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      Diosgenin increased DDX3 expression in hepatocellular carcinoma

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          Abstract

          Liver cancer, one of the most common malignant tumors occurred worldwide, has emerged as a main health trouble and accounts for leading cancer-related death. Diosgenin is provided as an important material in the pharmaceutical industry, and is used to manage various medical troubles such as cancer because of its multiple bioactivities. DEAD box polypeptide 3 (DDX3) is involved in cancer biogenesis and modulates cancer progression. However, the role of DDX3 in human hepatocellular carcinoma (HCC) has not been fully understood. In the present study, we investigated the anti-tumor effects of diosgenin on HCC cells and whether DDX3 is involved in its antitumor activity. We observed that diosgenin dramatically inhibited cell proliferation, triggered apoptotic cell death, induced G2/M phase arrest, suppressed cell migration and invasion abilities. Moreover, the expression of DDX3 was measured and the results showed that DDX3 was significantly up-regulated upon diosgenin exposure. All together, our data indicated that diosgenin shows a cytotoxic effect on HCC cells and has potential therapeutic values for HCC patients.

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          Author and article information

          Journal
          Am J Transl Res
          Am J Transl Res
          ajtr
          American Journal of Translational Research
          e-Century Publishing Corporation
          1943-8141
          2018
          15 November 2018
          : 10
          : 11
          : 3590-3599
          Affiliations
          [1 ] Department of Liver Disease, Yantai Infectious Diseases Hospital Yantai, Shandong, China
          [2 ] Department of Medical Oncology, Yantai Yuhuangding Hospital Affiliated with Qingdao University Yantai, Shandong, China
          Author notes
          Address correspondence to: Dr. Yu Cheng, Department of Medical Oncology, Yantai Yuhuangding Hospital, No. 20 Yuhuangding East Road, Yantai, Shandong, China. E-mail: yuchengyantai@ 123456126.com
          [*]

          Equal contributors.

          Article
          PMC6291714 PMC6291714 6291714
          6291714
          30662610
          3c47eecb-2461-4304-9bed-73249eeed42f
          AJTR Copyright © 2018
          History
          : 21 March 2018
          : 21 October 2018
          Categories
          Original Article

          invasion,proliferation,diosgenin,hepatocellular carcinoma,DDX3

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