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Microencapsulation of dopamine neurons derived from human induced pluripotent stem cells
January 2015
January 2015
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Abstract
Dopamine neurons derived from induced pluripotent stem cells have been widely studied
for the treatment of Parkinson's disease. However, various difficulties remain to
be overcome, such as tumor formation, fragility of dopamine neurons, difficulty in
handling large numbers of dopamine neurons, and immune reactions. In this study, human
induced pluripotent stem cell-derived precursors of dopamine neurons were encapsulated
in agarose microbeads. Dopamine neurons in microbeads could be handled without specific
protocols, because the microbeads protected the fragile dopamine neurons from mechanical
stress.