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      • Record: found
      • Abstract: found
      • Article: found

      Choroidal Schwannoma: Immunohistochemical and Electron-Microscopic Study

      case-report
      a , b
      Ophthalmologica
      S. Karger AG
      Electron microscopy, Choroidal schwannoma, Immunohistochemistry

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          Abstract

          Schwannoma (neurilemoma) arising from the ciliary body and choroid is a rare form of intraocular tumor and usually misdiagnosed clinically as amelanotic melanoma. This case report describes a 73-year-old woman who developed a large nonpigmented intraocular tumor of the choroid in the left eye and underwent enucleation with a clinical diagnosis of malignant melanoma. The tumor consisted of spindle-shaped cells with an indefinite cytoplasm and twisted nuclei, which had positive immunoreactivity for S-100 protein, vimentin, glial fibrillary acidic protein and neural cell adhesion molecule. A continuous basal lamina encompassing the tumor cells was demonstrated by immunostaining for laminin and type IV collagen. Ultrastructurally, tumor cells with scant organelles had delicate cytoplasmic processes apposing each other, all indicative of Schwann cell origin. In reexamination of fluorescein angiograms, ultrasonograms and magnetic resonance images, no findings were incompatible with a diagnosis of choroidal melanoma. Histopathological studies showed that the tumor was a schwannoma. At present, we do not have a benchmark for the clinical diagnosis of intraocular schwannoma.

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            Author and article information

            Journal
            OPH
            Ophthalmologica
            10.1159/issn.0030-3755
            Ophthalmologica
            S. Karger AG
            0030-3755
            1423-0267
            2000
            April 2000
            15 March 2000
            : 214
            : 2
            : 156-160
            Affiliations
            Departments of aOphthalmology and bPathology, Okayama University Medical School, Okayama City, Japan
            Article
            27488 Ophthalmologica 2000;214:156–160
            10.1159/000027488
            10720924
            3bc5e385-c1c5-4db8-a25f-ae467fa70ec3
            © 2000 S. Karger AG, Basel

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            History
            Page count
            Figures: 5, References: 12, Pages: 5
            Categories
            Case Report · Description de cas · Fallbericht

            Vision sciences,Ophthalmology & Optometry,Pathology
            Choroidal schwannoma,Immunohistochemistry,Electron microscopy

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