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      Childhood Febrile Seizures: Overview and Implications

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          Abstract

          This article provides an overview of the latest knowledge and understanding of childhood febrile seizures. This review also discusses childhood febrile seizure occurrence, health services utilization and treatment costs. Parental reactions associated with its occurrence and how healthcare providers can assist parents with dealing effectively with this potentially frightening and anxiety-producing event are also discussed.

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          Children with Respiratory Disease Associated with Metapneumovirus in Hong Kong

          J.S. Malik Peiris, Wing-Hong Tang, Kwok Chan … (2003)
          Human metapneumovirus (HMPV) is a newly discovered pathogen thought to be associated with respiratory disease. We report the results of a study of 587 children hospitalized with respiratory infection over a 13-month period. HMPV was detected in the nasopharyngeal aspirates from 32 (5.5%) children by reverse transcription-polymerase chain reaction. HMPV infection was associated with clinical diagnoses of pneumonia (36%), asthma exacerbation (23%), or acute bronchiolitis (10%). When compared to those with respiratory syncytial virus infection, children with HMPV infection were older, and wheezing was more likely to represent asthma exacerbation rather than acute bronchiolitis. HMPV viral activity peaked during the spring-summer period in Hong Kong. Phylogenetically, all HMPV virus strains from Hong Kong belonged to one of the two genetic lineages previously described. HMPV contributed to 441.6 hospital admissions per 100,000 population <6 years of age.
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            Guidelines for epidemiologic studies on epilepsy. Commission on Epidemiology and Prognosis, International League Against Epilepsy.

            (2015)
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              Human herpesvirus-6 infection in children. A prospective study of complications and reactivation.

              Elizabeth Long, Nathan Knott, S Dewhurst … (1994)
              Infection with human herpesvirus-6 (HHV-6) is nearly universal in infancy or early childhood. However, the course of this infection, its complications, and its potential for persistence or reactivation remain unclear. We studied infants and children under the age of three years who presented to our emergency department with acute illnesses. Infants and young children without acute illness were studied as controls. HHV-6 infection was identified by blood-mononuclear-cell culture, serologic testing, and the polymerase chain reaction (PCR). No primary HHV-6 infection was found among 582 infants and young children with acute nonfebrile illnesses or among 352 controls without acute illness. Of 1653 infants and young children with acute febrile illnesses, 160 (9.7 percent) had primary HHV-6 infection, as documented by viremia and seroconversion. They ranged in age from 2 weeks to 25 months; 23 percent were under the age of 6 months. HHV-6 infections accounted for 20 percent of 365 visits to the emergency department for febrile illnesses among children 6 to 12 months old. Of the 160 infants and young children with acute HHV-6 infections, 21 (13 percent) were hospitalized, and 21 had seizures. Often the seizures appeared late and were prolonged or recurrent. HHV-6 infections accounted for one third of all febrile seizures in children up to the age of two years. In follow-up studies over a period of one to two years, the HHV-6 genome persisted in blood mononuclear cells after primary infection in 37 of 56 children (66 percent). Reactivation, sometimes with febrile illnesses, was suggested by subsequent increases in antibody titers in 16 percent (30 of 187) and by PCR in 6 percent (17 of 278). No recurrent viremia was detected. Of 41 healthy newborns studied, 12 (29 percent) had the HHV-6 genome in their blood mononuclear cells; nevertheless, 6 of these newborns subsequently had primary HHV-6 infections. In infants and young children HHV-6 infection is a major cause of visits to the emergency department, febrile seizures, and hospitalizations. Perinatal transmission may occur, with possible asymptomatic, transient, or persistent neonatal infection.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Int J Med Sci
                Journal ID (publisher-id): ijms
                Title: International Journal of Medical Sciences
                Publisher: Ivyspring International Publisher (Sydney )
                ISSN (Electronic): 1449-1907
                Publication date Collection: 2007
                Publication date (Electronic): 7 April 2007
                Volume: 4
                Issue: 2
                Pages: 110-114
                Affiliations
                Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA 91101, USA
                Author notes
                Correspondence to: Tonia Jones, RN, FNP, Ph.D, Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA 91101, Phone: (626) 564-3483, Fax: (626) 564-3430, Email: tonia.l.jones@ 123456kp.org

                Conflict of interest: The authors have declared that no conflict of interest exists.

                Article
                Publisher ID: ijmsv04p0110
                DOI: 10.7150/ijms.4.110
                PMC ID: 1852399
                PubMed ID: 17479160
                SO-VID: 3c55db76-037e-41b8-806d-4a3d3315670e
                Copyright © © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
                History
                Date received : 14 March 2007
                Date accepted : 4 April 2007
                Categories
                Subject: Review

                ScienceOpen disciplines: Medicine
                Keywords: childhood febrile seizure,anxiety,health services utilization,parental reaction,parental education
                Data availability:
                ScienceOpen disciplines: Medicine
                Keywords: childhood febrile seizure, anxiety, health services utilization, parental reaction, parental education

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