31
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      DNA-cleavage induced by new macrocyclic Schiff base dinuclear Cu(I) complexes containing pyridyl pendant arms.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          A new series of dinuclear Cu(I) complexes with hexaazamacrocyclic Schiff base ligand containing pyridyl pendant arms has been synthesized and characterized. The solid-state structures of [Cu(2)(I)(bsp3py)](CF(3)SO(3))(2) (1(CF(3)SO(3))(2)), [Cu(2)(I)(bsm3py)](SbF(6))(2) (2(SbF(6))(2)), and [Cu(2)(I)(bsp2py)](CF(3)SO(3))(2) (3(CF(3)SO(3))(2)) have been established by single-crystal X-ray diffraction analysis. The geometries of the copper centers in all three cases are almost identical showing a distorted tetrahedral coordination, very close to a trigonal pyramidal arrangement. Interactions of complexes with calf thymus DNA have been investigated by circular dichroism spectroscopy (CD) which suggests that the interaction for each complex is a nonintercalative mode with regard to DNA. The electrophoretic mobility study and the atomic force microscopy (AFM) in the presence of H(2)O(2) reveal a cleavage of pBR322 supercoiled DNA that depends on the nature of the Cu(I) complex used. The most efficient reactivity is observed for complexes 1(CF(3)SO(3))(2) and 2(CF(3)SO(3))(2) whereas complex 3(CF(3)SO(3))(2) displays a lesser reactivity. The different DNA-cleavage activity of complexes 1-3 is due the different electronic factors and complex topology induced by the natures of the different ligands. This work constitutes an example of how small modifications introduced in the macrocyclic backbone of the metal complexes lead to dramatic changes in the nuclease activity.

          Related collections

          Author and article information

          Journal
          Inorg Chem
          Inorganic chemistry
          1520-510X
          0020-1669
          Dec 07 2009
          : 48
          : 23
          Affiliations
          [1 ] Departament de Química, Universitat de Girona, Campus de Montilivi, E-17071 Girona, Spain.
          Article
          10.1021/ic901488j
          19883105
          3c3e7817-0717-4bc4-8810-2a146eb75593
          History

          Comments

          Comment on this article