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Molecular targeting of glioblastoma: Drug discovery and therapies
Author(s):
Ren-Yuan Bai
,
Verena Staedtke
,
Gregory J. Riggins
Publication date
Created:
June 2011
Publication date
(Print):
June 2011
Journal:
Trends in Molecular Medicine
Publisher:
Elsevier BV
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There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Despite advances in treatment for glioblastoma multiforme (GBM), patient prognosis remains poor. Although there is growing evidence that molecular targeting could translate into better survival for GBM, current clinical data show limited impact on survival. Recent progress in GBM genomics implicate several activated pathways and numerous mutated genes. This molecular diversity can partially explain therapeutic resistance and several approaches have been postulated to target molecular changes. Furthermore, most drugs are unable to reach effective concentrations within the tumor owing to elevated intratumoral pressure, restrictive vasculature and other limiting factors. Here, we describe the preclinical and clinical developments in treatment strategies of GBM. We review the current clinical trials for GBM and discuss the challenges and future directions of targeted therapies. Copyright © 2011 Elsevier Ltd. All rights reserved.
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Hematology and Oncology Discovery
Author and article information
Journal
Title:
Trends in Molecular Medicine
Abbreviated Title:
Trends in Molecular Medicine
Publisher:
Elsevier BV
ISSN (Print):
14714914
Publication date Created:
June 2011
Publication date (Print):
June 2011
Volume
: 17
Issue
: 6
Pages
: 301-312
Article
DOI:
10.1016/j.molmed.2011.01.011
PMC ID:
4101015
PubMed ID:
21411370
SO-VID:
3c32df65-cfae-4a89-8708-a7693150c71a
Copyright ©
© 2011
License:
https://www.elsevier.com/tdm/userlicense/1.0/
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