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      Complement Components and Fibrinogen: Correlations and Association with Previous Myocardial Infarction

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          Abstract

          Serum complement levels have been found to be predictive of myocardial infarction up to 4 years before the acute event. To assess whether they are a marker of a hypercoagulable state, the serum or plasma levels of C3, C4, C3a, C4a, Cl inactivator, antithrombin III, protein S, protein C, fibrinogen and tissue plasminogen activator were measured in 31 patients with previous myocardial infarction and 33 controls (all males, 40-60 years old). C3, C4 and fibrinogen (which share the common characteristic of being acute phase proteins) were correlated and were associated with previous myocardial infarction, although this association persisted only for C4 in multivariate analysis. None of the coagulative variables directly involved in the complement system differed significantly in the two groups.

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          Author and article information

          Journal
          Journal ID (publisher-id): CRD
          Journal ID (nlm-ta): Cardiology
          Journal ID (doi): 10.1159/issn.0008-6312
          Title: Cardiology
          Publisher: S. Karger AG
          ISSN (Print): 0008-6312
          ISSN (Electronic): 1421-9751
          Publication date Subscription-year: 1995
          Publication date (Print): 1995
          Publication date (Electronic): 19 November 2008
          Volume: 86
          Issue: 3
          Pages: 232-237
          Affiliations
          aIstituto di Patologia Speciale Medica e Metodologia Clinica, Università di Bologna, bServizio di Angiologia e Malattie della Coagulazione, dLaboratorio Centralizzato e eServizio di Immunoematologia e Trasfusionale, S. Orsola Hospital, e cLaboratorio Centralizzato, M. Malpighi Hospital, Bologna, Italia
          Article
          Publisher ID: 176879 Other ID: Cardiology 1995;86:232–237
          DOI: 10.1159/000176879
          PubMed ID: 7614496
          SO-VID: 3c293ff7-cc51-4ac5-bbcf-8ba6f85221be
          Copyright © © 1995 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 19 August 1994
          Date accepted : 30 November 1994
          Page count
          Pages: 6
          Categories
          Subject: Coronary Care

          ScienceOpen disciplines: General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Keywords: Cl inactivator,Fibrinogen,Protein C,Protein S,Antithrombin III,Tissue plasminogen activator,Myocardial infarction,Complement 3,Complement 4,Complement activation
          Data availability:
          ScienceOpen disciplines: General medicine, Neurology, Cardiovascular Medicine, Internal medicine, Nephrology
          Keywords: Cl inactivator, Fibrinogen, Protein C, Protein S, Antithrombin III, Tissue plasminogen activator, Myocardial infarction, Complement 3, Complement 4, Complement activation

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