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Claudin 1 is one of the tight junction proteins, which are critical in the maintenance
of epithelial integrity. Aberrant regulation of CLDN1 and its correlation with β-catenin
have been discovered in malignant tumors. The present study aimed to investigate the
expression profile and clinical relevance of CLDN1 and β-catenin. The protein levels
of CLDN1 and β-catenin were examined using immunohistochemical staining. The characteristics
of expression profile and prognostic value were analyzed using Pearson's χ² test and
Kaplan-Meier analysis, respectively. β-catenin overexpression and knockdown were used
to investigate its role in regulating CLDN1 expression. We showed that CLDN1 was overexpressed
in intestinal-type, presence of lymph node metastasis, higher TNM stage in gastric
cancer patients and correlated with decreased overall survival. The characteristics
of CLDN1 expression were associated with that of β-catenin. CLDN1 and β-catenin showed
similar prognostic value in intestinal-type gastric cancers. β-catenin knockdown and
overexpression in cell models revealed a positive relation between CLDN1 and β-catenin.
Our study demonstrated that CLDN1 is a biomarker for intestinal-type gastric cancer
with shorter survival. The expression of CLDN1 was strongly associated with β-catenin
in gastric cancer patients and a gastric cancer cell model.