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      Venous leg ulceration pathophysiology and evidence based treatment.

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          Abstract

          Venous leg ulceration (VLU) is one of the most predominate medical disorders worldwide and in the western hemisphere it affects around 1.5% of the general population and up to 5% of the elderly population. Unfortunately, this trend will only increase given the growth of an aging population worldwide. Understanding its pathophysiology that begins with venous hemodynamic abnormalities and leads to inflammatory alterations with microcirculatory changes is critical to delivering effective curative therapy. As such, the main component to treatment is reversing the underlying venous hypertension and pro-inflammatory milieu using compression treatment along with various adjuvant therapies. Given its impact, a comprehensive multi-pronged approach to care, treatment and prevention is required to reverse the increasing trend that is observed worldwide.

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          Author and article information

          Journal
          Vasc Med
          Vascular medicine (London, England)
          SAGE Publications
          1477-0377
          1358-863X
          Apr 2015
          : 20
          : 2
          Affiliations
          [1 ] Department of Internal Medicine, Section of Cardiovascular Medicine, University of California, Davis Medical Center, Sacramento, CA, USA ywchi@yahoo.com.
          [2 ] Vascular Surgery Division, VA Boston Healthcare System, West Roxbury, MA, USA Division of Vascular and Endovascular Surgery, Brigham and Women's Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA.
          Article
          20/2/168
          10.1177/1358863X14568677
          25832604
          3bbf70d8-f223-4b28-a49a-f7782ec7f4a9
          History

          chronic venous disorder,compression therapy,endovenous therapy,inflammation,venous disease classification,venous leg ulceration

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