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      In vivo microdialysis/liquid chromatography/tandem mass spectrometry for the on-line monitoring of melatonin in rat.

      Rapid Communications in Mass Spectrometry
      Animals, Biotransformation, Calibration, Chromatography, Liquid, Injections, Intraperitoneal, Male, Mass Spectrometry, Melatonin, analogs & derivatives, analysis, pharmacokinetics, Microdialysis, Rats, Rats, Sprague-Dawley

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          Abstract

          Liquid chromatography/tandem mass spectrometry (LC/MS/MS) has been coupled to in vivo microdialysis for on-line monitoring of melatonin in a freely moving rat for a period of 15 hours. A microdialysis probe was surgically implanted into the jugular vein of the rat, and deionized water was used as the perfusion medium at a flow rate of 1.0 microL/min. Microdialysis samples were collected in an on-line injector with sample injection every 30 minutes. Melatonin was dosed by intraperitoneal (i.p.) injection and then monitored by microdialysis/LC/MS/MS. The whole experiment, including the microdialysis sampling and sample injection into the LC/MS system, was fully automated. Metabolites of melatonin were identified off-line by LC/MSn experiments. Two metabolites were identified as 6-hydroxymelatonin and cyclic 2-hydroxymelatonin, consistent with ones found previously in the literature.

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          Journal
          10209876
          10.1002/(SICI)1097-0231(19990315)13:5<407::AID-RCM500>3.0.CO;2-I

          Chemistry
          Animals,Biotransformation,Calibration,Chromatography, Liquid,Injections, Intraperitoneal,Male,Mass Spectrometry,Melatonin,analogs & derivatives,analysis,pharmacokinetics,Microdialysis,Rats,Rats, Sprague-Dawley

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