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      Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice

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      The Journal of Experimental Medicine
      The Rockefeller University Press

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          Abstract

          Interleukin 7 (IL-7) stimulates the proliferation of B cell progenitors, thymocytes, and mature T cells through an interaction with a high affinity receptor (IL-7R) belonging to the hematopoietin receptor superfamily. We have further addressed the role of IL-7 and its receptor during B and T cell development by generating mice genetically deficient in IL-7R. Mutant mice display a profound reduction in thymic and peripheral lymphoid cellularity. Analyses of lymphoid progenitor populations in IL-7R-deficient mice define precisely those developmental stages affected by the mutation and reveal a critical role for IL-7R during early lymphoid development. Significantly, these studies indicate that the phase of thymocyte expansion occurring before the onset of T cell receptor gene rearrangement is critically dependent upon, and mediated by the high affinity receptor for IL-7.

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          Author and article information

          Journal
          J Exp Med
          The Journal of Experimental Medicine
          The Rockefeller University Press
          0022-1007
          1540-9538
          1 November 1994
          : 180
          : 5
          : 1955-1960
          Article
          95053726
          2191751
          7964471
          3c36202d-a1dc-447f-8f03-d3ec00b57530
          Categories
          Articles

          Medicine
          Medicine

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