, ; Porto, Portugal
              [528 ]Unidade Local de Saude do Alto Minho, Viana do Castelo, Portugal
              [529 ]ISNI 0000000106861985, GRID grid.28911.33, , Centro Hospitalar e Universitário de Coimbra, ; Coimbra, Portugal
              [530 ]Unidade de Saude Local de Castelo Branco, Castelo Branco, Portugal
              [531 ]Centro Hospitalar do Algarve, Faro, Portugal
              [532 ]Centro Hospitalar do Baixo Vouga, Aveiro, Portugal
              [533 ]ISNI 0000 0000 8902 4519, GRID grid.418336.b, , Centro Hospitalar de Vila Nova de Gaia, ; Vila Nova de Gaia, Portugal
              [534 ]ISNI 0000 0001 0440 1889, GRID grid.240404.6, , Nottingham University Hospital NHS Trust, ; Nottingham, UK
              [535 ]ISNI 0000 0004 0470 1162, GRID grid.7130.5, , Prince of Songkla University, ; Songkla, Thailand
              [536 ]ISNI 0000 0000 8704 3732, GRID grid.413357.7, , Kantonsspital Aarau, ; Aarau, Switzerland
              [537 ]ISNI 0000 0000 9064 6198, GRID grid.86715.3d, , Université de Sherbrooke, ; Sherbrooke, Canada
              [538 ]University Hospital, Montevideo, Uruguay
              [539 ]Bucharest Clinical Emergency Hospital, Bucharest, Romania
              [540 ]ISNI 0000 0004 0540 9980, GRID grid.415180.9, , Fundeni Clinical Institute, ; Bucharest, Romania
              [541 ]University Hospital, Montevideo, Uruguay
              [542 ]ISNI 0000 0000 9064 6198, GRID grid.86715.3d, , Université de Sherbrooke, ; Sherbrooke, Canada
              [543 ]ISNI 0000 0004 1936 8331, GRID grid.410356.5, , Queen’s University, ; Kingston, Canada
              [544 ]ISNI 0000 0004 0646 2097, GRID grid.412468.d, , University Medical Center Schleswig-Holstein, ; Kiel, Germany
              [545 ]ISNI 0000 0001 1939 2794, GRID grid.9613.d, , University of Jena, ; Jena, Germany
              [546 ]ISNI 0000 0000 9064 6198, GRID grid.86715.3d, , Université de Sherbrooke, ; Sherbrooke, Canada
              [547 ]ISNI 0000 0004 1936 8331, GRID grid.410356.5, , Queen’s University, ; Kingston, Canada
              [548 ]University Hospital, Montevideo, Uruguay
              [549 ]Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi County, Taiwan
              [550 ]ISNI 0000 0004 0392 7039, GRID grid.418340.a, , Centro Hospitalar do Porto, ; Porto, Portugal
              [551 ]Aida Hospital, Fukushima, Japan
              [552 ]Keiyo Hospital, Tokyo, Japan
              [553 ]Shisei Hospital, Saitama, Japan
              [554 ]ISNI 0000 0004 0470 1162, GRID grid.7130.5, , Prince of Songkla University, ; Hat Yai City, Songkhla Province Thailand
              [555 ]ISNI 0000 0004 0392 7039, GRID grid.418340.a, , Centro Hospitalar do Porto, ; Porto, Portugal
              [556 ]ISNI 0000 0001 1503 7226, GRID grid.5808.5, , Faculdade de Ciencias da Nutrição e Alimentação da Universidade do Porto, ; Porto, Portugal
              [557 ]GRID grid.466592.a, , Centro Hospitalar Tamega e Sousa, ; Penafiel, Portugal
              [558 ]ISNI 0000000106861985, GRID grid.28911.33, , Centro Hospitalar e Universitário de Coimbra, ; Coimbra, Portugal
              [559 ]ISNI 0000 0004 0631 0608, GRID grid.418711.a, , Instituto Português de Oncologia do Porto, ; Porto, Portugal
              [560 ]Unidade Local de Saude do Alto Minho, Viana do Castelo, Portugal
              [561 ]Centro Hospitalar Baixo Vouga, Aveiro, Portugal
              [562 ]Unidade de Saude Local de Castelo Branco, Castelo Branco, Portugal
              [563 ]Centro Hospitalar do Algarve, Faro, Portugal
              [564 ]ISNI 0000 0000 8902 4519, GRID grid.418336.b, , Centro Hospitalar de Vila Nova de Gaia, ; Vila Nova de Gaia, Portugal
              [565 ]ISNI 0000 0004 0576 574X, GRID grid.415248.e, Department of Cardiothoracic Surgery, , George Papanikolaou General Hospital, ; Thessaloniki, Greece
              [566 ]ISNI 0000 0001 0720 6034, GRID grid.413460.4, , Gülhane Military Medical Academy, ; Ankara, Turkey
              [567 ]GRID grid.461837.f, , Ankara Mevki Military Hospital, ; Ankara, Turkey
              [568 ]ISNI 0000 0000 9244 0345, GRID grid.416353.6, , St Bartholomew’s Hospital, ; London, UK
              [569 ]Aristotle Medical School, Thessaloniki, Greece
              [570 ]ISNI 0000 0001 0663 3325, GRID grid.410793.8, , Tokyo Medical University Hachiosi Medical Center, ; Tokyo, Japan
              [571 ]ISNI 0000 0001 0273 556X, GRID grid.414205.6, , Hôpital Louis Mourier, ; Colombes, France
              [572 ]Laboratoire ILUMENS, Paris, France
              [573 ]Institut de Hauts de Seine, Nanterre, France
              [574 ]GRID grid.439787.6, , University Hospital Lewisham, ; London, UK
              [575 ]GRID grid.439484.6, , Queen Elizabeth Hospital, ; London, UK
              [576 ]Minet Green Health Practice, London, UK
              [577 ]ISNI 0000 0001 0805 7253, GRID grid.4861.b, Department of Public Health, , University of Liège, ; Liège, Belgium
              [578 ]ISNI 0000 0000 8607 6858, GRID grid.411374.4, Department of Emergency Medicine, , University Hospital of Liège, ; Liège, Belgium
              [579 ]ISNI 0000 0001 0805 7253, GRID grid.4861.b, Department of Medical Biostatistics, , University of Liège, ; Liège, Belgium
              [580 ]ISNI 0000 0004 1936 9756, GRID grid.10253.35, University Hospital, , Philipps University Marburg, ; Marburg, Germany
              [581 ]ISNI 0000 0001 0244 7875, GRID grid.7922.e, , Chulalongkorn University, ; Bangkok, Thailand
              [582 ]ISNI 0000 0004 0389 8485, GRID grid.55325.34, , Oslo University Hospital, ; Oslo, Norway
              [583 ]ISNI 0000 0004 0398 7998, GRID grid.417122.3, , William Harvey Hospital, ; Ashford, UK
              [584 ]GRID grid.410783.9, , Kansai Medical University Takii Hospital, ; Moriguchi, Japan
              [585 ]Aristotle Medical School, Thessaloniki, Greece
              [586 ]ISNI 0000 0004 1762 2623, GRID grid.410775.0, , Japanese Red Cross Musashino Hospital, ; Tokyo, Japan
              [587 ]ISNI 0000000404654431, GRID grid.5650.6, , Academic Medical Center, ; Amsterdam, Netherlands
              [588 ]ISNI 0000 0004 0399 8347, GRID grid.415214.7, , Medisch Spectrum Twente, ; Enschede, Netherlands
              [589 ]ISNI 0000000121697570, GRID grid.7548.e, , University Modena, ; Modena, Italy
              [590 ]Nuovo Ospedale Civile Sant’Agostino Estense, Modena, Italy
              [591 ]ISNI 0000 0001 2260 6941, GRID grid.7155.6, , Faculty of Medicine Alexandria University, ; Alexandria, Egypt
              [592 ]ISNI 0000 0004 0624 9667, GRID grid.416854.a, , Victoria Hospital, ; Kirkcaldy, UK
              [593 ]ISNI 0000 0004 0612 7379, GRID grid.470040.7, , Ziekenhuis Oost-Limburg, ; Genk, Belgium
              [594 ]ISNI 0000 0001 0244 7875, GRID grid.7922.e, , Chulalongkorn University, ; Bangkok, Thailand
              [595 ]ISNI 0000 0000 9984 5644, GRID grid.413314.0, , The Canberra Hospital, ; Hughes, ACT Australia
              [596 ]ISNI 0000 0001 2180 7477, GRID grid.1001.0, , ANU Medical School, ; Canberra, Australia
              [597 ]GRID grid.416240.5, , “Spirito Santo” Hospital, ; Pescara, Italy
              [598 ]GRID grid.430395.8, , St Lukes International Hospital, ; Akashi-Chou Chuo-Ku, Japan
              [599 ]ISNI 0000 0001 0707 9039, GRID grid.412010.6, , Kangwon National University, ; Chuncheonsi, South Korea
              [600 ]ISNI 0000 0004 0621 0228, GRID grid.413126.3, , Military Medical Academy, ; Sofia, Bulgaria
              [601 ]ISNI 0000 0001 0707 9039, GRID grid.412010.6, , Kangwon National University, ; Chuncheonsi, South Korea
              [602 ]ISNI 0000 0001 0707 9039, GRID grid.412010.6, , Kangwon National University, ; Chuncheonsi, South Korea
              [603 ]Nuovo Ospedale Civile Sant’Agostino Estense, Modena, Italy
              [604 ]ISNI 0000000121697570, GRID grid.7548.e, , University Modena, ; Modena, Italy
              [605 ]Istanbul University, Medical Faculty of Istanbul, Anesthesiology and Intensive Care, Istanbul, Turkey
              [606 ]ISNI 0000 0001 2166 6619, GRID grid.9601.e, , Istanbul University, Medical Faculty of Istanbul, Department of Neuroradiology, ; Istanbul, Turkey
              [607 ]ISNI 0000 0001 2166 6619, GRID grid.9601.e, , Istanbul University, Institute of Experimental Medicine, Neuroscience, ; Istanbul, Turkey
              [608 ]Bucharest Clinical Emergency Hospital, Bucharest, Romania
              [609 ]ISNI 0000 0004 0540 9980, GRID grid.415180.9, , Fundeni Clinical Institute, ; Bucharest, Romania
              [610 ]ISNI 0000000404654431, GRID grid.5650.6, , Academic Medical Center, ; Amsterdam, Netherlands
              [611 ]ISNI 0000 0004 0399 8347, GRID grid.415214.7, , Medisch Spectrum Twente, ; Enschede, Netherlands
              [612 ]ISNI 0000 0000 9950 5666, GRID grid.15485.3d, , Helsinki University Hospital, ; Helsinki, Finland
              [613 ]ISNI 0000 0004 0368 0478, GRID grid.416446.5, , North Karelia Central Hospital, ; Joensuu, Finland
              [614 ]ISNI 0000 0004 0628 207X, GRID grid.410705.7, , Kuopio University Hospital, ; Kuopio, Finland
              [615 ]ISNI 0000 0004 0391 9020, GRID grid.46699.34, , King’s College Hospital, ; London, UK
              [616 ]ISNI 0000 0004 1771 1175, GRID grid.411342.1, , Hospital Universitario Puerta del Mar, ; Cadiz, Spain
              [617 ]ISNI 0000 0004 1771 0842, GRID grid.411319.f, , Hospital Infanta Cristina, ; Badajoz, Spain
              [618 ]ISNI 0000 0000 9606 5108, GRID grid.412687.e, , The Ottawa Hospital, ; Ottawa, Canada
              [619 ]Ulaval, Quebec City, Canada
              [620 ]ISNI 0000 0001 2288 9830, GRID grid.17091.3e, , UBC, ; Vancouver, Canada
              [621 ]UManitoba, Winnipeg, Canada
              [622 ]OHRI, Ottawa, Canada
              [623 ]ISNI 0000 0000 9606 5108, GRID grid.412687.e, , The Ottawa Hospital, ; Ottawa, Canada
              [624 ]Ulaval, Quebec City, Canada
              [625 ]ISNI 0000 0001 2288 9830, GRID grid.17091.3e, , UBC, ; Vancouver, Canada
              [626 ]UManitoba, Winnipeg, Canada
              [627 ]ISNI 0000 0000 9606 5108, GRID grid.412687.e, , Ottawa Hospital Research Institute, ; Ottawa, Canada
              [628 ]ISNI 0000 0001 2294 713X, GRID grid.7942.8, Cliniques St Luc, , Université catholique de Louvain, ; Brussels, Belgium
              [629 ]ISNI 0000 0004 1757 8749, GRID grid.414818.0, , Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, ; Milan, Italy
              [630 ]ISNI 0000 0004 1757 2822, GRID grid.4708.b, , Milan University, ; Milan, Italy
              [631 ]ISNI 0000 0001 0423 4662, GRID grid.8515.9, , CHUV, ; Lausanne, Switzerland
              [632 ]ISNI 0000 0001 2322 4179, GRID grid.410528.a, , CHU de Nice, ; Nice, France
              [633 ]ISNI 0000 0004 1771 0842, GRID grid.411319.f, , Hospital Infanta Cristina, ; Badajoz, Spain
              [634 ]ISNI 0000 0004 1771 1175, GRID grid.411342.1, , Hospital Universitario Puerta del Mar, ; Cadiz, Spain
              [635 ]ISNI 0000 0004 0609 0449, GRID grid.447961.9, , Regional Hospital, ; Liberec, Czech Republic
              [636 ]ISNI 0000 0004 0404 6946, GRID grid.424967.a, , Institute of Experimental Medicine, ; Prague, Czech Republic
              [637 ]ISNI 0000 0000 9206 4546, GRID grid.414021.2, , Hennepin County Medical Center, ; Minneapolis, USA
              [638 ]ISNI 0000 0001 2193 314X, GRID grid.8756.c, , University of Glasgow, ; Glasgow, UK
              [639 ]ISNI 0000 0001 0523 9342, GRID grid.413301.4, Institute of Neurological Sciences, , NHSGGC, ; Glasgow, UK
              [640 ]ISNI 0000 0001 0523 9342, GRID grid.413301.4, Department of Clinical Physics and Bioengineering, , NHSGGC, ; Glasgow, UK
              [641 ]ISNI 0000 0001 2193 314X, GRID grid.8756.c, Academic Unit of Anaesthesia, Pain and Critical Care Medicine, , University of Glasgow, ; Glasgow, UK
              [642 ]Smartimplant Ltd., Tallinn, Estonia
              [643 ]ISNI 0000 0004 0631 377X, GRID grid.454953.a, , NEMC, ; Tallinn, Estonia
              [644 ]ISNI 0000 0004 1936 8390, GRID grid.23856.3a, , Universite Laval, ; Quebec, Canada
              [645 ]ISNI 0000 0004 1936 9609, GRID grid.21613.37, , University of Manitoba, ; Winnipeg, Canada
              [646 ]ISNI 0000 0000 9606 5108, GRID grid.412687.e, , Ottawa Hospital Research Institute, ; Ottawa, Canada
              [647 ]ISNI 0000 0001 2292 3357, GRID grid.14848.31, , Universite de Montreal, ; Montreal, Canada
              [648 ]ISNI 0000 0001 2288 9830, GRID grid.17091.3e, , University of British Columbia, ; Vancouver, Canada
              [649 ]ISNI 0000 0004 1936 8390, GRID grid.23856.3a, , Universite Laval, ; Quebec, Canada
              [650 ]ISNI 0000 0004 1936 8200, GRID grid.55602.34, , Dalhousie University, ; Halifax, Canada
              [651 ]ISNI 0000 0000 9606 5108, GRID grid.412687.e, , Ottawa Hospital Research Institute, ; Ottawa, Canada
              [652 ]ISNI 0000 0004 1936 9609, GRID grid.21613.37, , University of Manitoba, ; Winnipeg, Canada
              [653 ]ISNI 0000 0001 2292 3357, GRID grid.14848.31, , Universite de Montreal, ; Montreal, Canada
              [654 ]ISNI 0000 0001 2288 9830, GRID grid.17091.3e, , University of British Columbia, ; Vancouver, Canada
              [655 ]Hospital Estadual Getulio Vargas, Rio de Janeiro, Brazil
              [656 ]ISNI 0000 0004 0470 5454, GRID grid.15444.30, , Yonsei University College of Medicine, ; Seoul, South Korea
              [657 ]ISNI 0000 0000 8704 3732, GRID grid.413357.7, , Kantonsspital Aarau, ; Aarau, Switzerland
              [658 ]ISNI 0000 0001 2150 9058, GRID grid.411439.a, Emergency Department, , Groupe Hospitalier Pitié-Salpêtrière, ; Paris, France
              [659 ]ISNI 0000 0000 8602 0133, GRID grid.416123.3, , Morton Plant Hospital, ; Clearwater, USA
              [660 ]ISNI 0000 0000 8704 3732, GRID grid.413357.7, Department of Laboratory Medicine, , Kantonsspital Aarau, ; Aarau, Switzerland
              [661 ]ISNI 0000 0004 0474 4488, GRID grid.412944.e, , Royal Cornwall Hospital Trust, ; Truro, UK
              [662 ]ISNI 0000 0004 0641 2823, GRID grid.419319.7, , Manchester Royal Infirmary, ; Manchester, UK
              [663 ]ISNI 0000 0004 0571 546X, GRID grid.413548.f, , Hamad Medical Corporation, ; Doha, Qatar
              [664 ]ISNI 0000 0004 1764 0856, GRID grid.417324.7, University of Tsukuba, , Tsukuba Medical Center Hospital, ; Tsukuba, Japan
              [665 ]ISNI 0000 0004 0391 9020, GRID grid.46699.34, , King’s College Hospital, ; London, UK
              [666 ]Kent, Surrey & Sussex Air Ambulance Trust, Kent, UK
              [667 ]Prometheus Delta-Tech, Herefordshire, UK
              [668 ]ISNI 0000 0004 0391 9020, GRID grid.46699.34, , King’s College Hospital, ; London, UK
              [669 ]ISNI 0000 0004 0627 2891, GRID grid.412835.9, , Stavanger University Hospital, ; Stavanger, Norway
              [670 ]ISNI 0000 0004 0417 0728, GRID grid.416091.b, , Royal United Hospital, ; Bath, UK
              [671 ]ISNI 0000 0004 0607 7156, GRID grid.413974.c, , Aseer Central Hospital, ; Abha, Saudi Arabia
              [672 ]ISNI 0000 0004 0608 0662, GRID grid.412149.b, , King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, ; Riyadh, Saudi Arabia
              [673 ]ISNI 0000 0004 0593 1832, GRID grid.415277.2, , King Fahad Medical City, ; Riyadh, Saudi Arabia
              [674 ]ISNI 0000 0004 0568 6689, GRID grid.413591.b, , HagaZiekenhuis, ; Den Haag, Netherlands
              [675 ]ISNI 0000 0004 0624 5690, GRID grid.415868.6, , Reinier de Graaf Gasthuis, ; Delft, Netherlands
              [676 ]GRID grid.411600.2, Toxicological Research Center, Department of Clinical Toxicology, , Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, ; Tehran, Iran
              [677 ]ISNI 0000 0001 2295 9747, GRID grid.411265.5, , Santa Maria University Hospital, ; Lisboa, Portugal
              [678 ]ISNI 0000 0001 0315 8143, GRID grid.412751.4, , St. Vincent’s University Hospital, ; Dublin 4, Ireland
              [679 ]Percy Military Teaching Hospital, Clamart, France
              [680 ]ISNI 0000 0004 0417 1894, GRID grid.417083.9, , Whiston Hospital, ; Prescot, UK
              [681 ]ISNI 0000 0000 9825 7840, GRID grid.411714.6, , Glasgow Royal Infirmary, ; Glasgow, UK
              [682 ]ISNI 0000 0004 1790 7311, GRID grid.415254.3, , King Abdulaziz Medical City, National Guard Hospital, ; Riyadh, Saudi Arabia
              [683 ]ISNI 0000 0004 1773 5396, GRID grid.56302.32, Department of Management, College of Business Administration, , King Saud University, Saudi Arabia, ; Riyadh, Saudi Arabia
              [684 ]ISNI 0000 0004 0608 0662, GRID grid.412149.b, , King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, ; Riyadh, Saudi Arabia
              [685 ]ISNI 0000 0004 0535 6364, GRID grid.412190.f, , Ege University Hospital, ; Izmir, Turkey
              [686 ]Katip Celebi University, Health Sciences Faculty, Izmir, Turkey
              [687 ]GRID grid.415667.7, , Milton Keynes University Hospital NHS Foundation Trust, ; Milton Keynes, UK
              [688 ]ISNI 0000 0004 1937 0490, GRID grid.10223.32, Faculty of Pharmacy, , Mahidol University, ; Bangkok, Thailand
              [689 ]ISNI 0000 0004 1937 0490, GRID grid.10223.32, Faculty of Medicine, Ramathibodi Hospital, , Mahidol University, ; Bangkok, Thailand
              [690 ]Specialist Anesthesia, Doha, Qatar
              [691 ]Xanthi General Hospital, Xanthi, Greece
              [692 ]ISNI 0000 0004 0417 0728, GRID grid.416091.b, , Royal United Hospital, ; Bath, UK
              [693 ]ISNI 0000 0001 2179 1970, GRID grid.21006.35, , University of Canterbury, ; Christchurch, New Zealand
              [694 ]ISNI 0000 0004 0614 1349, GRID grid.414299.3, , Christchurch Hospital, ; Christchurch, New Zealand
              [695 ]Rihard Knafelj, Ljubljana, Slovenia
              [696 ]ISNI 0000 0004 0571 7705, GRID grid.29524.38, , Clinical Center Ljubljana, ; Ljubljana, Slovenia
              [697 ]ISNI 0000 0004 0417 0461, GRID grid.424926.f, , The Royal Marsden Hospital, ; London, UK
              [698 ]GRID grid.412081.e, , Bogomolets National Medical University, ; Kiev, Ukraine
              [699 ]Aristotle Medical School, Thessaloniki, Greece
              [700 ]Royal Liverpool Intensive Care Unit, Liverpool, UK
              [701 ]ISNI 0000 0004 1936 8470, GRID grid.10025.36, , University of Liverpool, ; Liverpool, UK
              [702 ]GRID grid.439591.3, , Homerton University Hospital, ; London, UK
              [703 ]ISNI 0000 0004 1937 0722, GRID grid.11899.38, , University of Sao Paulo, ; Sao Paulo, Brazil
              [704 ]ISNI 0000 0004 1936 8411, GRID grid.9918.9, , University of Leicester, ; Leicester, UK
              [705 ]ISNI 0000 0004 0391 9020, GRID grid.46699.34, , King’s College Hospital, ; London, UK
              [706 ]Research and Education Institute, Sao Paulo, Brazil
              [707 ]ISNI 0000 0004 0391 9020, GRID grid.46699.34, , King’s College Hospital, ; London, UK
              [708 ]ISNI 0000 0004 0413 7370, GRID grid.412930.d, , Ipswich Hospital NHS Trust, England, UK, ; Ipswich, UK
              [709 ]ISNI 0000 0004 0576 1212, GRID grid.414965.b, , Phramongkutklao Hospital, ; Bangkok, Thailand
              [710 ]ISNI 0000 0004 1937 0490, GRID grid.10223.32, , Phramongkutklao College of Medicine, ; Bangkok, Thailand
              [711 ]ISNI 0000 0000 8704 3732, GRID grid.413357.7, , Kantonsspital Aarau, ; Aarau, Switzerland
              [712 ]ISNI 0000 0000 8611 7824, GRID grid.412588.2, , Pusan National University Hospital, ; Busan, South Korea
              [713 ]ISNI 0000 0004 0417 2395, GRID grid.415970.e, , Royal Liverpool University Hospital, ; Liverpool, UK
              [714 ]ISNI 0000 0004 1936 8470, GRID grid.10025.36, , University of Liverpool, ; Liverpool, UK
              [715 ]ISNI 0000 0004 0621 2899, GRID grid.414122.0, PICU, , Hippokration General Hospital, ; Thessaloniki, Greece
              [716 ]ISNI 0000 0001 2191 4301, GRID grid.415310.2, , King Faisal Specialist Hospital & Research Centre, ; Riyadh, Saudi Arabia
              [717 ]ISNI 0000 0001 0661 2073, GRID grid.411898.d, , The Jikei University School of Medicine, ; Tokyo, Japan
              [718 ]Albert Schweitzer State Hospital, Rio de Janeiro, Brazil
              [719 ]ISNI 0000 0001 2294 473X, GRID grid.8536.8, PPG Internal Medicine, , Federal University of Rio de Janeiro, ; Rio de Janeiro, Brazil
              [720 ]Hospital Esperanca Recife, Recife, Brazil
              [721 ]Hospital Total Cor, Rio de Janeiro, Brazil
              [722 ]Hospital viValle, São José dos Campos, Brazil
              [723 ]Hospital Rios DOr, Rio de Janeiro, Brazil
              [724 ]Hospital Norte DOr, Rio de Janeiro, Brazil
              [725 ]Hospital Esperanca Olinda, Olinda, Brazil
              [726 ]GRID grid.472984.4, , DOr Institute for Research and Education - IDOR, ; Rio de Janeiro, Brazil
              [727 ]ISNI 0000 0004 0377 0318, GRID grid.416984.6, , Stamford Hospital, ; Stamford, USA
              [728 ]ISNI 0000 0004 0398 7314, GRID grid.413475.0, , Darent Valley Hospital, ; Dartford, UK
              [729 ]ISNI 0000 0004 0398 7998, GRID grid.417122.3, , William Harvey Hospital, ; Ashford, UK
              [730 ]GRID grid.443984.6, , St James’s University Hospital, ; Leeds, UK
              [731 ]GRID grid.414794.b, , Hospital Maciel, ; Montevideo, Uruguay
              [732 ]GRID grid.472984.4, , DOr Institute for Research and Education - IDOR, ; Rio de Janeiro, Brazil
              [733 ]ISNI 0000 0004 0615 7498, GRID grid.427783.d, , Hospital de Cancer de Barretos, ; Barretos, Brazil
              [734 ]ISNI 0000 0000 9080 8521, GRID grid.413471.4, , Hospital Sírio Libanês, ; Sao Paulo, Brazil
              [735 ]Sta. Casa de Porto Alegre, Porto Alegre, Brazil
              [736 ]ISNI 0000 0001 0650 7433, GRID grid.412689.0, , University of Pittsburgh Medical Center, ; Pittsburgh, USA
              [737 ]Hospital Sao Lucas, Rio de Janeiro, Brazil
              [738 ]Hospital Meridional S.A., Cariacica, Brazil
              [739 ]GRID grid.419135.b, , Sheffield Teaching Hospitals, ; Sheffield, UK
              [740 ]ISNI 0000 0004 0417 1894, GRID grid.417083.9, , Whiston Hospital, ; St Helens & Knowsley, UK
              [741 ]ISNI 0000000106861985, GRID grid.28911.33, , Centro Hospitalar e Universitário de Coimbra, ; Coimbra, Portugal
              [742 ]ISNI 0000 0004 0631 0608, GRID grid.418711.a, , Instituto Português de Oncologia Francisco Gil - Porto, ; Porto, Portugal
              [743 ]ISNI 0000 0004 0608 0662, GRID grid.412149.b, , King Saud bin Abdulaziz University for Health Sciences, ; Riyadh, Saudi Arabia
              [744 ]ISNI 0000 0001 0273 556X, GRID grid.414205.6, , Hôpital Louis Mourier, ; Colombes, France
              [745 ]ISNI 0000 0000 8588 831X, GRID grid.411119.d, , Hôpital Bichat, ; Paris, France
              [746 ]ISNI 0000 0004 0649 0266, GRID grid.416122.2, , Morriston Hospital, ; Swansea, UK
              [747 ]ISNI 0000 0000 8959 0182, GRID grid.419728.1, , Abertawe Bro Morgannwg University Health Board, ; Swansea, UK
              [748 ]ISNI 0000 0004 0392 7039, GRID grid.418340.a, , Centro Hospitalar Porto, ; Porto, Portugal
              [749 ]Rihard Knafelj, Ljubljana, Slovenia
              [750 ]ISNI 0000 0004 1802 3550, GRID grid.413839.4, , Apollo Speciality Hospital - OMR, ; Chennai, India
              [751 ]Hospital Meridional S.A., Cariacica, Brazil
              [752 ]Rihard Knafelj, Ljubljana, Slovenia
              [753 ]ISNI 0000 0000 9606 5108, GRID grid.412687.e, , The Ottawa Hospital, ; Ottawa, Canada
              [754 ]ISNI 0000 0004 0633 727X, GRID grid.415354.2, , Kingston General Hospital, ; Kingston, Canada
              [755 ]GRID grid.415667.7, , Milton Keynes Hospital, ; Milton Keynes, UK
              [756 ]ISNI 0000 0001 2113 8111, GRID grid.7445.2, , Imperial College, ; London, UK
              [757 ]ISNI 0000 0004 0368 863X, GRID grid.439664.a, , Buckinghamshire Healthcare NHS Trust, ; Aylesbury, UK
              [758 ]GRID grid.435544.7, , IPO -Porto, ; Porto, Portugal
              [759 ]ISNI 0000 0000 9825 7840, GRID grid.411714.6, , Glasgow Royal Infirmary, ; Glasgow, UK
              [760 ]ISNI 0000 0001 0668 7884, GRID grid.5596.f, , KU Leuven, ; Leuven, Belgium
              [761 ]ISNI 0000 0000 9825 7840, GRID grid.411714.6, , Glasgow Royal Infirmary, ; Glasgow, UK
              [762 ]ISNI 0000 0000 9825 7840, GRID grid.411714.6, , Glasgow Royal Infirmary, ; Glasgow, UK
              [763 ]Ernesto Dornelles Hospital, Porto Alegre, Brazil
              [764 ]ISNI 0000 0000 9825 7840, GRID grid.411714.6, , Glasgow Royal Infirmary, ; Glasgow, UK
              [765 ]ISNI 0000 0004 0370 4214, GRID grid.415355.3, , Gelre Ziekenhuizen, ; Apeldoorn, Netherlands
              [766 ]ISNI 0000 0001 2179 1970, GRID grid.21006.35, , University of Canterbury, ; Christchurch, New Zealand
              [767 ]ISNI 0000 0004 0614 1349, GRID grid.414299.3, , Christchurch Hospital, ; Christchurch, New Zealand
              [768 ]Surrey and Sussex NHS Trust, Redhill, UK
              [769 ]ISNI 0000 0000 9984 5644, GRID grid.413314.0, , The Canberra Hospital, ; Hughes, ACT Australia
              [770 ]ISNI 0000 0001 2180 7477, GRID grid.1001.0, , ANU Medical School, ; Canberra, Australia
              [771 ]ISNI 0000 0001 1092 2592, GRID grid.8302.9, , Ege University School of Medicine, ; Izmir, Turkey
              [772 ]ISNI 0000 0004 0454 9420, GRID grid.411795.f, , katip Celebi University, ; Izmir, Turkey
              [773 ]ISNI 0000 0001 2260 6941, GRID grid.7155.6, , Alexandria University Faculty of medicine, ; Alexandria, Egypt
              [774 ]ISNI 0000 0004 1804 7827, GRID grid.417966.b, , Fortis Escorts Heart Institute, ; New Delhi, India
              [775 ]ISNI 0000 0004 4653 2037, GRID grid.464839.4, , FMRI, ; Gurgaon, India
              [776 ]GRID grid.417285.d, , Philips Research North America, ; Cambridge, USA
              [777 ]ISNI 0000 0004 0489 4320, GRID grid.429705.d, , King’s College Hospital NHS Foundation Trust, ; London, UK
              [778 ]GRID grid.413466.2, , Hospital Sao Rafael, ; Salvador, Brazil
              [779 ]ISNI 0000 0001 2297 2036, GRID grid.411074.7, , Hospital das Clinicas, ; Sao Paulo, Brazil
              [780 ]ISNI 0000 0004 0378 8294, GRID grid.62560.37, , Brigham and Women’s Hospital, ; Boston, USA
              [781 ]St Helens and Knowsley, Liverpool, UK
              [782 ]STH, Sheffield, UK
              [783 ]GRID grid.419135.b, , Sheffield Teaching Hospitals, ; Sheffield, UK
              [784 ]ISNI 0000 0004 0417 1894, GRID grid.417083.9, , Whiston Hospital, ; Prescot, UK
              [785 ]ISNI 0000 0004 0641 3308, GRID grid.415050.5, , Freeman Hospital, ; Newcastle upon Tyne, UK
              [786 ]GRID grid.413466.2, , Hospital Sao Rafael, ; Salvador, Brazil
              [787 ]ISNI 0000 0001 2297 2036, GRID grid.411074.7, , Hospital das Clinicas, ; Sao Paulo, Brazil
              [788 ]Hospital Nove de Julho, Sao Paulo, Brazil
              [789 ]GRID grid.15628.38, , University Hospital Coventry and Warwickshire, ; Coventry, UK
              [790 ]ISNI 0000 0000 9743 1587, GRID grid.413104.3, , Sunnybrook Health Sciences Centre, ; Toronto, Canada
              [791 ]ISNI 0000 0000 9506 6213, GRID grid.422655.2, , NHS Scotland, ; Glasgow, UK
              [792 ]ISNI 0000 0004 0488 7120, GRID grid.4912.e, , Royal College of Surgeons of Ireland, ; Dublin, Ireland
              [793 ]ISNI 0000 0001 2312 1970, GRID grid.5132.5, , University Leiden, ; Leiden, Netherlands
              [794 ]ISNI 0000 0004 0370 4214, GRID grid.415355.3, , Gelre Hospitals, ; Apeldoorn, Netherlands
              [795 ]ISNI 0000 0004 1754 9227, GRID grid.12380.38, , VU University Amsterdam, ; Amsterdam, Netherlands
              [796 ]Hospital de Santo António, Oporto Hospital Center, Porto, Portugal
              [797 ]ISNI 000000040459992X, GRID grid.5645.2, , Erasmus MC, ; Rotterdam, Netherlands
              [798 ]Faculty of Psychology and Educational Sciences, Heerlen, Netherlands
              [799 ]ISNI 0000 0001 2157 2938, GRID grid.17063.33, , University of Toronto at Scarborough, ; Scarborough, ON Canada
              [800 ]ISNI 0000 0004 0571 546X, GRID grid.413548.f, , Hamad medical corporation, ; Doha, Qatar
              [801 ]ISNI 0000 0001 1016 9625, GRID grid.9008.1, , University of Szeged, ; Szeged, Hungary
              [802 ]Jahn Ferenc Hospital, Budapest, Hungary
              [803 ]ISNI 0000 0001 0663 9479, GRID grid.9679.1, , University of Pécs, ; Pécs, Hungary
              [804 ]ISNI 0000 0004 0578 1096, GRID grid.414977.8, , Jessa Ziekenhuis, ; Hasselt, Belgium
              [805 ]GRID grid.412248.9, , Hospital Clinico Universidad de Chile, ; Santiago, Chile
              [806 ]ISNI 0000 0004 0417 0461, GRID grid.424926.f, , Royal Marsden Hospital, ; London, UK
              [807 ]GRID grid.419135.b, , Sheffield Teaching Hospitals, ; Sheffield, UK
              [808 ]GRID grid.240988.f, , Tan Tock Seng hospital, ; Singapore, Singapore
              [809 ]ISNI 0000 0004 0642 1236, GRID grid.470048.f, , Centre Hospitalier de Lens, ; Lens, France
              [810 ]GRID grid.413466.2, , Hospital Sao Rafael, ; Salvador, Brazil
              [811 ]ISNI 0000 0001 2297 2036, GRID grid.411074.7, , Hospital das Clinicas, ; Sao Paulo, Brazil
              [812 ]Ntra Sra de Candelaria University Hospital, Santa Cruz de Tenerife, Spain
              [813 ]ISNI 0000 0004 1936 9924, GRID grid.89336.37, , University of Texas at Austin, ; San Antonio, USA
              [814 ]ISNI 0000 0004 0617 6058, GRID grid.414315.6, , Beaumont Hospital, ; Dublin, Ireland
              [815 ]GRID grid.430747.3, , St Helens and Knowsley teaching hospitals, ; Liverpool, UK
              [816 ]Nuovo Ospedale Civile Sant’Agostino Estense, Modena, Italy
              [817 ]ISNI 0000 0004 0621 2899, GRID grid.414122.0, , PICU, Hippokration General Hospital, ; Thessaloniki, Greece
              [818 ]ISNI 0000 0001 0481 6099, GRID grid.5012.6, , Maastricht University, ; Maastricht, Netherlands
              [819 ]GRID grid.412966.e, , Maastricht University Medical Center, ; Maastricht, Netherlands
              [820 ]ISNI 0000 0004 0626 3418, GRID grid.411414.5, , University Hospital Antwerp, ; Edegem, Belgium
              [821 ]ISNI 0000000404654431, GRID grid.5650.6, , Academic Medical Center, ; Amsterdam, Netherlands
              [822 ]St Helens and Knoowsley, Prescot, UK
              [823 ]ISNI 0000 0004 1936 7697, GRID grid.22072.35, , University of Calgary, ; Calgary, Canada
              [824 ]ISNI 0000 0001 2290 8069, GRID grid.8767.e, , Vrije Universiteit Brussel, ; Brussel, Belgium
              [825 ]ISNI 0000000090126352, GRID grid.7692.a, , EMGO+/VU University medical center, ; Utrecht, Netherlands
              [826 ]ISNI 0000 0004 0626 3362, GRID grid.411326.3, , Universitair Ziekenhuis Brussel, ; Brussel, Belgium
              [827 ]GRID grid.439787.6, , University Hospital Lewisham, ; London, UK
              [828 ]GRID grid.439484.6, , Queen Elizabeth Hospital, ; London, UK
              [829 ]GRID grid.429537.e, , Lewisham & Greenwich NHS Trust, ; London, UK
              [830 ]ISNI 0000 0001 2193 314X, GRID grid.8756.c, , University of Glasgow, ; Glasgow, UK
              [831 ]ISNI 0000 0001 0523 9342, GRID grid.413301.4, , NHS Greater Glasgow and Clyde, ; Glasgow, UK
              [832 ]National Burn Unit, Montevideo, Uruguay
              [833 ]GRID grid.414794.b, , Hospital Maciel, ; Montevideo, Uruguay
              [834 ]GRID grid.416373.4, , St Elisabeth Ziekenhuis, ; Tilburg, Netherlands
              [835 ]ISNI 0000 0004 1757 8749, GRID grid.414818.0, , Fondazione IRCCS Ca’ Granda - Ospedale maggiore Policlinico, ; Milan, Italy
              [836 ]ISNI 0000 0004 1758 0566, GRID grid.417623.5, , Istituto per lo Studio e la Prevenzione Oncologica, ; Florence, Italy
              Article
              1208
              10.1186/s13054-016-1208-6
              5493079
              27885969
              3bbf13b9-ebf4-4e50-8dc7-5e7b118eb499
              © The Author(s). 2016

              Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

              36th International Symposium on Intensive Care and Emergency Medicine
              Brussels, Belgium
              15-18 March 2016
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              Emergency medicine & Trauma
              Emergency medicine & Trauma

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