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      Cellular functions regulated by Src family kinases.

      Annual review of cell and developmental biology

      physiology, genetics, src-Family Kinases, Humans, Cell Physiological Phenomena, Animals

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          Abstract

          Src family protein tyrosine kinases are activated following engagement of many different classes of cellular receptors and participate in signaling pathways that control a diverse spectrum of receptor-induced biological activities. While several of these kinases have evolved to play distinct roles in specific receptor pathways, there is considerable redundancy in the functions of these kinases, both with respect to the receptor pathways that activate these kinases and the downstream effectors that mediate their biological activities. This chapter reviews the evidence implicating Src family kinases in specific receptor pathways and describes the mechanisms leading to their activation, the targets that interact with these kinases, and the biological events that they regulate.

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          Author and article information

          Journal
          9442882
          10.1146/annurev.cellbio.13.1.513

          Chemistry

          physiology, genetics, src-Family Kinases, Humans, Cell Physiological Phenomena, Animals

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