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      Comparative Genomics Identifies Candidate Genes for Infectious Salmon Anemia (ISA) Resistance in Atlantic Salmon (Salmo salar)

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          Infectious salmon anemia (ISA) has been described as the hoof and mouth disease of salmon farming. ISA is caused by a lethal and highly communicable virus, which can have a major impact on salmon aquaculture, as demonstrated by an outbreak in Chile in 2007. A quantitative trait locus (QTL) for ISA resistance has been mapped to three microsatellite markers on linkage group (LG) 8 (Chr 15) on the Atlantic salmon genetic map. We identified bacterial artificial chromosome (BAC) clones and three fingerprint contigs from the Atlantic salmon physical map that contains these markers. We made use of the extensive BAC end sequence database to extend these contigs by chromosome walking and identified additional two markers in this region. The BAC end sequences were used to search for conserved synteny between this segment of LG8 and the fish genomes that have been sequenced. An examination of the genes in the syntenic segments of the tetraodon and medaka genomes identified candidates for association with ISA resistance in Atlantic salmon based on differential expression profiles from ISA challenges or on the putative biological functions of the proteins they encode. One gene in particular, HIV-EP2/MBP-2, caught our attention as it may influence the expression of several genes that have been implicated in the response to infection by infectious salmon anemia virus (ISAV). Therefore, we suggest that HIV-EP2/MBP-2 is a very strong candidate for the gene associated with the ISAV resistance QTL in Atlantic salmon and is worthy of further study.

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          The online version of this article (doi:10.1007/s10126-010-9284-0) contains supplementary material, which is available to authorized users.

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              The nuclear factor-kappaB (NF-kappaB)/REL family of transcription factors has a central role in coordinating the expression of a wide variety of genes that control immune responses. There has been intense scientific activity in the NF-kappaB field owing to the involvement of these factors in the activation and regulation of key molecules that are associated with diseases ranging from inflammation to cancer. In this review, we focus on our current understanding of NF-kappaB regulation and its role in the immune system and inflammatory diseases. We also discuss the role of NF-kappaB proteins as potential therapeutic targets in clinical applications.

                Author and article information

                +1-778-7825637 , +1-778-7825583 ,
                Mar Biotechnol (NY)
                Marine Biotechnology (New York, N.y.)
                Springer-Verlag (New York )
                16 April 2010
                16 April 2010
                April 2011
                : 13
                : 2
                : 232-241
                [1 ]Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC Canada V5A 1S6
                [2 ]Department of Biology, University of Victoria, Victoria, BC Canada V8W 3N5
                © The Author(s) 2010
                Original Article
                Custom metadata
                © Springer Science+Business Media, LLC 2011


                comparative genomics, disease resistance, atlantic salmon, infectious salmon anemia


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