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      Bioceramics and bone healing

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          Abstract

          • Calcium phosphates have long been used as synthetic bone grafts. Recent studies have shown that the modulation of composition and textural properties, such as nano-, micro- and macro-porosity, is a powerful strategy to control and synchronize material resorption and bone formation.

          • Biomimetic calcium phosphates, which closely mimic the composition and structure of bone mineral, can be produced using low-temperature processing routes, and offer the possibility to modulate the material properties to a larger extent than conventional high temperature sintering processes.

          • Advanced technologies open up new possibilities in the design of bioceramics for bone regeneration; 3D-printing technologies, in combination with the development of hybrid materials with enhanced mechanical properties, supported by finite element modelling tools, are expected to enable the design and fabrication of mechanically competent patient-specific bone grafts.

          • The association of ions, drugs and cells allows leveraging of the osteogenic potential of bioceramic scaffolds in compromised clinical situations, where the intrinsic bone regeneration potential is impaired.

          Cite this article: EFORT Open Rev 2018;3 DOI: 10.1302/2058-5241.3.170056

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          Most cited references72

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          Bone substitutes: an update.

          Autograft is considered ideal for grafting procedures, providing osteoinductive growth factors, osteogenic cells, and an osteoconductive scaffold. Limitations, however, exist regarding donor site morbidity and graft availability. Allograft on the other hand, posses the risk of disease transmission. Synthetic graft substitutes lack osteoinductive or osteogenic properties. Composite grafts combine scaffolding properties with biological elements to stimulate cell proliferation and differentiation and eventually osteogenesis. We present here an overview of bone grafts and graft substitutes available for clinical applications.
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            Calcium phosphate-based osteoinductive materials.

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              Osteoimmunomodulation for the development of advanced bone biomaterials

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                Author and article information

                Journal
                EFORT Open Rev
                EFORT Open Rev
                EFORT Open Reviews
                British Editorial Society of Bone and Joint Surgery
                2058-5241
                May 2018
                21 May 2018
                : 3
                : 5
                : 173-183
                Affiliations
                [1 ]Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya (UPC), Spain
                [2 ]Mimetis Biomaterials, Spain
                Author notes
                [*]M. P. Ginebra, Biomaterials, Biomechanics and Tissue Engineering Department, Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya, Av. Eduard Maristany 10-14, 08019, Barcelona, Spain. Email: maria.pau.ginebra@ 123456upc.edu
                Article
                10.1302_2058-5241.3.170056
                10.1302/2058-5241.3.170056
                5994622
                29951254
                3c014fea-3149-4f73-8068-080192eca730
                © 2018 The author(s)

                This article is distributed under the terms of the Creative Commons Attribution-Non Commercial 4.0 International (CC BY-NC 4.0) licence ( https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed.

                History
                Categories
                Instructional Lecture: General Orthopaedics
                10
                Bioceramics
                Bone Healing
                Bone Graft
                Calcium Phosphate

                bioceramics,bone healing,bone graft,calcium phosphate
                bioceramics, bone healing, bone graft, calcium phosphate

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