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      Complement Components and Fibrinogen: Correlations and Association with Previous Myocardial Infarction

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          Abstract

          Serum complement levels have been found to be predictive of myocardial infarction up to 4 years before the acute event. To assess whether they are a marker of a hypercoagulable state, the serum or plasma levels of C3, C4, C3a, C4a, Cl inactivator, antithrombin III, protein S, protein C, fibrinogen and tissue plasminogen activator were measured in 31 patients with previous myocardial infarction and 33 controls (all males, 40-60 years old). C3, C4 and fibrinogen (which share the common characteristic of being acute phase proteins) were correlated and were associated with previous myocardial infarction, although this association persisted only for C4 in multivariate analysis. None of the coagulative variables directly involved in the complement system differed significantly in the two groups.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1995
          1995
          19 November 2008
          : 86
          : 3
          : 232-237
          Affiliations
          aIstituto di Patologia Speciale Medica e Metodologia Clinica, Università di Bologna, bServizio di Angiologia e Malattie della Coagulazione, dLaboratorio Centralizzato e eServizio di Immunoematologia e Trasfusionale, S. Orsola Hospital, e cLaboratorio Centralizzato, M. Malpighi Hospital, Bologna, Italia
          Article
          176879 Cardiology 1995;86:232–237
          10.1159/000176879
          7614496
          © 1995 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Coronary Care

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