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      Age at Growth Hormone Therapy Start and First-Year Responsiveness to Growth Hormone Are Major Determinants of Height Outcome in Idiopathic Short Stature

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          Aim: To develop methods to identify factors associated with a favorable outcome in GH-treated children with idiopathic short stature (ISS). Methods: From 4,685 children listed as having ISS within KIGS (Pfizer International Growth Database), we studied (a) the prediction model group (n = 657) to develop the first-year prediction model, and (b) the near adult height group (NAH; n = 256) which received GH for >4 years to develop descriptive models for adult height and overall height gain. Results: NAH group at GH start: age was 10.0 years, height –2.5 SD score (SDS), weight –2.3 SDS, height minus mid-parental height (MPH) –1.5 SDS; GH dose 0.19 mg/kg/week. Height gain was 1.1 SDS at a median age of 17.2 years. Growth response correlated positively with GH dose and weight at the start of GH treatment, and negatively with age and height SDS minus MPH SDS. The model explains 39% (error SD 1.2 cm) of the variability. Adult height correlated (R<sup>2</sup> = 0.64) positively with height at GH start, MPH and the first-year responsiveness to GH, and negatively with age. Conclusions: Prepubertal children with ISS who show an appropriate first-year response to GH are likely to benefit from long-term treatment, even on low GH dosages.

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          Most cited references 29

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          Centers for Disease Control and Prevention 2000 Growth Charts for the United States: Improvements to the 1977 National Center for Health Statistics Version

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            Tables for predicting adult height from skeletal age: revised for use with the Greulich-Pyle hand standards.

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                Author and article information

                Horm Res Paediatr
                Hormone Research in Paediatrics
                S. Karger AG
                July 2007
                16 January 2007
                : 68
                : 2
                : 53-62
                aPaediatric Endocrinology Section, Children’s Hospital, University of Tübingen, Tübingen, Germany; bPfizer Inc., Stockholm, Sweden; cDepartment of Paediatrics, St Mary’s Hospital, Manchester, UK; dDepartment of Paediatrics, Istanbul Faculty of Medicine, Istanbul, Turkey; ePediatric Growth Research Center, Department of Pediatrics, Queen Silvia Children’s Hospital, Sahlgrenska Academy of Gothenburg University, Gothenburg, Sweden; fPfizer Inc., New York, N.Y., and gBaystate Children’s Hospital, Tufts University School of Medicine, Springfield, Mass., USA
                98707 Horm Res 2007;68:53–62
                © 2007 S. Karger AG, Basel

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                Page count
                Figures: 1, Tables: 4, References: 53, Pages: 10
                Original Paper


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