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      Flavonoids: antioxidants or signalling molecules?

      1 , ,
      Free radical biology & medicine
      Elsevier BV

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          Abstract

          Many studies are accumulating that report the neuroprotective, cardioprotective, and chemopreventive actions of dietary flavonoids. While there has been a major focus on the antioxidant properties, there is an emerging view that flavonoids, and their in vivo metabolites, do not act as conventional hydrogen-donating antioxidants but may exert modulatory actions in cells through actions at protein kinase and lipid kinase signalling pathways. Flavonoids, and more recently their metabolites, have been reported to act at phosphoinositide 3-kinase (PI 3-kinase), Akt/protein kinase B (Akt/PKB), tyrosine kinases, protein kinase C (PKC), and mitogen activated protein kinase (MAP kinase) signalling cascades. Inhibitory or stimulatory actions at these pathways are likely to affect cellular function profoundly by altering the phosphorylation state of target molecules and by modulating gene expression. A clear understanding of the mechanisms of action of flavonoids, either as antioxidants or modulators of cell signalling, and the influence of their metabolism on these properties are key to the evaluation of these potent biomolecules as anticancer agents, cardioprotectants, and inhibitors of neurodegeneration

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          Author and article information

          Journal
          Free Radic Biol Med
          Free radical biology & medicine
          Elsevier BV
          0891-5849
          0891-5849
          Apr 01 2004
          : 36
          : 7
          Affiliations
          [1 ] Wolfson Centre for Age-Related Diseases, GKT School of Biomedical Sciences, King's College London, Guy's Campus, London SE1 9RT, UK. robert.williams@kcl.ac.uk
          Article
          S0891584904000334
          10.1016/j.freeradbiomed.2004.01.001
          15019969
          3c590b23-bf97-45f7-9b23-08b1d894ea9e
          History

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