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      RNA regulons: coordination of post-transcriptional events.

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      Nature reviews. Genetics
      Springer Science and Business Media LLC

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          Abstract

          Recent findings demonstrate that multiple mRNAs are co-regulated by one or more sequence-specific RNA-binding proteins that orchestrate their splicing, export, stability, localization and translation. These and other observations have given rise to a model in which mRNAs that encode functionally related proteins are coordinately regulated during cell growth and differentiation as post-transcriptional RNA operons or regulons, through a ribonucleoprotein-driven mechanism. Here I describe several recently discovered examples of RNA operons in budding yeast, fruitfly and mammalian cells, and their potential importance in processes such as immune response, oxidative metabolism, stress response, circadian rhythms and disease. I close by considering the evolutionary wiring and rewiring of these combinatorial post-transcriptional gene-expression networks.

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          Author and article information

          Journal
          Nat Rev Genet
          Nature reviews. Genetics
          Springer Science and Business Media LLC
          1471-0056
          1471-0056
          Jul 2007
          : 8
          : 7
          Affiliations
          [1 ] Department of Molecular Genetics & Microbiology, Duke University Medical Center, Box 3020, Durham, North Carolina 27710, USA. keene001@mc.duke.edu
          Article
          nrg2111
          10.1038/nrg2111
          17572691
          3c3a8c72-4dd3-4c6d-a7b9-1f857d823269
          History

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